| Computer # |
| 2935.
 | 17 | Microstructure-Informed Susceptibility Source Separation (MI-SSS) for Improved Estimation of Neural Myelin and Iron Content Mert Şişman1,2, Thanh D. Nguyen2, Ilhami Kovanlikaya2, Alexey V. Dimov2, Hannah Schwartz3, Pascal Spincemaille2, Susan A. Gauthier3, and Yi Wang2,4
1Electrical and Computer Engineering, Cornell University, Ithaca, NY, United States, 2Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 3Department of Neurology, Weill Cornell Medicine, New York, NY, United States, 4Biomedical Engineering, Cornell University, Ithaca, NY, United States Keywords: Multiple Sclerosis, Susceptibility Motivation: Current approaches to identify diamagnetic and paramagnetic susceptibility sources in the brain suffer from confounding effects caused by microstructure or pathological changes such as edema. Goal(s): The aim of this study is to present the microstructure-informed framework developed for the improved estimation of diamagnetic and paramagnetic sources free from confounding effects of fiber orientations and edema. Approach: We employ the biophysical modeling-based generation of gradient-echo signals and stochastic matching pursuit for the parameter estimation via a pre-computed dictionary. Results: The results show that MI-SSS is robust against the fiber orientation dependent field effects and increased tissue water. Impact: This study introduces MI-SSS as an improved susceptibility source
separation technique. The aim is to map diamagnetic and paramagnetic source
distributions inside the brain free from the confounding effects of fiber
orientation and water content changes such as in edema. |
| 2936.
 | 18 | Towards precise quantification of chronic active MS lesions using submillimeter isotropic QSM with 3D-EPI at 3T Sreekanth Madhusoodhanan Nair1, Arzu Has Silemek1,2, Brian Renner1, Elaina Gombos1, Bryan Quah1, Mustafa Subhi1, Jin Jin3, Fei Han4, Nader Binesh5, Marcel Maya5, Debiao Li2, Marwa Kaisey1, Nancy L Sicotte1, Omar Al-Louzi1, and Pascal Sati1,2
1Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3Siemens Healthcare Pty Ltd, Brisbane, Australia, 4Siemens Medical Solutions, Los Angeles, CA, United States, 5Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, United States Keywords: Multiple Sclerosis, Multiple Sclerosis Motivation: Quantitative susceptibility mapping (QSM) enables in vivo detection of chronic active brain lesions in Multiple Sclerosis (MS) due the presence of iron-laden lesion borders also called Paramagnetic Rim Lesions (PRL). Goal(s): To evaluate the feasibility of generating submillimeter isotropic resolution QSM using 3D-EPI for precise quantification of PRL in MS patients. Approach: Separate masks for the lesion rim and lesion core were generated. Results: Submillimeter resolution reduces the partial volume averaging effect and enables measurement of the lesion rim in PRL+ lesions, which exhibit susceptibility values 3 times that of the lesion core. Impact: This study demonstrates the feasibility of submillimeter isotropic quantitative susceptibility mapping to precisely quantify the magnetic susceptibility properties of MS lesions. |
| 2937.
 | 19 | Quantitative T2* Ferumoxytol MRI to Evaluate Activated Innate Immunity in Progressive Multiple Sclerosis Seong-Eun Kim1, Trieste Francis2, Ka-Ho Wong2, and M Mateo Paz Soldan2
1UCAIR, Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 2Department of Neurology, University of Utah, Salt Lake City, UT, United States Keywords: Multiple Sclerosis, Contrast Agent, USPIO Motivation: Multiple sclerosis (MS) progression involves inflammation, microglia, and macrophage activation, contributing to axonal damage. Goal(s): This study investigates the utility of ferumoxytol-enhanced MRI for evaluating activated microglia and macrophages in progressive MS.
Approach: . Nine secondary progressive MS patients underwent baseline and post-ferumoxytol 3T MRI scans, with T2* and ΔT2* maps computed to quantify ferumoxytol retention in lesions.
Results: We successfully quantified ferumoxytol levels in ΔT2*-enhanced MS lesions in four subjects. In relapsing MS, newly formed active lesions typically contain a substantial number of macrophages, while chronic-active lesions in progressive MS predominantly exhibit microglia and macrophages in the perilesional area Impact: These findings suggest ferumoxytol-enhanced MRI's potential for assessing microglia and macrophage activity in progressive MS, aiding accurate diagnoses and treatment. Clinicians could gain a valuable tool for monitoring disease progression, improving patient management and outcomes. |
| 2938.
 | 20 | Strategized Replication: Exploring Inconsistencies in QSM-Based Studies of Brain Iron in Multiple Sclerosis Fahad Salman1, Niels Bergsland1, Michael G. Dwyer1,2, Bianca Weinstock-Guttman3, Robert Zivadinov1,2, and Ferdinand Schweser1,2
1Buffalo Neuroimaging Analysis Center, Department of Neurology at the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 2Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States, 3Jacobs Multiple Sclerosis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States Keywords: Multiple Sclerosis, Quantitative Susceptibility mapping, Multiple sclerosis, QSM, thalamus, group differences, susceptibility, patients Motivation: Contradicting evidence exists on thalamic iron alterations in multiple sclerosis, with most studies using susceptibility measurements reporting lower (susceptibility) iron but one study reporting higher. Goal(s): To investigate if the study reporting higher thalamic susceptibility can be reproduced. Approach: We matched demographics and clinical characteristics to the original study (higher susceptibility) and employed six QSM pipelines (two background field removal and three inversion algorithms). Results: Using the original study's pipeline, thalamic and putamen susceptibility was 8ppb (p=0.046) and 1ppb higher in patients, respectively. GP (-7 ppb) and caudate (-1 ppb) showed lower susceptibilities. Consistent group-differences with varying p-values were observed with each pipeline. Impact: This study was able to attribute inconsistencies in observed thalamic (susceptibility) iron alterations to the clinical and demographic characteristics of the studied cohort and provided support for the notion that study outcomes are comparable between different QSM pipelines. |
| 2939.
 | 21 | Subdivisional Iron Deposition and “Swallow Tail Sign” of Substantia Nigra in RRMS Patients by Quantitative Susceptibility Mapping Chun Zeng1
1The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Keywords: Multiple Sclerosis, Multiple Sclerosis, Disease Duration; Substantia nigra; Iron; Swallow tail sign; Quantitative susceptibility mapping Motivation: Regionally progressive iron deposition has not been indicated in the substantia nigra (SN), which is the main impaired region in relapsing-remitting multiple sclerosis (RRMS). Goal(s): To study the iron accumulation in substantia nigra (SN) subdivisions and “swallow tail sign” in RRMS patients with different DDs. Approach: Quantitative susceptibility mapping (QSM) values were measured in the anterior and posterior SN at different levels. Results: QSM values of the SN were higher in RRMS patients with 5-10 years DDs than controls. There were significantly positive correlations between “swallow tail sign” scores and QSM values of the caudal pSN in the patients with long DDs. Impact: This is a preliminary study providing objective evidence of the iron-related progression of SN subregions in RRMS patients with different DDs, and abnormal “swallow tail sign” may provide an additional imaging maker for MS patients. |
| 2940.
 | 22 | To evaluate the degree of brain tissue damage in relapsing-remitting multiple sclerosis patients by using susceptibility weighted imaging Qi Wang1, Ying Shi1, Jianxiu Lian2, and Pengfei Liu1
1The First Affiliated Hospital of Harbin Medical University, Harbin, China, 2Philips Healthcare, Beijing, China Keywords: Multiple Sclerosis, Nerves Motivation: Multiple sclerosis (MS) is a leading cause of disability among young individuals. There is growing evidence showing that vascular and blood flow abnormalities may serve as potential sources of MS lesions. Goal(s): Our goal was to establish the correlation between the deep medullary veins (DMVs) and the clinical indicators of brain tissue damage in MS. Approach: Patients were imaged utilizing susceptibility weighted imaging (SWI) to assess the visibility and morphological changes of DMVs. Results: Damage of DMVs had the significant value in reflecting the degree of brain tissue damage in MS. Impact: Our demonstration of
detectable damage in DMVs utilizing SWI provides a radiological marker for benefiting MS patients in need of assessment. |
| 2941.
 | 23 | Quantitative Myelin Assessment for Multiple Sclerosis Using Multi-Inversion Magnetic Resonance Fingerprinting Yingying Lin1, Koon Ho Chan1, Ka Fung Henry Mak1, Krystal Xiwing Yau1, and Peng Cao1
1The University of Hong Kong, Hong Kong, Hong Kong Keywords: Multiple Sclerosis, MR Fingerprinting, Multiple sclerosis; Myelin water Motivation: Myelin water imaging is a potential tool for observing demyelination in multiple sclerosis (MS).
Goal(s): Using a rapid multiple inversion recovery (mIR) magnetic resonance fingerprinting (MRF) with multiple compartment analysis identified white matter (WM) lesions and evaluated the severity of demyelination by calculating the MWF in WM. Approach: This is a prospective study. Myelin water fraction (MWF) from mIR-MRF of WM in healthy control (HC), normal appear WM in MS patient, and WM lesion in MS patient were calculated. Results: The sensitivity of MWF map on identifying WM lesions was 100%. MWF was statistical difference between MS patient and HC. Impact: The myelin water fraction map achieved from mIR MRF was comparable to FLAIR and MPRAGE in identifying white matter lesions with 100% sensitivity and provided additional insights into the demyelination process of MS. |
| 2942.
 | 24 | Characterization of White Matter Lesions in Multiple Sclerosis using Proton density and T1-relaxation Measures Sagar Buch1, Karthikeyan Subramanian2, Teresa Chen3, Yongsheng Chen4, Mykol Larvie2, Evanthia Bernitsas1, and Ewart Mark Haacke2,4
1Neurology, Wayne State University, DETROIT, MI, United States, 2Radiology, Wayne State University, DETROIT, MI, United States, 3College of Engineering, University of Michigan, Ann Arbor, MI, United States, 4Neurology, Wayne State University, Detroit, MI, United States Keywords: Multiple Sclerosis, Multiple Sclerosis Motivation: There is a limited understanding of the lesion heterogeneity in multiple sclerosis (MS), which needs to be investigated through different imaging techniques. Goal(s): To characterize MS lesions using proton density (PD) and T1-relaxation maps. Approach: PD and T1 data were generated for 20 relapsing-remitting MS patients. Lesions were voxel-wise divided into high PD regions and the remaining lesional tissue. Clinical scores were correlated with total lesion volume, volumes of high PD regions and high T1 regions. Results: Lesions with high PD exhibited highest probability of occurrence at the boundary of lateral ventricles and likely represent chronic lesions with significant local tissue rarefaction. Impact: Proton density and T1-relaxation
maps act as an essential complement to the conventional clinical sequences and
could serve as a new biomarker for assessing tissue damage in white matter
lesions in relapsing-remitting multiple sclerosis patients. |
| 2943.
 | 25 | Cross-Sectional and Longitudinal Evaluation of White Matter Microstructure Damages by Automated Fiber Quantification in Multiple Sclerosis Yongmei Li1 and Zichun Yan1
1Department of Radiology,, the First Affiliated Hospital of Chognqing Medical University, Chongqing, China Keywords: Multiple Sclerosis, Multiple Sclerosis Motivation: Multiple sclerosis (MS) is characterized by a series of pathological processes mainly caused by white matter (WM) lesions. Thus, the correct and comprehensive understanding of WM in RRMS patients is essential for clinical practice. Goal(s): To characterize the WM fiber tracts by automated fiber quantification (AFQ) cross-sectionally and longitudinally, and explore the correlation between the cognitive performance. Approach: The DTI metrics ectracted by AFQ were investigated cross-sectionally and longitudinal in entire and pointwise manners. The partial correlation analyses were performed between the abnormal metrics and the cognitive performance. Results: MS patients showed a widespread WM microstructure alteration, and widely correlated with cognitive performance. Impact: RRMS patients showed a widespread WM microstructure alteration, and the altered metrics were widely correlated with cognitive performance, which will enhance our understanding of WM microstructure damages in RRMS patients. |
| 2944.
 | 26 | Serum 24-Hydroxycholesterol is weakly correlated with brain water content, myelin water fraction and T1 relaxation in different stages of MS Noah Marini1,2, Pierre Becquart3, Roger A Dyer4, Anthony Traboulsee5,6, Robert L Carruthers5, Shannon H Kolind1,2,5,6,7, Alice J Schabas5, Ana-Luiza Sayao5, Virginia Devonshire5, Roger Tam1,8, Wayne Moore2,3,5, David KB Li1,5,6, Jacqueline A Quandt2,3,5, Irene M Vavasour1,2, and Cornelia Laule1,2,3,5
1Radiology, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 3Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 4Analytical Core for Metabolomics and Nutrition, BC Children's Hospital Research Institute, Vancouver, BC, Canada, 5Medicine, University of British Columbia, Vancouver, BC, Canada, 6MSMRI Research Group, University of British Columbia, Vancouver, BC, Canada, 7Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 8School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada Keywords: Multiple Sclerosis, Multiple Sclerosis, serum, white matter, myelin, water content, T1, brain Motivation: Quantitative and specific MRI methods may better characterize brain changes in multiple sclerosis (MS). Serum biomarkers that reflect advanced MRI measures would be an accessible and cost-effective tool for tracking these changes. Goal(s): To explore the ability of serum 24-hydroxycholesterol to reflect changes in advanced brain MRI measures in MS. Approach: 103 MS participants with diverse disease course subtypes underwent 3T MRI and same-day venous blood sampling. Results: Lesion water content and myelin water fraction (MWF), normal appearing white matter MWF and T1, and diffusely abnormal white matter MWF demonstrated relationships with serum 24-hydroxycholesterol in specific disease courses of MS. Impact: Correlation between serum 24-hydroxycholesterol and advanced MRI measures in different MS subtypes encourage further investigation of its use as a supportive marker. The development of MRI and serum markers could improve the sensitivity and frequency of monitoring MS disease progression. |
| 2945.
 | 27 | Increased Cerebral Lactate-to-Pyruvate Ratio in Primary Progressive Multiple Sclerosis using Hyperpolarized Pyruvate MRI. Jordan J. McGing1, Marco Pisa2, Andrew Lockhart2, Kylie Yeung 1,3,4, Aaron Axford1, Rebecca Mills1, Ayaka Shinozaki1,5, Andrew Lewis1, Sarah Birkhoelzer1, Lise Berner3, Fulvio Zaccagna6, Rolf Schulte7, Oliver Rider1, Gabrielle De Luca2, Damian J. Tyler1,5, and James T. Grist1,3
1Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 2Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 3Department of Radiology, Oxford University Hospitals, Oxford, United Kingdom, 4Department of Oncology, Oxford University Hospitals, Oxford, United Kingdom, 5Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 6Department of Radiology, Cambridge University Hospitals, Cambridge, United Kingdom, 7GE Healthcare, Munich, Germany Keywords: Multiple Sclerosis, Multiple Sclerosis, Hyperpolarized MR (Non-Gas) Motivation: There remains an absence of imaging modalities capable of probing the neuroinflammatory processes that precede the well-defined brain structural changes in Primary Progressive Multiple Sclerosis (PPMS). Goal(s): We investigated whether hyperpolarized [1-13C]pyruvate MRI can delineate alterations in cerebral glycolytic and oxidative metabolism between treatment naïve PPMS and healthy volunteers. Approach: Two treatment naïve PPMS patients and two sex matched healthy volunteers underwent [1-13C]pyruvate MRI to characterise cerebral glycolytic and oxidative metabolism. Results: A global increase in [1-13C]lactate: [1-13C]pyruvate was found in both PPMS patients relative to sex-matched healthy controls (0.23 ± 0.12 vs 0.16 ± 0.08). The 13C bicarbonate:[1-13C]pyruvate ratio was no different. Impact: These preliminary findings demonstrate
a global increase in cerebral glycolytic
metabolism in treatment naïve PPMS relative to age and gender matched
healthy controls. This may reflect diffuse neuroinflammatory processes and
suggests [1-13C]pyruvate MRI could be used to monitor disease
activity. |
| 2946.
 | 28 | Resolution of glial activation in relapsing and primary progressive MS over 2 years with ocrelizumab: longitudinal MR spectroscopy study Bretta Russell-Schulz1, Erin L MacMillan2,3, Glaynel Alejo2, Irene M Vavasour2, Christopher Harp4, Briana Cameron4, Ryan Winger4, Sherman Jia4, Ann Herman4, Helen Cross5, Roger Tam1,6, Anthony L Traboulsee1,5, Robert Carruthers5, and Shannon H Kolind1,2,5,7
1MS MRI Research, University of British Columbia, Vancouver, BC, Canada, 2UBC MRI Research, University of British Columbia, Vancouver, BC, Canada, 3Philips Canada, Mississauga, ON, Canada, 4Genentech Inc., A Member of the Roche Group, South San Francisco, CA, United States, 5Medicine, University of British Columbia, Vancouver, BC, Canada, 6School for Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, 7Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada Keywords: Multiple Sclerosis, Spectroscopy Motivation: Need for treatment tracking biomarkers in multiple sclerosis (MS). Goal(s): To demonstrate increased sensitivity to metabolite changes in a more homogeneous MRS voxel in RMS and to investigate whether PMS exhibits a similar trend with treatment. Approach: Single voxel spectroscopy to examine metabolite changes in a large white matter region over time in ocrelizumab treated MS patients compared to single timepoint healthy controls. Results: Marker of glial cell density and activation decreased over 2 years of treatment in both relapsing (similar to previously study) and progressive MS. A weak correlation was observed between the glial marker and measure of disability at baseline. Impact: Magnetic
resonance spectroscopy (MRS) offers biomarkers of glial density/activation that
may solve a clinical unmet need to track the neuroinflammatory response to multiple
sclerosis (MS) therapies. This study demonstrates how MRS biomarkers change with
treatment in MS white matter. |
| 2947.
 | 29 | GABA and Glx levels in relapsing-remitting multiple sclerosis correlate with clinical disability Ying Shi1, Qi Wang1, Jianxiu Lian2, Liangjie Lin2, and Pengfei Liu1
1Departments of Magnetic Resonance, The First Affiliated Hospital of Harbin Medical University, Harbin, China, 2Philips Healthcare, Beijing, China Keywords: Multiple Sclerosis, Multiple Sclerosis, Relapsing-remitting multiple sclerosis; Gamma- aminobutyric acid; Glutamine–glutamate complex; Magnetic resonance spectroscopy Motivation: Multiple sclerosis (MS) is a leading cause for clinical disability in youth and middle-aged people. Goal(s): Multiple researches have implicated glutamine–glutamate complex (Glx) and gamma- aminobutyric acid (GABA) as key roles in neuronal signalling and other central functions. In MS patients, dysfunctional Glx excitation and/or GABA inhibition may contribute to neurological symptoms and disease progression. Approach: To identify the relationship between metabolic abnormalities and clinical disability, the metabolism of brain tissue was investigated by using MEscher-GArwood Point RESolved Spectroscopy. Results: Decreasing levels of GABA+/tCr and increasing levels of Glx/tCr were found in the precentral gyrus and postcentral gyrus VOIs of MS patients. Impact: GABA and Glx detected by MEGA-PRESS MRS were utilized for investigating correlations between metabolic abnormalities in brain tissue and clinical disability. |
| 2948.
 | 30 | Imaging the brain with multiple sclerosis using 3D CUBE CEST MRI at clinical 3T Jianpan Huang1, Yingying Lin1, Peng Cao1, Chia-Wei Lee2, Ziyan Wang1, Pei Cai1, Chi Yan Lee3, Kyongtae Ty Bae1, Henry KF Mak1, Kannie WY Chan4,5,6, and Koon Ho Chan3
1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China, 2Research Group, GE Healthcare, Taipei, Taiwan, 3Department of Medicine, The University of Hong Kong, Hong Kong, China, 4Department of Biomedical Engineering, The University of Hong Kong, Hong Kong, China, 5Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong, China Keywords: Multiple Sclerosis, Multiple Sclerosis Motivation: CEST MRI is a molecular imaging technique that has potential to image the changes of lipids and proteins during demyelination in human brain with multiple sclerosis (MS). Goal(s): We aimed to explored the sensitivity of different CEST contrasts in differentiating MS brain from healthy control (HC) brain at 3T. Approach: CEST MRI based on a 3D CUBE acquisition module was applied to image the brain of MS patients and HC subjects at a clinical 3T scanner. Results: CEST MRI could sensitively identify MS from HC. Amide CEST, rNOE and MT showed significantly lower signals in the MS brain compared to HC brain. Impact: This study demonstrated the alterations in CEST contrasts in the human brain with multiple sclerosis using a clinical 3T MRI. It provides valuable insights for the clinical application of CEST MRI in diagnosing multiple sclerosis. |
| 2949.
 | 31 | Study of Neurometabolic Alterations in Multiple Sclerosis Using Fast High-Resolution 3D 1H-MRSI Bin Bo1, Tianyang Sheng2, Weijun Tang3, Yibo Zhao4,5, Yudu Li4,6, Wen Jin4,5, Rong Guo4,7, Xiangjun Chen2, Zhi-Pei Liang4,5, and Yao Li1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China, 3Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China, 4Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 6National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 7Siemens Medical Solutions USA, Inc., Urbana, IL, United States Keywords: Multiple Sclerosis, Multiple Sclerosis Motivation: Multiple sclerosis (MS) is characterized by diverse metabolic alterations. 1H-MRSI provides a unique capability for non-invasive mapping of neurometabolites but is often limited in resolution, scanning time, and brain coverage. Goal(s): Our goal was to demonstrate the feasibility of high-resolution whole-brain 1H-MRSI for characterizing metabolic alterations in MS. Approach: 3D 1H-MRSI scanning using SPICE technology (scan time: 10 minutes, resolution: 2×3×3 mm3, FOV: 240×240×120 mm3) was performed on 44 MS patients. Results: N-acetylaspartate (NAA), myo-inositol (mI), creatine, and choline levels altered among different lesion types and peri-plaque regions. NAA and mI/NAA differentiated RRMS and PMS patients in association with clinical scores. Impact: High-resolution whole-brain 1H-MRSI
provides a promising tool for non-invasive metabolic imaging to characterize MS
pathophysiology. |
| 2950.
 | 32 | Assessment of region-specific oxidative stress in multiple sclerosis using short-TE STEAM at 7T Sneha Senthil1, Jamie Near2, Flavie Detcheverry3, Vladimir Fonov1, Rozie Arnaoutelis1, Douglas L. Arnold1, AmanPreet Badhwar3, and Sridar Narayanan1
1Montreal Neurological Institute-Hospital, McGill University, Montreal, QC, Canada, 2Medical Biophysics, Sunnybrook Research Institute, Toronto, ON, Canada, 3Centre de recherche de l'Institut universitaire de gériatrie de Montréal, Université de Montréal, Montreal, QC, Canada Keywords: Multiple Sclerosis, Multiple Sclerosis, MR spectroscopy, Oxidative Stress, Glutathione Motivation: Brain oxidative stress has an important role in the pathophysiology of multiple sclerosis (MS). Goal(s): This work assessed oxidative stress in relapsing remitting MS (RRMS) by measuring the major brain antioxidant, glutathione (GSH). Approach: GSH concentrations were measured using 7T MRS in the posterior cingulate cortex (PCC) and centrum semiovale white matter (CSWM) of 10 RRMS patients and 13 matched healthy controls. The relationship between GSH concentrations and functional measures was also investigated. Results: This preliminary investigation showed no significant difference in GSH concentration between RRMS and healthy participants, and no significant relationship between GSH concentration and functional measures. Impact: Oxidative stress was not detected in our RRMS participants, concordant with one previous study. Prior work has shown low GSH in progressive MS. Further work with larger sample sizes will investigate oxidative stress in RRMS participants at risk of progression. |