| Computer # |
| 4623.
 | 145 | Effects of Kidney Perfusion levels on Renal Stiffness and Fluidity measured with Tomoelastography in an MRI-compatible ex-vivo model Johannes Castelein1, Carolina Pamplona1, Marina Vidal dos Santos 1, Roberto Armstrong-Jr 1, Cyril Moers1, Rudi Dierckx1, Ronald Borra1, and Ingolf Sack2
1University Medical Center Groningen, Groningen, Netherlands, 2University Hospital Charitè, Berlin, Germany Keywords: Kidney, Elastography Motivation: Tomoelastography allows for early detection of changes in the renal stiffness of various kidney pathologies. However, variations in tissue perfusion can have a strong impact on the assessment of renal stiffness. Goal(s): To characterize the effect of tissue perfusion on renal stiffness and tissue fluidity. Approach: Five ex vivo porcine kidneys were separately perfused in an MRI-compatible normothermic machine perfusion setup and simultaneously examined by Tomoelastography. Results: Our results show a strong positive correlation between increasing tissue perfusion and stiffness in the cortex and medulla of ex vivo porcine kidneys being observed after readily one minute of altered tissue perfusion. Impact: Stiffness is an essential
factor in diagnosing renal fibrosis. When the renal vasculature is
highly perfused, it can mimic increased stiffness associated with renal
fibrosis. Our study emphasizes the strong dependency
of renal stiffness and fluidity on perfusion. |
| 4624.
 | 146 | Test-Retest Reliability, Agreement, and Bias of Deep Learning Based Reconstructions for PDFF and R2* Quantification Hung Phi Do1, Jitka Starekova2, Vadim Malis3, Won Bae3, Dawn Berkeley1, Brian Tymkiw1, Wissam AlGhuraibawi1, Scott B Reeder2,4,5,6,7, Jean H Brittain8, Mo Kadbi1, and Diego Hernando2,4
1Canon Medical Systems USA, Inc., Tustin, CA, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Radiology, University of California San Diego, San Diego, CA, United States, 4Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 5Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 6Medicine, University of Wisconsin-Madison, Madison, WI, United States, 7Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States, 8Calimetrix, Madison, WI, United States Keywords: Liver, Body Motivation: Deep Learning Reconstruction (DLR) has been used routinely in clinical setting for qualitative weighted images. It is imperative to evaluate DLR for quantitative imaging prior to widespread clinical adoption. Goal(s): To assess the test-retest reliability of PDFF and R2* values calculated from DL-reconstructed images compared to those from the conventional reconstruction (CONV). Approach: A commercial PDFF/R2* phantom was imaged twice, with repositioning between acquisitions. Each scan was reconstructed with CONV and DLRs, which were used to calculate PDFF and R2* maps. Results: Excellent test-retest reliability for all three reconstructions with R2>0.99 and minimal bias (<0.58% for PDFF and <3.67 s-1 for R2*). Impact: SNR, resolution, and scan-time of quantitative MRI may benefit from DLR similarly as for qualitative MRI. This study showed that DLR has excellent test-retest reliability for PDFF/R2* quantification with minimal bias, providing foundational evidence for wider clinical adoption. |
| 4625.
 | 147 | Lipid composition mapping of the breast in BRCA1/2 genetic mutation carriers using chemical shift-encoded imaging Sai Man Cheung1, Kwok-Shing Chan2, Yazan Masannat3, Senthil Ragupathy4, Zosia Miedzybrodzka1, and Jiabao He1,5
1Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom, 2Massachusetts General Hospital, Boston, MA, United States, 3Breast Unit, Broomfield Hospital, Mid and South Essex NHS Trust, Chelmsford, United Kingdom, 4Radiology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 5Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle, United Kingdom Keywords: Screening, Fat, BRCA1/2, chemical shift-encoded imaging, early detection Motivation: Deregulation of lipid composition in the breast of BRCA1/2 carriers has been observed using single voxel spectral edited MRS, however the spatial distribution may further distinguish the disease state. Goal(s): We aimed to determine the power and repeatability of CSEI in detection of lipid deregulation in BRCA1/2. Approach: Lipid composition maps were acquired from 20 BRCA1/2 and 20 patients, to derive monounsaturated, polyunsaturated and saturated fatty acids in the peri-tumoural region in patients and the whole breast in all subjects. Results: Lipid composition in BRCA1/2 showed similarity to positive control. CSEI has excellent repeatability in lipid composition mapping of the breast. Impact: Deregulation of lipid composition in the breast of BRCA1/2 genetic mutation carriers resembles the diseased group, serving as potential precursor of breast cancer. CSEI yields highly repeatable quantitative maps of lipid composition critical for effective disease monitoring. |
| 4626.
 | 148 | What does liver R2* mean when iron levels are not elevated? Understanding the variation in R1 and R2* in the healthy liver Patrick W Hales1, Roberto Salvati1, Matthew Robson1, and Carolina C Fernandes1
1Perspectum, Oxford, United Kingdom Keywords: Liver, Liver, T1, T2*, R1, R2* Motivation: The influence of liver iron concentration (LIC) on liver R1 and R2* has been well described. However, in healthy subjects, R1 and R2* may be predominantly influenced by liver water content (LWC). The expected variability in R1 and R2* due to changes in LWC is not well understood.
Goal(s): Our goal was to model the expected variability in liver R1 and R2* due to changes in both LWC and LIC.
Approach: We developed a model, and tested the predictions against measured R1/R2* values in healthy subjects. Results: The model predictions showed good agreement with the measured data in the majority of healthy subjects. Impact: This work explains the variability
in liver R1 and R2* due to changes in liver water content (LWC) and iron. This could aid our interpretation of changes in these parameters in
subjects where LWC is clinically relevant. |
| 4627.
 | 149 | Optimization of Parallel Imaging in Flip Angle Modulated 2D Sequential CSE-MRI for SNR-Efficient and Motion-Robust Liver Fat Quantification Jiayi Tang1,2, Daiki Tamada2, Raphael do Vale Souza2, Aaron Faacks2, Garrett Fullerton1,2, Collin J Buelo1,2, Jitka Starekova2, Jeff Kammerman3, Jean H Brittain3, Scott B Reeder1,2,4,5,6, and Diego Hernando1,2
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Calimetrix, LLC, Madison, WI, United States, 4Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 5Medicine, University of Wisconsin-Madison, Madison, WI, United States, 6Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States Keywords: Liver, Fat, data acquisition, liver, pulse sequence design, parallel imaging Motivation: Flip-angle modulation (FAM) in a 2D sequential acquisition is one potential means to improve the motion-robustness and SNR of CSE-MRI for liver fat quantification, and the motion-robustness and SNR-efficiency of FAM can be further improved through parallel imaging and capturing respiratory motion in-plane. Goal(s): To determine the feasibility and performance (with respect to SNR, repeatability, and bias) of FAM-based free-breathing liver fat quantification acquired across imaging orientations and accelerations. Approach: Trials of various parameters of FAM in volunteers and in a phantom with controlled PDFF and T1 values. Results: Accelerated FAM demonstrates few artifacts, low bias, and increased SNR-efficiency compared to unaccelerated FAM. Impact: Increasing the motion-robustness and SNR-efficiency of FAM may enable and enhance its use for improved detection, staging, and monitoring of steatotic liver disease. Non-axial acquisitions may mitigate through-plane respiratory motion compared to axial acquisitions. |
| 4628.
 | 150 | Identification of Early-stage Renal Abnormalities by Magnetic Resonance Imaging in Chronic Heart Failure Patients: A Preliminary Study Kaiming Xue1, Lin Liu1, Yueluan Jiang2, Kühn Bernd3, and Mengchao Zhang1
1China-Japan Union Hospital of Jilin University, Changchun, China, 2MR Research Collaboration, Siemens Healthineers, Beijing, China, 3MR Application Predevelopment, Siemens Healthineers AG, Erlangen, Germany Keywords: Kidney, Kidney Motivation: The prevalence of impaired renal function is high in chronic heart failure (HF). However, renal abnormalities are faced with difficulties in early diagnosis. Goal(s): Identification of preclinical pathophysiological changes of kidney by multiparametric MRI in chronic HF patients. Approach: Chronic HF with eGFR>60 ml/min/1.73 m2 and healthy volunteers underwent multiparametric MRI. RBF, T1 relaxation time, T2 relaxation time, R2*, and ADC values of renal cortex were measured and compared between the patients and controls. Results: Chronic HF group demonstrated higher R2* values (p=0.043) and lower RBF values (p<0.01) than control group. The other three parameter values showed no statistically significant difference between groups. Impact: In this preliminary study, we revealed that even with preserved estimated glomerular filtration rate (eGFR), patients with chronic heart failure demonstrated subclinical pathophysiological, including decreased perfusion and hypoxia. The association could be a potential target for diagnosis and protective treatment. |
| 4629.
 | 151 | Quantifying liver fibrosis via diamagnetic susceptibility sources using MRI: An ex-vivo feasibility study. Chao Li1,2, Jinwei Zhang1,3, Jiahao Li1,3, Anne K. Koehne de González4, Martin R. Prince1, Gary M. Brittenham5, Pascal Spincemaille1, Thanh D. Nguyen1, and Yi Wang1
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Applied and Engineering Physics, Cornell Univeristy, Ithaca, NY, United States, 3Meinig School of Biomedical Engineering, Cornell Univeristy, Ithaca, NY, United States, 4Department of Pathology, Columbia University Medical Center, New York, NY, United States, 5Department of Pediatrics, Columbia University, New York, NY, United States Keywords: Liver, Liver Motivation: Liver biopsy, traditionally regarded as the benchmark for liver fibrosis staging, is an invasive procedure that may cause infection and bleeding. Goal(s): To develop a non-invasive method to evaluate liver fibrosis using MRI. Approach: Diamagnetic sources are separated from paramagnetic sources using a biophysical model and multi echo gradient echo data. The value of the diamagnetic sources can be used to quantify the amount of accumulation of collagen due to liver fibrosis. Results: Significant differences in liver negative susceptibility were observed between lower stage, medium stage and higher stage of fibrosis. Impact: Multi-echo
gradient echo data may provide a way to non-invasively stage liver fibrosis. |
| 4630.
 | 152 | Improving Self-Gated Radial MR Elastography for Free-Breathing Quantification of Liver Stiffness in Children Sevgi Gokce Kafali1,2, Bradley D. Bolster Jr.3, Shu-Fu Shih1,2, Timoteo I. Delgado1,4, Vibhas Deshpande5, Xiaodong Zhong1, Timothy R. Adamos6, Shahnaz Ghahremani1,6, Kara L. Calkins6, and Holden H. Wu1,2,4
1Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3US MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Salt Lake City, UT, United States, 4Physics and Biology in Medicine Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, United States, 5US MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Austin, TX, United States, 6Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States Keywords: Liver, Pediatric Motivation: MR elastography (MRE) detects liver fibrosis by measuring hepatic stiffness (HS). Breath-holding (BH) is required to avoid motion artifacts, but this is challenging in children. Previous radial free-breathing (FB) MRE eliminated the BH, but required 2 min/slice. Goal(s): To reduce scan time for radial FB-MRE and analyze the effects of self-gating on HS. Approach: Radial FB-MRE was modified to acquire lower resolution and perform spatial interpolation, which reduced the scan time. Self-gating was performed to compensate for breathing motion. Results: In 23 children, self-gated radial FB-MRE (1 min/slice) yielded more accurate and repeatable HS than non-self-gated radial FB-MRE, with respect to standard BH-MRE. Impact: Self-gated free-breathing MR elastography (MRE) of the liver produced accurate and repeatable hepatic stiffness in 1 min/slice, with respect to standard cartesian breath-held MRE, and can be beneficial for children who cannot perform breath-holding. |
| 4631.
 | 153 | Assessing Renal Interstitial Fibrosis by Compartmental, Non-Compartmental, Model-Free Diffusion MRI and Their Corticomedullary Difference Wentao Hu1, Yongming Dai2, Fang Liu1, Dongmei Wu3, Minfang Zhang4, and Yan Zhou1
1Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, 3Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronics Science, East China Normal University, Shanghai, China, 4Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Keywords: Kidney, Kidney Motivation: Non-invasive evaluation of chronic kidney disease (CKD) is of increasing value. Goal(s): This study aims to assess renal interstitial fibrosis (IF) using diffusion-based MRI approached and their corticomedullary difference (CMD) in CKD patients. Approach: MRI parameters from apparent diffusion coefficient (ADC), intra-voxel incoherent motion (IVIM), diffusion kurtosis imaging (DKI) and diffusion-relaxation correlated spectrum imaging (DR-CSI) were obtained both for renal cortex and medullary. CMD of these parameters were calculated. Results: Several diffusion-based MRI parameters are promising for differentiating between the mild and moderate-severe renal IF. CMD shows potential for the assessment of renal IF on a supplementary role. Impact: This study shows attempts on non-invasive
assessment of renal interstitial fibrosis using several typical advanced model
or model-free methods regarding diffusion MRI. Also, it illustrates the
possible role of renal corticomedullary difference of these approaches in the
assessment. |
| 4632.
 | 154 | Free-breathing 3D Radial DIXON Look-Locker sequence for whole-liver simultaneous quantification of water/fat separated T1 and PDFF Yu Ueda1, Yoshihiko Fukukura2, Kazunori Moriya2, Shigeru Shibata2, Kota Amo1, Makoto Obara1, Masami Yoneyama1, Jihun Kwon1, Tsutomu Tamada2, and Marc Van Cauteren3
1Philips Japan, Tokyo, Japan, 2Department of Radiology, Kawasaki Medical School, Okayama, Japan, 3Philips Healthcare, Tokyo, Japan Keywords: Liver, Liver Motivation: T1 and PDFF mapping, which could serve as imaging biomarkers for liver disease, require breath-holds; T1 mapping commonly used in clinical practice, such as MOLLI, has limited spatial coverage. In addition, the presence of liver fat reduces T1 accuracy. Goal(s): Our goal is to enable simultaneous whole liver water/fat separated T1 and PDFF quantification with clinically acceptable accuracy without breath-holds. Approach: We introduced the 3D Radial DIXON LL sequence and validated in phantom and in vivo. Results: Free-breathing 3D Radial Dixon LL sequence results in a proportional bias for T1 measurement and the fixed bias for PDFF measurement compared to current standard techniques. Impact: The 3D
Radial Dixon LL sequence did not result in sufficiently good agreement with
reference methods for water/fat separated T1 and PDFF,
suggesting that further technical validation and the optimization of imaging
parameters will be needed. |
| 4633.
 | 155 | Preliminary feasibility study of localized 31P spectroscopy in normal human pancreas at 3 Tesla Zhongping Zhang1, Yinghua Guo1, Yiming Wang1, Yanzhao Yang2, and Weimin Chai2
1Philips Healthcare, Shanghai, China, 2Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Keywords: Pancreas, Pancreas, Multi-nuclei, Phosphorus, Feasibility, Phosphomonoester, Phosphodiester Motivation: Phosphorus (31P) MR spectroscopy is quite challenging in deeply lying pancreas due to limited coil sensitivity. To our knowledge, its feasibility at 3T has not been reported yet. Goal(s): This study aims to investigate the feasibility of localized 31P magnetic resonance spectroscopy of normal human pancreas at 3T. Approach: 2D CSI 31P spectroscopy sequence were applied on pancreas of 4 healthy volunteers and phosphate metabolite ratios were calculated. Results: 31P spectrum acquired from one normal pancreas achieved comparable quality and similar PME/PDE ratio to a previous pancreas 31P spectroscopy report at 7T. Others failed due to severe contamination from neighboring muscle or gallbladder. Impact: In one among the four attempts, we obtained good 31P spectrum and PME/PDE ratio in normal pancreas. Despite low success rate, this preliminary exploration showed that localized 31P spectroscopy of human pancreas at 3T is promising although challenging. |
| 4634.
 | 156 | Evaluation of MRS- and MRI- PDFF and Liver Biopsy measure of hepatic fat fraction in a clinically relevant cohort Christian Simonsson1,2,3, Shan Cai1,2, Jens Tellman1, Markus Karlsson1,4, Gunnar Cedersund2,3, Simone Ignatova5, Patrik Nasr6, Mattias Ekstedt2,6, Stergios Kechagias2,6, Nils Dahlström2,7, and Peter Lundberg1,2
1Department of Radiation Physics, Radiology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 3Department of Biomedical Engineering, Linköping University, Linköping, Sweden, 4AMRA Medical AB, Linköping, Sweden, 5Department of Clinical Pathology and Clinical Genetics, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden, 6Department of Gastroenterology and Hepatology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, 7Department of Radiology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden Keywords: Liver, Liver Motivation: Metabolic Associated Fatty Liver Disease (MAFLD) will increase the burden on future healthcare. Reliable screening alternatives such as MR-techniques e.g., nP-Dixon imaging and proton MR-spectroscopy are widely used. However, the number of studies comparing both MR-techniques with biopsies in clinically relevant cohorts is limited. Goal(s): Compare MR Dixon imaging and proton MR-spectroscopy fat fraction with histological evaluation of steatosis Approach: We have compared three different PDFF measurements; MRS, 6- and 2-point Dixon PDFF, in a prospective study, which included 84 clinically relevant patients with diffuse liver disease. Results: All three techniques could accurately characterize histology based steatosis scores in this clinically relevant cohort. Impact: In
this prospective study, with a clinically relevant cohort, a difference between
MRS and Dixon determined PDFF was measured. Both methods could distinguish
between different histological levels of steatosis, and both methods could therefore
characterize the patient group accurately. |
| 4635.
 | 157 | Multiparametric MRI based assessment of kidney injury in a mouse model of ischemia reperfusion injury Sourav Bhaduri*1,2, Soham Mukherjee*3, Rachel Harwood4, Patricia Murray5, Bettina Wilm6, Rachel Bearon7, and Harish Poptani3
1Symbiosis Centre for Medical Image Analysis, Symbiosis International University, Pune, India, 2Institute for Advancing Intelligence, TCG Crest, Kolkata, India, 3Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom, 4University of Liverpool, Liverpool, United Kingdom, 5Department of Women’s and Children’s health, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, University of Liverpool, Liverpool, United Kingdom, 6Department of Women’s and Children’s health, University of Liverpool, Liverpool, United Kingdom, 7Mathematical Sciences, University of Liverpool, Liverpool, United Kingdom Keywords: Kidney, Kidney, Multiparametric MRI, IRI Motivation: Assessment of kidney health is paramount for early diagnosis of impairment and subsequent methods of intervention. Goal(s): This study enhances our understanding of kidney pathophysiology using multiparametric MRI analysis Approach: Parsimonious pharmacokinetic modelling of the DCE-MRI data along with ASL and DWI was used to assess longitudinal changes in glomerular filtration rate (GFR) and kidney function in a mouse model of ischemia reperfusion injury. Results: Findings suggest that Renal Blood Flow (RBF), parsimonious filtration quotient (Ft), GFR, kidney volume, and Apparent Diffusion Coefficient (ADC) are important in comprehending the renal effects induced by ischemia reperfusion injury. Impact: This study provides an improved understanding of
renal pathophysiology and underscores the value of multi-parametric MR imaging for
assessing early changes in kidney function due to IRI,
which may aid in early diagnosis of kidney injury and monitoring treatment response. |
| 4636.
 | 158 | Diffusion-weighted MRI-based Virtual Elastography for the Assessment of Liver Fibrosis Fengxian Fan1, YanLi Jiang1, Pin Yang1, Jie Zou1, Shaoyu Wang2, and Jing Zhang1
1Lanzhou University Second Hospital, Lanzhou, China, 2Siemens Healthcare, Shanghai, China Keywords: Liver, Diffusion/other diffusion imaging techniques Motivation: Liver biopsy is considered the reference standard for liver fibrosis quantification, however, noninvasive techniques are the emerging focus in this field. Elasticity values based on Diffusion-weighted (DW) MRI–based virtual elastography has been confirmed of a highly correlation with MR elastography. Goal(s): Assess the usefulness of DW MRI-based virtual MR elastography in the evaluation of fibrosis. Approach: We compared the diagnostic performance of elasticity values based on virtual MR elastography(μDiff), US elastography (Fibroscan) and serum markers for identifying significant liver fibrosis. Results: μDiff were significantly different between non-significant and significant fibrosis, and slightly accurate than Fibroscan for depiction of significant fibrosis. Impact: Diffusion-weighted MRI–based virtual elastography was confirmed with good agreement with shear modulus measured at MR elastography. Our study found that virtual modulus were significantly different between non-significant and significant liver fibrosis and appeared to preoperative prediction of liver fibrosis. |
| 4637.
 | 159 | Accelerated Abdominal 3D T1rho Mapping using Diamond Radial Sampling Sandeep Panwar Jogi1, Qi Peng2, Ramin Jafari3, Ricardo Otazo1,4, and Can Wu1
1Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States, 3MR Clinical Science, Philips Healthcare, Cambridge, MA, United States, 4Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States Keywords: Liver, Quantitative Imaging, T1rho, Abdomen, Radial, Free-breathing, Motion Motivation: Current T1rho mapping of the abdomen is performed using breath-hold, respiratory triggering, or stack-of-stars acquisitions, which have limited spatial resolution and coverage or require a long scan time. Goal(s): To develop accelerated free-breathing 3D T1rho mapping technique for the abdomen using efficient diamond sampling. Approach: Free-breathing 3D T1rho imaging was performed on six volunteers using the MAPSS sequence. T1rho values were compared between stack-of-stars and diamond sampling. Results: The scan time was reduced from 5:24min per TSL for stack-of-stars to 2:26min per TSL for diamond sampling. The T1rho values obtained with both methods were comparable. Impact: The
proposed free-breathing 3D T1rho mapping of the abdomen with accelerated
diamond sampling has the potential to provide a quantitative assessment of abdominal
lesions for improved diagnosis and treatment response evaluation. |
| 4638.
 | 160 | Diffusion and Perfusion Measurements of Uterine Corpus Fluctuate During Menstrual Cycle: an IVIM based study Lei Deng1, Wanxu Ren2, Ali Shang1, Xiaocheng Wei3, Xiaohui Li1, and Quanxin Yang1
1The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, 2Xian Yang Central Hospital, Xian Yang, China, 3GE HealthCare MR Research, Beijing, China Keywords: Uterus, Perfusion Motivation: Correct identification of the typical appearance of the distinct uterine corpus layers during the menstrual cycle is crucial for evaluating uterine lesions. Goal(s): To investigate the diffusion and perfusion of uterine corpus fluctuate during menstrual cycle. Approach: Thirty-one volunteers underwent standard pelvic IVIM-DWI in menstrual period, mid-proliferative period and mid-secretory period. The differences of D, D*, f and f ×D* among three-layer structure or different menstrual period were compared. Results: It was found that an exacerbation of diffusion restriction, occurring from the menstrual period to the mid-secretory period, and perfusion driven by IVIM of uterine corpus was generally decreased, especially in endometrium. Impact: Considering the menstrual status is necessary on assessment of uterine lesions. It is recommended to study uterine lesions within the same menstrual cycle. |