| Computer # |
| 4295.
 | 129 | Efficacy for asymmetric Fast 3D wheel technique on female pelvic MRI on contrast enhanced 3D T1-weighted image Takahiro Ueda1, Yoshiharu Ohno2, Kaori Yamamoto3, Natsuka Yazawa3, Ikki Tozawa4, Masato Ikedo3, Masao Yui3, Hiroyuki Nagata5, Masahiko Nomura1, and Yoshiyuki Ozawa1
1Radiology, Fujita Health University School of Medicine, Toyoake, Japan, 2Diagnostic Radiology, Fujita Health University School of Medicine, Toyoake, Japan, 3Canon Medical Systems Corporation, Otawara, Japan, 4Radiology, Fujita Health University Bantane Hospital, Nagoya, Japan, 5Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University School of Medicine, Toyoake, Japan Keywords: Pelvis, Pelvis Motivation: Fast 3D Wheel with Sequential filling and Asymmetric Fourier imaging (Fast 3Dwsa) which is one of the k-space based acceleration techniques can improve image quality and acquisition time. Goal(s): The goal was to determine the utility of contrast-enhanced 3D T1-weighted image with Fast 3Dwsa on female pelvic MRI as compared with conventional parallel imaging (PI) and compressed sensing (CS). Approach: Quantitative and qualitative indexes for image quality improvement and reducing acquisition time were statistically compared among all methods. Results: Quantitative and qualitative indexes of Fast 3Dwsa was significantly better than that of PI and CS (<0.05). Impact: Fast 3Dwsa is considered as useful for image quality improvement with reducing acquisition time on female pelvic MRI, when compared with conventional PI as well as CS. |
| 4296.
 | 130 | Usages of Half Fourier single shot turbo spin echo with deep learning reconstruction and variable flip angle in gynecology Mitsuhiro Kirita1, Yuki Himoto1, Aki Kido2, Yasuhisa Kurata1, Hiroyasu Abe3, Koji Fujimoto4, Yuka Matsumoto1, Kumi Harada1, Satoshi Morita5, Masaki Mandai6, and Yuji Nakamoto1
1Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, kyoto, Japan, 2Department of Radiology, Toyama University, Toyama, Japan, 3School of Pharmaceutical Sciences, Wakayama Medical University, Wakayama, Japan, 4Real World Data Research and Development, Kyoto University Graduate School of Medicine, kyoto, Japan, 5Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, kyoto, Japan, 6Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, kyoto, Japan Keywords: Pelvis, Uterus Motivation: Without antispasmodics, obtaining T2-weighted images with robustness to artifacts and high tissue contrast is challenging in gynecologic MRI. Goal(s): Our goals were to investigate HASTE with deep learning-reconstruction and a variable flip angle technique (iHASTE) outperforming conventional sequences without antispasmodics, and to explore its clinical usages. Approach: The comparison between iHASTE, HASTE, and BLADE without antispasmodics, and the comparison between iHASTE without antispasmodics and TSE with antispasmodics, were performed. Results: Without antispasmodics, iHASTE outperformed HASTE and BLADE. Compared with TSE with antispasmodics, iHASTE was superior in the robustness to artifact, although inferior in overall imaging quality. Impact: In gynecologic MRI, HASTE with deep learning-reconstruction and a variable flip angle technique could be clinically the first choice when antispasmodics are unavailable. Even with antispasmodics, it could back up deteriorated TSE via artifacts, for its robustness and rapidity. |
| 4297.
 | 131 | The Influence of Pelvic Configuration on Pelvic Organ Prolapse in Females of All Ages Luyang Ma1, Yujiao Zhao2, Xiaodong Ji2, Lixiang Huang2, Cheng Zhang1, and Wen Shen2
1The First Central Clinical School, Tianjin Medical University, Nankai District, Tianjin, China, 2Department of Radiology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China Keywords: Pelvis, Prevention, MR imaging;pelvimetry Motivation: Pelvic organ prolapse(POP) is a common disease in women, and pelvic geometry is one of the influencing factors. Goal(s): To compare pelvic dimensions in women between diagnosed with POP and control group encompassing all age groups. Approach: 130 patients with POP and equal women without any pelvic floor dysfunction were retrospectively enrolled.After excluding collinearity, pelvic measurement parameters were included in univariate and multivariate logistic regression to screen independent risk factors, and finally demographic parameters were included to verify their independence. Results: Pelvic geometry has a role in the incidence of POP, and that having a large pelvis increases the risk of POP. Impact: A large pelvis is one of the risk factors for POP, which are expected
to play a warning role in early prevention in clinical work and are not
affected by clinical factors. |
| 4298. | 132 | Investigating the Feasibility of Upright 0.5T MR Defaecating Proctography: initial results reveal potential for clinical assessments. Rashed Sobhan1, Paul Glover1, Penny Gowland1, Rahul Munyal 2, Olivier Mougin1, and Christopher Clarke2
1Sir Peter Mansfield Imaging Center, University of Nottingham, Nottingham, United Kingdom, 2Department of Radiology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom Keywords: Pelvis, Low-Field MRI, Proctography, Pelvic floor disorder Motivation: Pelvic floor assessments using X-ray proctography involve ionising radiation and only image the posterior compartment. Conventional supine-MR defaecography lacks in sensitivity as it fails to replicate the physiological position of defaecation. Upright-MR avoids ionising radiation and allows defaecography in sitting position whilst visualising all pelvic compartments. Goal(s): To image defaecation using upright scanner with optimised acquisition and assess its feasibility for clinical defaecography. Approach: Upright scanner with purpose-built commode coil and optimised HASTE acquisition were used to capture pelvic floor changes during defaecation in sitting position. Results: Structural and functional images were satisfactory for qualitative and quantitative clinical assessments−performed by two experienced Radiologists. Impact: Our upright 0.5T scanner with purpose-built RF commode coil and
optimised HASTE acquisition will enable Radiologists to identify anatomical and
functional abnormalities in pelvic floor disorders. The technique shows
potential to be a compatible alternative to X-ray Proctography. |
| 4299.
 | 133 | Does Amide proton transfer-weighted mri have diagnostic and differential value in ovarian cystic and predominantly cystic lesion ？ Fang Wang1, Dawei Ding1, Lingyu Chang1, Dmytro Pylypenko2, Weiqiang Dou2, Dexin Yu1, and Qing Wang1
1Qilu Hospital of Shandong University, Jinan city, Shandong province, China, 2GE Healthcare, Beijing, China, Beijing, China Keywords: Pelvis, CEST & MT, APTw Motivation: Ovarian cystic and predominantly cystic lesions are common tumor-like formations within the ovaries, necessitating precise diagnosis and differential analysis for effective clinical management. Goal(s): This study examines the effectiveness of amide proton transfer-weighted (APTw) MRI in differentiating cystic or predominately cystic ovarian lesions.
Approach: 49 patients with ovarian lesions were prospectively scanned by APTw before surgery, and 20 volunteers were also scanned by APTw as a control group. Results: The results demonstrate APTw MRI's substantial value in identifying and distinguishing common ovarian cystic and predominantly cystic lesions, offering enhanced diagnostic precision in ovarian pathology. Impact: MR diagnostic techniques for ovarian lesions, including DWI and DCE-MRI, have their limitations. A timely diagnosis is crucial for improving patient prognosis. APTw imaging has shown research progress across various systems, yet its application in ovarian studies remains limited. |
| 4300.
 | 134 | Characterising placental contractions Penny Gowland1, Amy Turnbull1, George Hutchinson1, Louise Dewick2, Ruizhe Li3, Chris Bradley1,4, Xin Chen3, Grazziela Figueredo3, Simon Stockwell5, Divya Ramesh1, Neele Dellschaft1, Kate Walker2, and Nia Jones2
1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2School of Medicine, University of Nottingham, Nottingham, United Kingdom, 3School of Computer Science, University of Nottingham, Nottingham, United Kingdom, 4National Institute for Health Research, Biomedical Research Centre, Hospital NHS Trust and University of Nottingham, Nottingham, United Kingdom, 5Faculty of Engineering, University of Nottingham, Nottingham, United Kingdom Keywords: Placenta, Placenta Motivation: We have previously observed placental contractions and now want to charcterise them further. Goal(s): To characterise placental contractions (frequency, amplitude and length) in normal pregnancy. Approach: Dynamic respiratory gated multislice EPI scans acquired for 30 minutes across the pregnant uterus, analyzed by automatic segmentation. Results: Placental contractions lasting several minutes and sometimes causing very large changes in placental volume, were found in every woman studied. Impact: Further work will investigate the function of contractions
and whether they are altered in compromised pregnancies. |
| 4301.
 | 135 | Late-term Prenatal MRI for Evaluating Maternal Changes and their Correlation with Supine Hypotension Syndrome for Cesarean Section Rui Ma1, TaoTao Sun2, and Feifei Qu3
1Department of Anesthesiology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, ShangHai, China, 2Department of Radiology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, ShangHai, China, 3Siemens Healthineers, MR Research Collaboration, ShangHai, China Keywords: Uterus, Prenatal, Supine hypotension syndrome, Gynecology Motivation: Effectively preventing supine hypotension syndrome (SHS) is difficult due to the lack of sufficient in vivo abdominal MRI data. Goal(s): This study aimed to retrospectively analyze the changes in the quantitative parameters of maternal MRI in late pregnancy to identify potential predictors of SHS. Approach: By examining late-term prenatal MRI scans, we observed changes in several quantitative parameters. Results: The abdominal–right uterine surface area ratio, dural sac anteroposterior diameter, ratio of epidural space anteroposterior diameter to dural sac, anteroposterior diameter, and left and right vertebral vein short-axis measurements were found to be helpful in determining SHS. Impact: Late-term prenatal MRI can fully display the changes in maternal structure, providing a method for preoperative prediction of SHS after anesthesia. |
| 4302.
 | 136 | Ex-vivo MRI of Placentas from Women with Congenital Heart Disease: Reproducibility Assessment and Initial Results Ana Rodríguez-Soto1, Daphna Link-Sourani2, Dafna Ben-Bashat3,4, Rebecca Rakow-Penner1, Mana Parast5,6, and Francisco Contijoch1,7,8
1Radiology, University of California San Diego, La Jolla, CA, United States, 2Biomedical Engineering, Technion- Israel Institute of Technology, Haifa, Israel, 3Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, 4Sagol Brain Institute, Tel Aviv Sourasky Medical Cente, Tel Aviv, Israel, 5Department of Pathology, University of California San Diego, La Jolla, CA, United States, 6Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, United States, 7Bioengineering, University of California San Diego, La Jolla, CA, United States, 8Rady Children’s Hospital, San Diego, CA, United States Keywords: Placenta, Cardiovascular Motivation:
Women with CHD are prone to pregnancy complications associated with placental-dysfunction. Our understanding of this phenomenon remains limited, with unexplored data processing reproducibility. Goal(s):
1. Investigate maternal cardiovascular health's impact on placental vascular architecture.
2. Evaluate data processing method reproducibility. Approach:
Placentas from mothers with cardiovascular disease and controls underwent ex-vivo MRI. Placental volume and vascular tree architecture were analyzed by two independent double-blinded annotators using established methods. Results:
No group differences were observed. Annotator-related differences were only observed for vascular volume. We emphasize the need for expanded research into placental changes in women with cardiovascular diseases and standardization of data processing methods. Impact:
This study investigates maternal cardiovascular health's impact on placental vascular architecture and evaluates data processing methods reproducibility. In order to understand placental dysfunction patterns across different populations, the need for expanded research and method standardization became evident. |
| 4303.
 | 137 | Assessing Automated Vessel Segmentation Techniques of Feto-Placental Vasculature from MRI Joanna Chappell1, Magdalena Sokolska2, Rosalind Aughwane3, Alys R Clark4, Sebastien Ourselin 1, Anna L David3,5, and Andrew Melbourne1
1School of Biomedical Engineering and Imaging Sciences (BMEIS), Kings College London, London, United Kingdom, 2Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 3Elizabeth Garrett Anderson Institute for Women’s Health, University College London, London, United Kingdom, 4Auckland Bioengineering Institute, Auckland, New Zealand, 5University College London Hospital NHS Foundation Trust, London, United Kingdom Keywords: Placenta, Placenta Motivation: Placental insufficiency is a factor that contributes to multiple pregnancy complications such as Fetal Growth Restriction (FGR). Goal(s): Providing better understanding to clinicians is important for future treatment planning and automatic detection of the feto-placental vasculature from imaging may provide a tool to guide clinical assessment. Approach: This work compared the Frangi filter and an edge-based detection algorithm abilities to automatically identify feto-placental vasculature from MRI. Results: The study found that both methods identified likely vascular structures, and both showed spatial trend similarities when compared with gold-standard/high resolution Micro-CT, as well as a showing differences between FGR and Control vessel segmentations. Impact: Evaluating the most accurate method for automatically identifying feto-placental vasculature will go on to further aid quantifying placental insufficiency and improving understanding for predicting and clinically treating conditions such as fetal growth restriction. |
| 4304.
 | 138 | Deep Learning-based Placental MRI Segmentation and Placental Boundary Vessel Recognition Feng Gao1, Le Fu2, Jiejun Cheng2, Jie Shi3, Haima Yang4, and Zhijie Shi4
1Shanghai first maternity and infant hospital, Shanghai, China, Shanghai, China, 2Shanghai first maternity and infant hospital, Shanghai, China, 3MR Research, GE Healthcare, Beijing, China, 4University of Shanghai for Science and Technology, Shanghai, China Keywords: Placenta, Placenta Motivation: Accurate automatic segmentation of the placenta and identification of blood vessel distribution at the placental borders are crucial for diagnosing placental accrete spectrum (PAS) in MRI, yet effective methods are currently limited. Goal(s): Introduce a refinement fusion method based on U-Net (RFU-Net) for accurately segmenting the placenta. And propose a boundary de-precision (BD) technique to identify the blood vessel distribution around the placental boundary. Approach: MRI of 200 pregnant females were enrolled. RFU-Net and BD were conducted and evaluated. Results: RFU-Net improved the accuracy of placenta segmentation (Dice = 0.9314). The BD resolved the blurring of the placenta boundary. Impact: This study provided a novel method for the automatic
identification of placental border vessel distribution. |
| 4305.
 | 139 | Prognosticating Maternal and Neonatal Outcomes in Placenta Accreta Spectrum Disorders by Combining Placental Perfusion and MRI Features Jin Zhang*1, Lingnan Kong*1, Feifei Qu2, Ting Chen1, Xin Zhou3, Zhiping Ge3, Bai Jin3, Xuan Zhang#1, and Meng Zhao#1
1Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2MR Research Collaboration, Siemens Healthineers, Shanghai, China, Shanghai, China, 3Department of Obstetrics & Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Keywords: Placenta, Placenta, Diffusion-weighted imaging, intravoxel incoherent motion, perfusion, placenta accreta spectrum, postpartum hemorrhage, screening Motivation: The factors to predict adverse maternal and neonatal outcomes in patients with placenta accreta spectrum disorders needed identification. Goal(s): This study aimed to identify appropriate predictive indicators using magnetic resonance imaging (MRI) and intravoxel incoherent motion (IVIM) parameters. Approach: The study examined the association between various influencing factors (clinical risk factors, MRI features, and IVIM parameters) and adverse outcomes using univariate and multivariate analyses. Results: Independent predictors of a poor prognosis included previous cesarean sections, low-signal-intensity bands on T2WI, and D value. Impact: The
components of the prediction model in this study were more comprehensive and
improved the prediction efficiency. The study analyzed the relationship between
f value and postpartum hemorrhage and
further examined the importance of IVIM in predicting adverse outcomes. |
| 4306.
 | 140 | Repeatability of Cervix Restriction Spectrum Imaging Outputs in Healthy Cervix Jayden Sawhney1, Summer Joyce Batasin1, Thien Truong1, Sheida Ebrahimi1, Ana Rodriguez-Soto1, and Rebecca Rakow-Penner1,2
1Radiology, University of California, San Diego, San Diego, CA, United States, 2Bioengineering, University of California, San Diego, San Diego, CA, United States Keywords: Pelvis, Pelvis, Cervix RSI Repeatability Motivation: The American College of Radiology advocates the integration of DW-MRI in the assessment and post-treatment monitoring of cervical cancer. Restriction Spectrum Imaging (RSI) is an advanced diffusion model which has the potential to separate active malignancy from post treatment changes. Goal(s): Investigate the repeatability of cervix-specific RSI outputs (C1, C2, C3) in healthy cervix. Approach: Performed ‘test’ and ‘retest’ scans of a multi-shell diffusion sequence on nine subjects. Intraclass correlation coefficients (ICC) were calculated for each C-compartment. Results: C1 showed poor agreement, while C2 and C3 showed high agreement. Impact: Cervix-specific RSI outputs C2 and C3 showed high agreement, making steps towards repeatable DW-MRI associated biomarkers. Ensuring their repeatability is crucial for their practical application in clinical settings. |
| 4307.
 | 141 | Radiomic Features of Placental Magnetic Resonance Imaging Identify Adverse Pregnancy Outcomes: A Pilot Study Quyen N. Do1, Yin Xi1, Matthew A. Lewis1, Baowei Fei2,3, Catherine Y. Spong4,5, Diane M. Twickler1,4,5, and Christina L. Herrera4,5
1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Bioengineering, The University of Texas at Dallas, Richardson, TX, United States, 3Center for Imaging and Surgical Innovation, The University of Texas at Dallas, Richardson, TX, United States, 4Obstetrics & Gynecology, UT Southwestern Medical Center, Dallas, TX, United States, 5Parkland Health, Dallas, TX, United States Keywords: Placenta, MR Value, chronic hypertension, radiomic analysis, preeclampsia, small for gestational age Motivation: Chronic hypertension (cHTN) is a significant obstetric condition with increased risk of adverse outcomes. Radiomic analysis of MR images may be able to predict outcomes before development of clinical findings. Goal(s): Our goal was to compare MR T2W radiomic features among 4 clinical outcomes: normal, cHTN, preeclampsia with severe features, and small for gestational age (SGA). Approach: We applied ROI-based radiomics analysis on prospectively collected T2W MR images in normal and cHTN pregnancies. Results: We found that MR T2W radiomic features as early as 16 weeks can identify those patients who develop preeclampsia with severe features and whose infants are born SGA. Impact: We demonstrated that MR T2W radiomic features as early as 16 weeks can identify those patients who develop preeclampsia with severe features and whose infants are born small for gestational age. |
| 4308.
 | 142 | Vasculature Assessment of Rhesus Macaque Placental Injury using Variable Flip Angle T1-Mapping and Dynamic Contrast Enhanced MRI Ruiming Chen1, Daniel Seiter1, Jessica Vazquez2,3, Logan Keding2,3, Kathleen Antony3, Heather Simmons2, Puja Basu2, Andres Mejia2, Kevin Johnson1,4, Aleksandar Stanic-Kostic3, Ruo-Yu Liu1, Dinesh Shah3, Thaddus Golos2,3,5, and Oliver Wieben1,4
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, United States, 3Obstetrics & Gynecology, University of Wisconsin - Madison, Madison, WI, United States, 4Radiology, University of Wisconsin - Madison, Madison, WI, United States, 5Comparative Biosciences, University of Wisconsin - Madison, Madison, WI, United States Keywords: Placenta, Placenta Motivation: A combination of DCE and fractional blood volume analysis could enable better evaluation of local placental injury. Goal(s): To generate and assess local placental injury for rhesus macaques using Tisseel (fibrin sealant) injections and co-registered contrast arrival time maps and fractional blood volume maps. Approach: Three rhesus macaques received intraplacental injections of Tisseel to potentially cause tissue ischemia. DCE imaging and variable flip angle T1 mapping were registered and compared qualitatively and quantitatively on a local level. Results: Possible local placental ischemia observed in both the DCE signal and the blood volume maps. Lower circulating blood volume corresponded regionally to longer arrival times. Impact: This study successfully creates local placental ischemia that potentially mimics clinical cases seen with fetal growth restriction. The local ischemia could be better visualized using two co-registered MRI methods, thus helping future clinical diagnosis. |
| 4309.
 | 143 | Stratified management of gestational hypertension: Superiority of functional magnetic resonance parameters over ultrasonography Jing Deng1, Yuwei Cao1, Feifei Qu2, Aining Zhang1, Meng Zhao1, Xihu Mu1, Xin Zhou3, Yanglei Wu4, Jiacheng Song1, Feiyun Wu1, and Ting Chen1
1Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2MR Research Collaboration, Siemens Healthineers, Shanghai, China, 3Department of Obstetrics & Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 4MR Research Collaboration, Siemens Healthineers, Beijing, China Keywords: Placenta, fMRI, gestational hypertension, placenta, preeclampsia, virtual magnetic resonance elastography Motivation: Effective prenatal prediction of gestational hypertension (GH) can improve the clinical management of pregnant women at high risk of preeclampsia (PE) as pregnancy progresses. Goal(s): To investigate the findings of placental virtual magnetic resonance elastography (vMRE), intravoxel incoherent motion (IVIM) parameters, and ultrasound examination to predict the progression of GH to PE. Approach: We calculated vMRE and IVIM parameters and apparent diffusion coefficient and retrospectively performed ultrasound examinations. The differences in the aforementioned parameters were compared, and their predictive efficacy was evaluated. Results: Patients with PE had higher placental stiffness and lower microcirculation. Impact: Virtual magnetic resonance elastography and intravoxel incoherent motion comprise a vital complementary diagnostic method to conventional ultrasound screening for placental dysfunction in patients with high-risk hypertensive disorders in pregnancy, further improving the sensitivity and specificity of pregnancy screening. |