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| 2904.
 | 129 | Predictors of 0.55T Respiratory Navigated Lung MRI Degradation Richard Brandon Schonour1, Felicia Tang2, Kiara Bowers2, Pan Su3, Peder Larson4, Michael Ohliger4, Yoo Jin Lee4, Jonathan Liu4, Yang Yang4, and Jae Ho Sohn4
1College of Medicine, University of South Alabama, Mobile, AL, United States, 2School of Medicine, University of California San Francisco, San Francisco, CA, United States, 3Siemens Medical Solutions USA, Inc., Malvern, PA, United States, 4Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States Keywords: Lung, Low-Field MRI Motivation: The image quality generated using respiratory triggered sequences on low-field scanners is sometimes degraded, and it is currently not well known what causes this. This degradation can lead to image misinterpretation.
Goal(s): Our goal was to determine possible predictors of image quality degradation in low-field lung MRI.
Approach: Six radiologists graded anatomic 0.55T MRI images, and then analysis of patient clinical history, demographics, and respiratory navigation was conducted to determine any patterns.
Results: We found that clinical conditions including fibrotic interstitial lung disease and pulmonary artery pathologies, as well as descriptors such as increased body mass index can predict image quality degradation.
Impact: Our observation of degradative predictors serves as the foundation for research into altering of 0.55T MRI parameters to limit the degree of degradation, so that at-risk patients can still be scanned on these low-field machines with optimal image quality. |
| 2905.
 | 130 | Pulmonary function in sarcoidosis: Comparison between matrix pencil decomposition MRI at 0.55T and lung function tests Maurice Pradella1, Hanns-Christian Breit1, Oliver Bieri2,3, Michael Bach1, Jens Bremerich1, Katrin Esther Hostettler4, and Grzegorz Bauman2,3
1Department of Radiology, University Hospital of Basel, Basel, Switzerland, 2Division of Radiological Physics, Department of Radiology, University Hospital of Basel, Basel, Switzerland, 3Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland, 4Clinic of Respiratory Medicine, University Hospital of Basel, Basel, Switzerland Keywords: Lung, Lung, Low-field Motivation: Sarcoidosis is a systemic inflammatory disease in particular affecting lung tissue, thus there is a need for non-invasive and ionizing radiation free technique to assess regional lung function. Goal(s): To examine correlations between functional lung MRI and pulmonary lung function tests in patients with sarcoidosis. Approach: Lung ventilation and perfusion was assessed using matrix pencil decomposition MRI at a low-field 0.55T MR-scanner in sarcoidosis patients and a control group of healthy volunteers. Conventional lung function tests in patients were performed with spirometry and body plethysmography. Results: Strong correlations between the functional lung MRI and the metrics from conventional pulmonary function tests were observed. Impact: To our
knowledge, this is the first study focused on the evaluation of lung
function using MRI in sarcoidosis patients. Our results support the use of MRI
as a non-invasive diagnostic tool to assess lung function in patients with
sarcoidosis. |
| 2906.
 | 131 | Lung MRI Screening protocol at 0.55T: Initial Experience in Healthy Volunteers Yoo Jin Lee1, Jae Ho Sohn1, Dante Capaldi2, Jonathan Liu1, Shrav Shridhar1, and Yang Yang1
1Department of Radiology and Biomedical Imaging, Univeristy of California, San Francisco, San Francisco, CA, United States, 2Department of Radiation Oncology, Univeristy of California, San Francisco, San Francisco, CA, United States Keywords: Lung, Low-Field MRI Motivation: The current clinical standard for screening lung imaging is chest CT, which is associated with radiation exposure and only provides static, anatomical information of the lung and concurrently imaged heart. Goal(s): We are exploring an alternative method for lung pathology screening. Approach: Using a 0.55T MRI scanner and the proposed screening Lung MRI protocol, we conducted lung MRI scans on 10 healthy volunteers. Results: Initial assessments demonstrate concurrent evaluation of the anatomy, motion, and tissue characteristics of the lung and heart in around 25 minutes. Impact: We propose
a screening Lung MRI protocol as a potential alternative imaging option in
screening as well as follow up imaging in particular conditions, with the
benefit of eliminating radiation dose and additional respiratory and cardiac motion
and tissue information |
| 2907.
 | 132 | Quantitative Lung T1 and T2* Mapping with Upright 0.5T MR: investigating the effect of gravity on lung regions under low-field strength Rashed Sobhan1, Olivier Mougin1, and Penny Gowland2
1Sir Peter Mansfield Imaging Center, University of Nottingham, Nottingham, United Kingdom, 2University of Nottingham, Nottingham, United Kingdom Keywords: Lung, Low-Field MRI, Quantitative parametric mapping, Upright MRI, Gravity on Lung Motivation: Quantitative lung parametric mapping can characterise morphometric and functional changes in pulmonary disorders. Higher field lung-MRIs suffer from field inhomogeneity, and supine MRI does not replicate physiology during daily tasks and is not suitable for some lung patients. Goal(s): Use low-field, upright-MR, quantify T1 and T2* of different lung regions and investigate how gravity impacts these parameters while seated. Approach: A 0.5T ASG MROpen scanner was used to acquire breath-hold images using multi-TE GE (T2*) and variable flip angle method (T1); linear regression extracted the relaxation times. Results: Although supine position showed similar T1 and T2*, gravity incurred a cranial-caudal gradient while seated. Impact: Our low-field, upright-MR parametric mapping mitigates the
limitations of higher-field lung-MRI and explores how relaxations change with
gravity. Using the proposed methods, clinicians can characterise pathologies
like COPD as well as get crucial functional information of lungs during diurnal
postures. |
| 2908.
 | 133 | Measurement of in vivo T2* of inhaled perfluoropropane gas and its dependence on lung microstructure. Dominic Harrison1,2, Mary Neal1,2, and Pete Thelwall1,2
1Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom, 2Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom Keywords: Lung, Lung Motivation: The T2* of inhaled perfluoropropane gas is determined by lung microstructure due to its dependence on the magnetic susceptibility of airway and tissue components, granting the potential to report on lung pathophysiology. Goal(s): To implement a robust measurement of the T2* of inhaled perfluoropropane, to lead to early detection of structural alterations from lung pathologies. Approach: We’ve acquired spatially localized 19F-MRS T2* measurements of perfluoropropane in healthy volunteers at different inhalation depths. Results: We observed a 12% variation in T2* between maximum and minimum inhalation, demonstrating T2*’s sensitivity to physiological change, and potential for early detection of microstructural change associated with lung disease. Impact: A spatially localized measurement of perfluoropropane T2* has sensitivity to change in lung microstructure due to physiological change. These data show the potential of 19F-MRI to report on pathology-driven microstructural change, which may allow for early detection of lung disease. |
| 2909.
 | 134 | Exploration of the Jacobian Determinant in Voxel-wise Lung Ventilation (VOLVE) Analysis to Assess Local Expansion in COPD Zachary Peggs1,2, Jonathan Brooke2, Charlotte E Bolton2, Ian Hall2, Susan Francis1, and Penny Gowland1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Biomedical Research Centre (BRC), Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom Keywords: Lung, Quantitative Imaging, Registration Motivation: To develop 1H MRI methods to study dynamical lung expansion as a marker of lung function. Goal(s): To collect free breathing 1H MRI over the respiratory cycle and investigate the feasibility of using the Jacobian determinant of the registered images for dynamic functional assessment of local expansion, instead of the signal intensity as is used in FD/PREFUL analyses. Approach: Voxel-wise lung ventilation (VOLVE) analysis using the timecourse of deformation based Jacobian determinant to assess the ventilation correlation coefficient. Results: Significant differences in the Jacobian-derived correlation coefficient between healthy and COPD groups indicating differences in local expansion which may provide a lung functional marker. Impact: The Jacobian determinant obtained from registering free breathing 1H lung MRI images provides a metric of local expansion related to respiratory phase, which is sensitive to lung disease. This motivates future work to combine signal intensity-based and deformation-based functional assessments. |
| 2910.
 | 135 | Adaptation of lung mechanics during constrained breathing using 3D MRI spirometry Adrien Duwat1, Nathalie Barrau2, Anna Reitmann2, Angéline Nemeth2, Antoine Beurnier3, Tanguy Boucneau4, Claire Pellot-Baraka2, Vincent Lebon2, and Xavier Maître2
1Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Zoteux, France, 2Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Orsay, France, 3Hôpital Bicêtre, APHP, Le Kremlin-Bicêtre, France, 4GE Healthcare, Buc, France Keywords: Lung, Lung, Spirometry, biomarkers, biomechanical Motivation: New mechanical biomarkers to characterize lung pathophysiology using 3D MR spirometry. Goal(s): To investigate the dynamics of lung elongations along the three anatomical directions when the lungs are constrained during breathing. Approach: 3D MR spirometry was performed in 25 healthy volunteers spontaneously breathing and in a healthy volunteer for three types of breathing (spontaneous, thoracic, diaphragmatic). Results: The main respiratory driving force is produced by the diaphragm as it is assessed here with a dominant superior-inferior normal strain in basal pulmonary regions. In spontaneous breathing, it is supplemented mainly by the anterior-posterior normal strain in the apical regions. Impact: Dynamic normal strains are original mechanical biomarkers
that provide new insight on the regional anisotropic behaviour of the lungs. |
| 2911.
 | 136 | Investigating SMS in dynamic MR for Free-Breathing Functional Lung Imaging Efe Ilıcak1,2, Daniel Stäb3,4, Peter Speier5, Ralph Strecker6, and Frank Gerrit Zöllner1,2
1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 2Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 3MR Research Collaborations, Siemens Healthcare Limited, Melbourne, Australia, 4Department of Radiology, The University of Melbourne, Melbourne, Australia, 5Cardiovascular Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, 6EMEA Scientific Partnerships, Siemens Healthcare GmbH, Erlangen, Germany Keywords: Lung, Lung, sms, functional, pulmonary Motivation: Pulmonary functional imaging is critical for diagnosing lung diseases. However, sequential acquisition of multiple slices hinder the investigation of concurrent breathing dynamics while prolonging the overall the acquisition time. Goal(s): Our goal is to investigate the use of simultaneous multi-slice (SMS) imaging as an alternative approach for accelerating dynamic acquisitions for functional lung imaging. Approach: We obtained dynamic images using bSSFP and GRE acquisitions at 1.5T, from two healthy volunteers. Afterwards, registered images were analyzed using dynamic mode decomposition to generate pulmonary ventilation and perfusion maps. Results: Functional maps were obtained using both pulse sequences with SMS in both sagittal and coronal views. Impact: Dynamic lung
imaging often requires multiple slices for volumetric coverage, which can be
time-consuming. Simultaneous
multi-slice (SMS) technique enables the acquisition of multiple slices at the
same time, thus enabling the observation of concurrent breathing dynamics in an
efficient manner. |
| 2912.
 | 137 | Acute disease severity is associated with increased pulmonary perfusion transit times at follow-up in male patients hospitalised with COVID-19. Laura Saunders1, Paul Hughes1, A. A. Roger Thompson1,2, Martin Brook1, David Capener1, Louise V Wain3, Rachael A Evans3, Christopher E Brightling3, C-MORE/PHOSP-COVID Collaborative Group4, Stefan Neubauer5, Betty Raman5, and Jim M Wild1
1The University of Sheffield, Sheffield, United Kingdom, 2National Institute for Health Research (NIHR) Sheffield Biomedical Research Centre (BRC), Sheffield Teaching Hospitals, Sheffield, United Kingdom, 3University of Leicester, Leicester, United Kingdom, 4Full group details can be found in Appendix 1 of https://doi.org/10.1016/S2213-2600(21)00383-0, Sheffield, United Kingdom, 5University of Oxford, Oxford, United Kingdom Keywords: Lung, COVID-19 Motivation: Perfusion disturbances can be observed up to a year after acute COVID-19 infection. Goal(s): Evaluate the relationship between pulmonary perfusion and sex, age and disease severity in patients hospitalised due to COVID-19. Approach: 198 patients hospitalised due to COVID-19 were recruited from 13 centres as part of the C-MORE study. 3T dynamic contrast enhanced lung perfusion imaging was acquired at follow-up. Results: Men previously hospitalised with severe COVID-19 showed increased pulmonary mean transit time (MTT) and more heterogenous pulmonary MTT at follow up compared to men with less severe disease. Disease severity was not associated with increased MTT at follow up in women. Impact: Dynamic contrast enhanced
lung perfusion imaging can identify prolonged pulmonary transit times in
patients hospitalised due to COVID-19 and demonstrates that at patient
follow-up pulmonary perfusion depends on patient sex, age and, in male
patients, acute disease severity. |
| 2913.
 | 138 | 129Xe lung ventilation imaging in patients with long COVID without prior respiratory disease Laura Saunders1, Guilhem Collier1, Laurie J Smith1, Helen Marshall1, Alberto Biancardi1, Demi Jakymelen1, Scarlett Strickland1,2, Lotta Gustafsson1,2, Ryan Munro1, Oliver Rodgers1, Neil Stewart1, Graham Norquay1, David Capener1, Alexander Horsley3, A A Roger Thompson1,2, and Jim Wild1
1The University of Sheffield, Sheffield, United Kingdom, 2National Institute for Health Research (NIHR) Sheffield Biomedical Research Centre (BRC), Sheffield Teaching Hospitals, Sheffield, United Kingdom, 3The University of Manchester, Manchester, United Kingdom Keywords: Lung, COVID-19 Motivation: It is unclear the extent to which abnormal lung ventilation is present in long COVID subjects without prior respiratory diseases. Goal(s): Evaluate 129Xe lung ventilation imaging in a cohort without prior respiratory disease, consisting of patients with long COVID (with and without dyspnea) and controls. Approach: 60 patients with long COVID (53 with dyspnea, 7 without dyspnea) and 20 controls underwent successful ventilation imaging and were included in analysis. Results: 129Xe ventilation imaging metrics did not find significant differences between controls and patients with long COVID, however a subset of long COVID patients with dyspnea had lung ventilation defects despite normal PFTs. Impact: Impact (40 words): The majority of patients with long COVID
have normal 129Xe lung ventilation imaging. 129Xe
ventilation imaging may be able to identify candidates with long COVID who may
be candidates for treatments targeted at airways disease. |
| 2914.
 | 139 | Phase-Resolved Functional Lung MRI Reveals Perfusion Abnormalities in Postacute COVID-19 Syndrome Tao Ouyang1, Andreas Voskrebenzev2, Jens Vogel-Claussen2, Chen Zhang3, and Qi Yang1
1Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China, Beijing, China, 2Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, Hannover, Germany, 3MR Research Collaboration, Siemens Healthineers, Beijing, China, Beijing, China Keywords: Visualization, Lung Motivation: The Pulmonary perfusion defects were unknown in post-acute COVID-19 syndrome (PACS). Goal(s): To investigate the utility of phase-resolved functional lung (PREFUL) MRI in detecting pulmonary perfusion disturbances inPACS. Approach: Participants diagnosed with PACS were recruited, along with healthy (NCT05933317). The quantified parameter QDP derived from PREFUL MRI represents abnormal pulmonary blood flow. Results: 44 participants with PACS, and 43 healthy were assessed. QDP significantly exceeded healthy controls in PACS (39.81% ± 15.0% vs 8.2% ± 3.3%) and was notably higher in inpatients (46.8% ± 17.0% vs 34.5% ± 10.8%). Moreover, males exhibited higher QDP than females (43.9% ± 16.8% vs 34.4% ± 10.2%). Impact: PREFUL
MRI demonstrates notable perfusion defects in participants with PACS. |
| 2915.
 | 140 | Correction of inhaled volume in 19F gas wash-in MRI for improved lung ventilation assessment Julienne Scheller1,2, Marcel Gutberlet1,2, Arnd Jonathan Obert3, Robin Aaron Müller1,2, Mark Greer4, Filip Klimeš1,2, Frank Wacker1,2, and Jens Vogel-Claussen1,2
1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 3Department of Radiation Oncology, University Hospital Würzburg, Würzburg, Germany, 4Department for Respiratory Medicine, Hannover Medical School, Hannover, Germany Keywords: Lung, Lung Motivation: In 19F MR pulmonary ventilation imaging, variations in inspiratory gas volumes can compromise the evaluation of dynamic ventilation parameters. Goal(s): To account for these variations, a correction of the inhaled volumes (CIV) can be applied during post-processing. Approach: This study examined the repeatability of dynamic ventilation parameters and the correlation with spirometric lung function testing with and without CIV in 24 patients with chronic obstructive pulmonary disease. Results: Using CIV increases the correlation of all assessed ventilation parameters with spirometry as well as their repeatability in terms of intraclass correlation coefficient and coefficient of variation between different scans. Impact: The increased repeatability and stronger correlation with spirometry suggest that the implementation of CIV can improve the evaluation of the pulmonary gas wash-in process retrospectively, without requiring additional MR scans or changes in the experimental procedure. |
| 2916.
 | 141 | Multi-Site Harmonization of Xe-129 MRI of Gas-Exchange & Ventilation: Clinical Study with E-Cigarette Users Jaime Mata1, John P. Mugler III1, Bastiaan Driehuys2, David Mummy2, Jamie MacLeod3, and Yun Michael Shim1,3
1Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, United States, 2Radiology, Duke University, Durham, NC, United States, 3Medicine, University of Virginia, Charlottesville, VA, United States Keywords: Lung, Hyperpolarized MR (Gas) Motivation: Study on the effects of e-cigarette use is needed to understand its damaging effects on the pulmonary system. Goal(s): Anticipating a need for multi-center clinical trials in the future this study, performed for the first time, studied the repeatability of Xe-129 gas-exchange MRI of the same subjects at two centers. Approach: Same subjects were imaged at University of Virginia and Duke University to directly assess technique harmonization and repeatability of Xe-129 metrics. Results: Note the statistically insignificant differences for each subject, for ventilation and gas-exchange, with signal-to-noise ratio for ventilation scans being the only statistically significant parameter (p=0.027) to differ between the sites. Impact: Harmonization of Xe-129 MRI gas-exchange and
ventilation imaging methodology among the two sites was successfully achieved,
opening the way for a large clinical trial with these two institutions. |
| 2917.
 | 142 | Using a Shinnar LeRoux Pulse for 3D Multi Ultra-short TE Look-locker Inversion Recovery for T1-Mapping in the human lungs Simon Michael Florian Triphan1,2, Ke Zhang1, Hans-Ulrich Kauczor1,2, and Mark Oliver Wielpütz1,2
1Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany, 2Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research, Heidelberg, Germany Keywords: Lung, Lung Motivation: Lung T1(TE) quantification using 2D UTE was demonstrated as an interesting tool but needs expansion to 3D UTE for better comparability and coverage. However, streaking artefacts originating from the edges of the Field of View are particularly problematic in Lung T1(TE) maps. Goal(s): To reduce streakings in T1(TE) maps caused by B0 inhomogeneities. Approach: A Shinnar LeRoux (SLR) minimum phase pulse was used to limit excitation to a 320mm slab in the Multi Ultra-short TE Look-Locker Inversion Recovery sequence. Results: T1(TE) maps produced using sagittal SLR excitation showed less streakings than using transverse SLR excitation and rectangular pulses, but still had residual streaking. Impact: Inhomogeneity streakings in 3D UTE lung T1(TE) maps were greatly reduced by employing a SLR pulse. With additional efforts during reconstruction, it may be possible to remove the remaining artefacts and quickly acquire parameter maps of the entire lungs. |
| 2918.
 | 143 | Pulmonary functional imaging for patients with obstructive lung disease using UTE MRI Li Fan1, Jie Li1,2, Yi Xia1, Pu-Yeh Wu3, Meiling Xu1, Guangyuan Sun4, and Shiyuan Liu1
1Department of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai, China, 2College of Health Sciences and Engineering, University of Shanghai for Science and Technology, Shanghai, China, 3GE Healthcare, Beijing, China, 4Department of Thoracic Surgery, Second Affiliated Hospital of Naval Medical University, Shanghai, China Keywords: Lung, Lung, UTE；fractional ventilation；pulmonary function tests； Motivation: This study aimed to assess the feasibility of using single breath-hold UTE MRI to quantify pulmonary function and its spatial uniformity in patients with obstructive lung disease. Goal(s): Comparison of FV in patients with different respiratory stages and correlation with PFTs. Approach: FV map was obtained from UTE MRI, and IQR of FV was calculated. Group differences of UTE parameters were compared, and correlation between UTE MRI with PFT parameters was assessed. Results: We found significant differences in whole lung FV and left lung FV among groups, with a positive correlation between FV and PFT parameters such as FEV1 and MMEF. Impact: This study demonstrates the potential of UTE MRI for assessing pulmonary function in obstructive lung disease patients. By providing regional functional information, UTE MRI might be a useful tool in lung disease management. |
| 2919.
 | 144 | MRS Investigations of the Metabolomic Pathophysiology of Acute Respiratory Distress Syndrome (ARDS) Ella Zhang1, Clara Benatzky1, Aaron Ziegler1, Li Su2, David C. Christiani2, and Leo L. Cheng1
1Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States Keywords: Lung, Spectroscopy, Metabolomic imaging, acute respiratory distress syndrome, nuclear magnetic resonance, metabolomics, metabolites Motivation: ARDS currently has unacceptable high mortality and long-term complications, which underscores the urgency of improving our understanding and management of ARDS. Goal(s): To establish pathology-guided serum metabolomic profiles for ARDS patients by comparing them with profiles from patients without ARDS. Approach: We measured ARDS serum using high-resolution magic angle spinning (HRMAS) magnetic resonance spectroscopy (MRS) to establish serum metabolomic profiles for ICU-patients with and without ARDS following various clinical outcomes. Results: Serum specimens measured by HRMAS MRS enables the predictions of ARDS patient outcome in ICU. Impact: Our initial results highlight the feasibility of HRMAS MRS in
investigating ARDS metabolomic mechanisms, which may lay the basis for future
diagnostic and therapeutic research, offering promising prospects for
innovation in ARDS management. |