| Computer # |
| 4751.
 | 113 | New Dual-Element 13C/1H Endorectal Coil for Improving mpMR-TRUS Guided Fusion Prostate Biopsies With Hyperpolarized C-13 Molecular Imaging Daniel T Gebrezgiabhier1,2, Lucas Carvajal3, Hsin-Yu Chen1, Yaewon Kim4, Robert A Bok3, Matthew R Cooperberg5, Hao G Nguyen4, Katsuto Shinohara5, Kimberly Okamoto3, Mary Frost3, Zhen Wang3, Michael Ohliger3, Jeremy Gordon3, Peder Larson3, Rahul Aggarwal5, and Daniel Vigneron6
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, United Kingdom, 2Bioengineering, University of California, San Francisco, San Francisco, CA, United States, 3Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 4University of California, San Francisco, San Francisco, CA, United States, 5School of Medicine, University of California, San Francisco, San Francisco, CA, United States, 6Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States Keywords: Prostate, Hyperpolarized MR (Non-Gas), TRUS guided biosy Motivation: To address the issues with the original dual-element 13C/1H endorectal coil (ERC). Goal(s): We designed and fabricated a novel dual-element 13C/1H ERC, validated with bench testing and then evaluated in 3T MRI studies. Approach: Phantoms were imaged using the new ERC and the original ERC. Acquired data was then analyzed and respective SNR compared. Results: The new ERC demonstrated substantially improved 13C and 1H MRI sensitivity on bench electronic testing. In addition, the new ERC demonstrated substantial improvement in signal-to-noise ratio, and since the coil has successfully been used in hyperpolarized 13C-pyruvate, co-polarized 13C-urea+pyruvate multiparametric MRI patient studies for guiding prostate cancer biopsy. Impact: Hyperpolarized 13C MRI, RF Coils, Metabolic imaging, Molecular imaging, Endorectal coil |
| 4752.
 | 114 | Unified Shimming and RF coil (UNIC) Reduces Susceptibility Artifacts in Prostate DWI in Subjects with Metallic Hip Prosthesis at 3T Ziyang Long1,2,3, Archana Malagi1, Fardad Michael Serry1, Liting Huang1, Mohammed Albatany1, Jeremy Zepeda1, Lingceng Ma1, Chia-Chi Yang1, Lixia Wang1, Nader Binesh4, Yujie Shan1, Debiao Li1,3, Hsin-Jung Yang1, and Hui Han1,2
1Biomedical Imaging Research Institude, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 3Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 4Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, United States Keywords: Prostate, Shims, Metallic Artifacts, Hip Prosthesis Motivation: Metallic implants in the body may cause severe image artifacts. Goal(s): To improve prostate DWI imaging in patients with metallic hip replacement using a novel B0 local shimming system. Approach: Unified Shimming and RF coil (UNIC) arrays were used to improve local B0 shimming. Improved DWI image quality was assessed at 3T MRI on subjects with hip prostheses. Results: UNIC arrays significantly improved B0 homogeneity and reduced DWI distortions in prostate, resulting in improved Dice and Jaccard coefficients. Impact: UNIC coil arrays can enable 3T prostate
DWI MRI for patients with metallic hip implants
and provide the necessary care for the fast-growing population. |
| 4753.
 | 115 | Low field (60mT) MRI using flexible coil for prostate imaging Jae Eun Song1, Jeremy Sharkey1, Maryamsadat Shokrekhodaei1, Meredith Sadinski1, Muller De Matos Gomes1, Scott B. King1, and Aleksandar Nacev1
1Promaxo, Inc., Oakland, CA, United States Keywords: Prostate, Prostate Motivation: The low field (60mT) MRI system offers advantages such as affordability and portability. Goal(s): To develop flexible coils for low field (60mT) MRI to improve image quality. Approach: Designing a multi-channel receive coil using flexible body coil technology, allowing improved workflow, close proximity to the patient's body and improved SNR. Results: The flexible coil demonstrated higher SNR in phantom experiment, enhancing image quality and enabling visualization of previously undetected areas in in-vivo experiment. Impact: The advancements in flexible coils have the potential to improve image guided procedures, facilitating accurate targeted biopsies and ultimately improving patient outcomes. |
| 4754.
 | 116 | Longitudinal 129Xe MRI Gas-exchange and Exercise Intolerance in Long-COVID Natally AlArab1, Marrissa J McIntosh1, Andrew D Hahn2, Nicholas D Feeley3, Keegan R Staab4, Jonathan L Percy5, Conner J Wharff1, Jessica C. Sieren1,4, Alejandro Comellas6, Eric A. Hoffman1,4, and Sean B. Fain1,4
1Department of Radiology, University of Iowa, Iowa City, IA, United States, 2Department of Iowa, University of Iowa, Iowa City, IA, United States, 3Institute for Clinical and Translational Sciences, University of Iowa, Iowa City, IA, United States, 4Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, United States, 5Department of Physics, University of Iowa, Iowa City, IA, United States, 6Department of Internal Medicine, University of Iowa, Iowa City, IA, United States Keywords: Lung, COVID-19, Hyperpolarized Xenon MRI, Long COVID, Exercise tests Motivation: Long-COVID symptoms are experienced by 10-20% of COVID-19 patients. 129Xe MRI ventilation and gas-exchange measurements may provide insights into long-COVID-19 patients' recovery. Goal(s): Use 129Xe MRI to monitor longitudinal recovery (>1 year following infection) of long-COVID patients. Approach: Thirteen long-COVID participants were evaluated longitudinally using pulmonary function tests, six-minute walk distance (6MWD), quality-of-life, and 129Xe MRI imaging measurements. Results: Improvements in FEV1 and FVC%pred, dyspnea following exercise, and clinically significant improvements in 6MWD were observed. No significant differences in imaging measurements were observed between visits or between COVID and control groups. Dyspnea and MRI gas-exchange were correlated. Impact: 129Xe MRI measurements
in long-COVID participants suggest persistent gas-exchange abnormalities and
exercise intolerance, offering valuable insights for future management and
rehabilitation of these patients. |
| 4755.
 | 117 | Comparison of dissolved xenon imaging methods: 2D CSI vs 4-echo flyback radial spectroscopic imaging. Guilhem Collier1, Neil J. Stewart1, Graham Norquay1, Laurie J. Smith1, and Jim M. Wild1
1POLARIS, Division of Clinical Medicine, University of Sheffield, Sheffield, United Kingdom Keywords: Lung, Hyperpolarized MR (Gas) Motivation: Several dissolved xenon imaging methods have been proposed to detect impaired gas transfer in the lung. However, none have been validated against a gold standard CSI sequence. Goal(s): To validate quantitative xenon gas exchange metrics from a 4-echo radial EPSI implementation against those from CSI. Approach: 4-echo radial EPSI results were compared to CSI in 2 healthy volunteers. Results: We found good correlations between xenon gas exchange metrics from CSI and radial EPSI and minimal biases (0.4 to 5.8%) between the two methods for the main outcome parameter RBC:M, the ratio of dissolved xenon signals from the blood and in the membrane. Impact: Our implementation of dissolved xenon imaging using a 4-echo
radial EPSI is validated against the reference standard CSI sequence, providing
confidence in the quantitative nature of the xenon gas exchange metrics from
this method to assess lung diseases. |
| 4756.
 | 118 | Regional quantification of 129Xe Gaussian broadening in the lungs with time-domain Voigt fitting of 3D CSI Graham Norquay1, Guilhem J Collier1, and Jim M Wild1,2
1POLARIS, Division of Clinical Medicine, University of Sheffield, Sheffield, United Kingdom, 2Insigneo Institute, University of Sheffield, Sheffield, United Kingdom Keywords: Lung, Hyperpolarized MR (Gas) Motivation: Frequency-domain dissolved 129Xe CSI suffers from low spectral resolution, which can result in inaccuracies in the fitted spectral parameters. Time-domain Voigt fitting of CSI can improve accuracy and enable regional quantification of Gaussian broadening of 129Xe lung spectra. Goal(s): To quantify regional Gaussian broadening of 129Xe resonances in the lung airspaces and adjacent lung parenchyma. Approach: Time-domain Voigt fitting was performed on 129Xe 3D CSI data from the lungs of healthy volunteers. Results: Gaussian broadening contributed to 75-80% and 45% of the total linewidth for the gas and membrane 129Xe resonances, respectively, over all healthy volunteers. Corresponding Voigt T2 values were also quantified. Impact: We have demonstrated regional quantification of 129Xe
Gaussian broadening in the lungs. Knowledge of this should enhance accuracy of
spectral parameters computed for lung disease metrics while offering potential
utility as a metric itself. |
| 4757.
 | 119 | Assessing Pulmonary Function: A Comparative Study at 0.55T and 1.5T Rui Wang1, Qifan Ma1, Mengxiao Liu2, Yang Song3, Robert Grimm4, Voskrebenzev Andreas5, Vogel-Claussen Jens5, Ying Yuan1, and Xiaofeng Tao1
1Department of Radiology, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine., Shang hai, China, 2MR scientific Marketing,Diagnostic Imaging, Siemens Healthineers Ltd, Shanghai, China, Shang hai, China, 3MR Research Collaboration Team, Siemens Healthineers Ltd. Shanghai, China., Shang hai, China, 4MR Application PredevelopmentResearch Collaboration CLS BODY, Siemens Healthineers AG, Erlangen, Germany, Erlangen, Germany, 5Institute for Diagnostic and Interventional Radiology, Hannover Medical School, OE 8220, Carl-Neuberg-Str.1, 30625 Hannover, Germany., Hannover, Germany Keywords: Lung, Lung, PREFUL MRI Motivation: The motivation for this study is to develop a non-invasive imaging technique for assessing pulmonary function without the need for ionizing radiation or potentially harmful contrast agents. Goal(s): To evaluate the impact of different magnetic field strengths (0.55T and 1.5T) on functional parameters derived from the PREFUL MRI technique. Approach: The study analyzed the data with MRLung software and conducting statistical comparisons to assess the differences in functional parameters, SNR, and CNR between the two field strengths. Results: VDP, mean perfusion, and mean ventilation exhibited significant changes at the lower field strength, with higher SNR at 0.55T compared to 1.5T. Impact: We
demonstrate the potential of using a lower field strength (0.55T) MRI system
for assessing pulmonary function, offering insights into the impact of field
strength on functional parameters and quality, which may have
implications for improving non-invasive pulmonary imaging methods. |
| 4758.
 | 120 | 3D Diffusion-Prepared FLASH for Prostate MRI Near Metallic Implants Jeremiah Joseph Hess1,2, Philip Kenneth Lee1, Andrew Anthony Gomella1, Andreas Markus Loening1, and Brian Andrew Hargreaves1,2,3
1Radiology, Stanford University, Stanford, CA, United States, 2Bioengineering, Stanford University, Stanford University, CA, United States, 3Electrical Engineering, Stanford University, Stanford, CA, United States Keywords: Prostate, New Signal Preparation Schemes Motivation: Diffusion weighted imaging (DWI) is critical for prostate MRI, but echo planar imaging (EPI) DWI suffers from severe distortion in patients with hip implants or excessive bowel gas, often rendering images unusable. Goal(s): To develop 3D DWI of the prostate with minimal distortion from nearby metal. Approach: We compared a diffusion prepared, phase-navigated, fast low-angle shot (FLASH) readout sequence to EPI DWI to assess image quality, distortion correction and diffusion contrast. Results: Phantom experiments demonstrate the reduced FOV, distortion correction and ADC accuracy. Images in human subjects avoid the severe signal loss and distortion of EPI DWI in the subject with metal. Impact: We showed that 3D diffusion-prepared
FLASH enables DWI where EPI often fails near hip replacements. Increased robustness of prostate imaging
protocols to the presence of metal and/or bowel gas may obviate the need for
contrast injection in these patients. |
| 4759.
 | 121 | Functional lung imaging with ultrashort echo times achieved by half pulses Anne Slawig1,2,3, Andreas Max Weng3, and Herbert Köstler3
1Medical Physics Group, University Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Halle (Saale), Germany, 2Halle MR Imaging Core Facility, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany, 3Department of Diagnostic and Interventional Radiology, University Hospital Wuerzburg, Wuerzburg, Germany Keywords: Lung, Lung Motivation: While ventilation and perfusion mapping in lung can be realized by Cartesian imaging, low signal intensities, due to rapid relaxation, remain challenging and ultrashort echo times might improve robustness. Currently, the promising approach of half pulse excitation for 2D-UTE imaging was not yet employed for functional lung imaging. Goal(s): To evaluate the suitability of half pulse excitation for functional lung imaging. Approach: Functional lung imaging was performed in a healthy volunteer by radial acquisitions after sinc or half pulse excitation. Results: Complex sum of two half pulse acquisitions provides morphological depiction of lung tissue and ventilation maps, but no information on lung perfusion. Impact: The use of half pulses for functional lung imaging did not provide an improvement, as no information on perfusion can be gained. Therefore, other approaches are necessary to improve robustness in the detection of pathologies characterized by ventilation-perfusion mismatches. |
| 4760.
 | 122 | Temporal profile block-matching denoising enables free-breathing dynamic 19F lung MRI with sub 0.5 second acquisition time Truc Nguyen1, Khoi Huynh2, Sang Hun Chung1, Pew-Thian Yap1,2, and Yueh Z. Lee1,2
1Biomedical Engineering Department, UNC Chapel Hill, Chapel Hill, NC, United States, 2Department of Radiology and BRIC, UNC Chapel Hill, Chapel Hill, NC, United States Keywords: Lung, Lung, Free-breathing, 19F, denoising,cystic fibrosis Motivation: 19F pulmonary MRI is often used to characterize abnormalities in case of cystic fibrosis but its long scan time requires patients to hold their breath, which is uncomfortable and complicates acquisition. Goal(s): We introduce a denoising method to be used with fast 19F imaging that will enable free-breathing dynamic imaging.
Approach: 12 subjects underwent both conventional breath-hold and fast free-breathing imaging. Temporal block-matching denoising was done for free-breathing images.
Results: Our denoising method enables free-breathing dynamic 19F lung imaging. Images are recovered from the noise floor and show similar characteristics to conventional breath-hold imaging. Impact: Our denoising method enables free-breathing 19F dynamic lung imaging with sub 0.5 second acquisition time. Free-breathing imaging will increase patient comfort and potentially extend ventilation MRI use to more patients, including those with severe lung disease. |
| 4761.
 | 123 | Repeatability of Standalone versus Image-Acquisition-Integrated 129Xe Spectroscopy Yi Zheng1, Shuo Zhang2, Anna Costelle2, Aryil Bechtel2, John P. Mugler III3, David Mummy2, and Bastiaan Driehuys2
1Tanwei College, Tsinghua University, Beijing, China, 2Department of Radiology, Duke University, Durham, NC, United States, 3Department of Radiology & Medical Imaging, Charlottesville, VA, United States Keywords: Lung, Hyperpolarized MR (Gas) Motivation: 129Xe spectral parameters of lung airspaces, membrane tissues and red blood cells (RBC), provided by an MRS calibration scan, are important indicators of gas exchange function. Goal(s): Currently, such spectra are often acquired separately from gas exchange images, but it may be feasible to integrate 129Xe gas-exchange MRI and MRS into one scan, and test its repeatability. Approach: In this study, we assess the performance of image-acquisition-integrated spectra and compare them with a dedicated spectroscopicacquisition. Results: In subjects with a range of diseases, image-acquisition-integrated spectra were less repeatable than dedicated ones. However, increasing the number of averaged FIDS to 1second may yield equivalent performance. Impact: The repeatability of 129Xe spectroscopy integrated with imaging would be improved by collecting and averaging at least 1 second of data. |
| 4762.
 | 124 | Validation of mDixonQuant and IntelliSpace Portal for Liver Iron Estimation Eamon C Doyle1, Johannes M Peeters2, Pedro Rodrigues2, and John C Wood3
1Radiology, Children's Hospital of Los Angeles-USC KSOM, Los Angeles, CA, United States, 2Philips Medical Systems, Best, Netherlands, 3Pediatrics and Radiology, Children's Hospital of Los Angeles-USC KSOM, Los Angeles, CA, United States Keywords: Liver, Relaxometry, Iron Overload, Dixon Motivation: Simultaneous estimation of fat, water, and iron concentrations by MRI are now available on all three major MRI vendors, but the predicted liver iron concentration (LIC) values are sparsely validated. Goal(s): To cross validate LIC estimates generated by Philips mDixonQuant and IntelliSpace Portal (ISP) against LIC values measured by biopsy-validated, reference R2* and R2 methods Approach: 51 subjects underwent MRI for clinical purposes, with collection of mDixonQuant, standard multiple-echo gradient echo, and Ferriscan R2 images. Results: R2* values generated by the default mDixonQuant and ISP packages yielded accurate LIC estimates using the Garbowski calibration for LIC < 25 mg/g. Impact: This work allows mDixonQuant and ISP to be used with confidence in the clinical setting to quantify liver siderosis in most subjects referred for iron quantification. |
| 4763.
 | 125 | Retrospective Multisite Multisoftware Analysis of Intravoxel Incoherent Motion (IVIM) Breast MRI Dibash Basukala1, Artem Mikheev1, Nima Gilani1, Linda Moy1, Katja Pinker2, Savannah C. Partridge3, Debosmita Biswas3, Mami Iima4, Tone F. Bathen5, Sunitha B. Thakur2, and Eric E. Sigmund1
1Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 2Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Department of Radiology, University of Washington, Seattle, WA, United States, 4Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto, Japan, 5Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway Keywords: Breast, Data Analysis, Breast Tumor Motivation: Intravoxel incoherent motion (IVIM) MRI is helpful in breast tumor characterization, but variable performance exists in the literature. Goal(s): Translational assessment of multisite breast lesion data based on the 1st order radiomics features from each IVIM parameters perfusion fraction (fp), pseudodiffusivity (Dp) and tissue diffusivity (Dt) derived from multiple software platforms. Approach: This work used retrospective anonymized breast MRI data from three sites employing three different software to estimate the 1st order radiomics of fp, Dp and Dt, their software robustness, and diagnostic utility. Results: Dtmean, Dtminimum, and fpmean showed robustness across site/software; and Dtmean, Dtminimum showed highest and most consistent diagnostic utility. Impact: Multiple 1st
order radiomics features of tissue diffusivity (Dt) or perfusion fraction (fp) obtained from a heterogeneous multi-site
dataset showed software robustness and/or diagnostic utility, supporting their
potential consideration in controlled prospective trials. |
| 4764.
 | 126 | Renal MRI Assessment of the Effects of High-Water Intake on Total Kidney Volume Growth in ADPKD Hreedi Dev1, Chenglin Zhu1, Irina Barash2,3, Xinzi He1,4, Jon D. Blumenfeld2,3, and Martin R. Prince1,5
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Medicine, Weill Cornell Medicine, New York, NY, United States, 3The Rogosin Institute, New York, NY, United States, 4School of Electrical and Computer Engineering, Cornell University and Cornell Tech, New York, NY, United States, 5Radiology, Columbia College of Physicians and Surgeons, New York, NY, United States Keywords: Kidney, Kidney, ADPKD, CKD Motivation: By measuring height-adjusted total kidney volume (ht-TKV), renal MRI monitors autosomal dominant polycystic kidney disease (ADPKD) progression and evaluates therapeutic interventions’ efficacy for slowing cyst growth. Goal(s): Since arginine vasopressin (AVP) stimulates cyst growth, reducing vasopressin with high-water intake (HWI) may slow ADPKD progression. Approach: We test this hypothesis using a case-crossover study with 7 ADPKD subjects, measuring ht-TKV changes on MRI during usual and high-water intake. Results: High-water intake decreased 24-hour urine osmolality (359 vs 202mOsm/kg, p=0.002) and rate of increase in annualized ht-TKV growth rate (7.1% vs 3.5%, p=0.003), suggesting that high-water intake can slow ADPKD progression. Impact: Decreasing the rate of ht-TKV increase, measured by renal MRI during high water intake, suggests this as a potential treatment to slow progression of ADPKD, forestalling end-stage kidney failure requiring dialysis or transplantation. |
| 4765.
 | 127 | The diagnostic potential of magnetic resonance fluoroscopy in patients with achalasia Chao Wu1, Wei Zhao1, Chen Zhang2, and Haoran Sun1
1Tianjin Medical University General Hospital, Tianjin, China, 2Siemens Healthineers, Beijing, China Keywords: Digestive, Safety, magnetic resonance fluoroscopy;achalasia Motivation: A non-invasive imaging method, such as MR fluoroscopy, was used for treating achalasia patients. Goal(s): To determine whether MR fluoroscopy can diagnose patients with achalasia. Approach: We included 39 achalasia patients and 39 healthy volunteers. MR fluoroscopy was performed to observe the structure of the gastroesophageal junction. Results: We measured his angle, the esophageal width, the width of esophageal hiatus, the sphincter length, the angle between the lower esophagus and the longitudinal axis, and the angle between the lower esophageal sphincter and horizontal axis. The parameters of the patient group were statistically and significantly different from those of control group. Impact: MR fluoroscopy can be effectively used in the clinical
diagnosis of cardiac achalasia. The MR imaging method is a non-radiological
tool and is used to evaluate anatomical structures. |
| 4766.
 | 128 | The “MR Bra”: Development of a support device for supine breast imaging with commercially available flexible body coils Isobel Gordon1,2, Amy Herlihy2, Gemma Greenall2, Sally Collins1, and Michael Brady2,3
1Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom, 2Perspectum Ltd., Oxford, United Kingdom, 3Engineering Science, University of Oxford, Oxford, United Kingdom Keywords: Breast, Breast, Supine, support Motivation: Many women find conventional prone breast imaging uncomfortable. We developed a support device (the ‘MR Bra’) to enable supine breast imaging using existing flex coils, without breast compression. Goal(s): We aimed to evaluate the comfort of the MR bra and asses its SNR performance and structure visualisation capability. Approach: Two prototypes were developed. Healthy participants were scanned prone with the breast coil and supine using the flex coil and MR bra. The application of negative pressure was assessed with additional imaging. Results: The MR bra produced reduced, but acceptable, SNR values and improved patient comfort whilst enabling good visualisation of breast tissue structure. Impact: The MR bra enables comfortable supine breast imaging using readily-available flexible body coils whilst maintaining acceptable SNR values. Negative pressure to elongate the breast structure promises improved tissue visualisation. Further prototype development and evaluation of lesion identification is now underway. |