| Computer # |
| 3377.
 | 145 | Paeoniflorin's Cardioprotective Role in High-Altitude MI: A CMR Study Xin Fang1 and Fabao Gao1
1West China Hospital of Sichuan University, Chengdu, China Keywords: Heart Failure, Cardiovascular Motivation: To investigate the cardioprotective effects of paeoniflorin on myocardial infarction-induced ventricular remodeling in high-altitude hypobaric hypoxia environments. Goal(s): To evaluate the potential protective role of paeoniflorin in a rat model of myocardial infarction-induced ventricular remodeling under high-altitude hypobaric hypoxia using cardiovascular magnetic resonance strain analysis. Approach: Rats were allocated to plain sham operation control, high-altitude sham operation control, high-altitude myocardial infarction operation, and paeoniflorin treatment groups. CMR assessed cardiac function. Results: Paeoniflorin treatment groups demonstrated enhanced left ventricular function and regional strains compared to the myocardial infarction group. Histological analyses also showed reduced myocardial injury and fibrosis with paeoniflorin treatment. Impact: The
study's outcomes have implications for managing patients at risk of MI,
especially those in high-altitude environments or exposed to hypobaric hypoxia. |
| 3378.
 | 146 | Quantitative evaluation of carotid atherosclerotic characteristics using in vivo carotid MR imaging with MULTIPLEX Ran Huo1, Huiyu Qiao2, Shuo Chen3, Hualu Han3, Qiang Zhao4, Jiajia Xu4, Ying Liu4, Xihai Zhao2, and Huishu Yuan4
1Department of Radiology, Peking University Third Hospital, Beijing, China, 2Tsinghua University, Beijing, China, 3United Imaging Research Institute of Intelligent Imaging, Beijing, China, 4Peking University Third Hospital, Beijing, China Keywords: Atherosclerosis, Cardiovascular Motivation: Conventional carotid artery wall MR imaging is time-consuming due to multiple MR acquisitions. MULTIPLEX, a fast single-scan MRI technique, provides T1W/PDW/T2* maps simultaneously. Its potential in evaluating arterial plaque remains unexplored. Goal(s): Evaluating MULTIPLEX in characterising carotid plaque. Approach: We compared T1/PD/T2* values of arterial morphology and plaque components (lipid-rich necrotic core/intraplaque haemorrhage/loose matrix) in 33 participants using ANOVA between conventional technique and MULTIPLEX. Results: Significant T1/PD/T2* differences of plaque compositions mentioned above were found across all three groups with MULTIPLEX, similar to conventional technique. Varied plaque components displayed T1/PD/T2* differences. Impact: MULTIPLEX shows
promises in characterising arterial plaque beyond the brain. |
| 3379.
 | 147 | An Open-source, Flexible, Plug-and-Play Inline CMR Image Segmentation Platform Salah Assana1, Manuel A. Morales1, Jonah Castiglione1, Scott Johnson1, Patrick Pierce1, Jennifer Rodriguez1, Kelvin Chow2, Tess Wallace1,3, Pieter Kitslaar4, Warren J. Manning1,5, and Reza Nezafat1
1Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, United States, 2Cardiovascular MR R&D, Siemens Healthcare Ltd, Calgary, AB, Canada, 3Siemens Medical Solutions, Boston, MA, United States, 4Medis Medical Imaging Systems, Leiden, Netherlands, 5Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States Keywords: Heart Failure, Segmentation, Open-Source Motivation: Cardiac magnetic resonance (CMR) image segmentation remains a time-consuming task. Deep learning (DL) segmentation models have advanced considerably in recent years, but they lack flexibility for manual adjustments. Goal(s): We sought to develop an open-source, flexible plug-and-play inline CMR image segmentation platform. Approach: We implemented in-house algorithms in a clinical scanner as separate Python modules, allowing new and existing DL models to be integrated into clinical workflow. Results: We assessed the feasibility of the automated plug-and-play platform for inline cine segmentation in 308 patients referred for clinical CMR. Impact: This platform facilitates the rapid development and evaluation of any
segmentation algorithm in a transparent and reproducible fashion. An
open-source, flexible, plug-and-play inline CMR segmentation platform will
enable rapid testing and evaluation of new segmentation and analysis
algorithms. |
| 3380.
 | 148 | Analysis of postural effect on cardiac function using multiposture MRI Naoki Ohno1, Tosiaki Miyati1, Shoki Imao2, and Seiya Nakagawa3
1Kanazawa University, Kanazawa, Japan, 2Ogaki Municipal Hospital, Ogaki, Japan, 3Ishikawa Prefectural Central Hospital, Kanazawa, Japan Keywords: Myocardium, Heart, Cardiac function, Cine MRI, Multiposture MRI Motivation: Cardiac function is affected by body posture. However, MRI measurements have been limited to the supine posture. Goal(s): Our goal was to evaluate the effect of body posture on cardiac function using multiposture MRI. Approach: We assessed cardiac function in supine and standing postures in seven healthy males using a 0.4T multiposture MRI. Results: Significant reductions in left ventricular end-diastolic volume, end-systolic volume, and stroke volume were observed in the standing posture, with increased heart rate, while cardiac output and ejection fraction remained consistent across postures. Impact: Multiposture MRI enables the assessment of the postural effect on cardiac
function and potentially provides new diagnostic insights into regulatory response
to postural change. |
| 3381.
 | 149 | Feasibility of a 2D Radial Simultaneous Multi-Slice Phase Contrast MRI sequence for Aortic Pulse Wave Velocity Measurements Tarun Naren1, Grant S Roberts1, Kevin M Johnson1,2, Bri Breidenbach3, Mackenzie Jarchow3, Sarah Lose3, Alyssa Pandos3, Ozioma Okonkwo3, and Oliver Wieben1,2
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Medicine, University of Wisconsin-Madison, Madison, WI, United States Keywords: Flow, Velocity & Flow, Simultaneous Multi-Slice, Pulse Wave Velocity Motivation: Pulse wave velocity (PWV) is an important biomarker for cardiovascular risk that can be measured non-invasively with phase contrast MRI. Sequential scans at different planes can lead to inaccurate measurements so an alternate approach is needed.
Goal(s): We aim to develop a 2D simultaneous multi-slice (SMS) radial phase contrast sequence to image multiple planes concurrently, reduce timing inconsistencies, and measure PWV more accurately.
Approach: The radial phase contrast SMS sequence was implemented on a GE scanner and included in an ongoing volunteer study.
Results: The SMS scan provided higher quality images in less scan time than sequential and had reduced timing inconsistencies.
Impact: Pulse wave velocity (PWV) is a
clinically important biomarker for cardiovascular risk. A simultaneous
multi-slice radial 2DPC sequence allows for faster, more accurate MR flow
measurements with high temporal resolution and reduced timing inconsistency which
can improve early detection. |
| 3382.
 | 150 | A Spiral, Golden Angle SPGR Sequence for Blood Vessel T1 and T2 Measurement Troy Umolac1,2, Sharon Portnoy2, Liqun Sun2,3, Mike Seed2,3,4, and Christopher K. Macgowan1,2
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, 3Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, 4Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada Keywords: Vascular, Blood Motivation: Current methods for measuring T1 and T2 in fetal blood are inefficient, which limits their applicability to the largest vessels in late gestation. Goal(s): To develop a faster, more motion-robust sequence for blood T1 and T2 measurement, which can be applied in fetal subjects. Approach: A spiral, spoiled gradient echo sequence (sp-SPGR) was developed to jointly estimate blood T1 and T2 from a single, 12 second scan. sp-SPGR accuracy was validated in adult volunteers by comparison with conventional MOLLI and T2p-bSSFP techniques. Results: The sp-SPGR sequence obtained T1 and T2 estimates consistent with conventional methods in approximately one-fifth the acquisition time. Impact: As a faster, more motion robust sequence for estimating blood T1 and T2, sp-SPGR will support oximetry measurements in the fetal great vessels at earlier gestational age, facilitating more accurate and timely evaluation of fetal hypoxia. |
| 3383.
 | 151 | Monitoring relative diameter change of the carotid artery using non-contrast-enhanced 4D dynamic angiography: preliminary results Isabel Montón Quesada1, Augustin C. Ogier1, Robin Ferincz1, Jean-Baptiste Ledoux1,2, Aurélien Bustin1,3,4, Patrik Michel5, Jérôme Yerly1,2, Matthias Stuber1,2, Christopher W. Roy1, and Ruud B. van Heeswijk1
1Department of Radiology, Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2CIBM Center for BioMedical Imaging, Lausanne, Switzerland, 3IHU LIRYC, Electrophysiology and Heart Modeling Institute, INSERM U1045, Centre de recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux, France, 4Department of Cardiovascular Imaging, Hôpital Cardiologique du Haut-Lévêque, CHU de Bordeaux, Bordeaux, France, 5Stroke Center, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland Keywords: Vascular, Blood vessels, Carotid Diameter, Pulsatile Motion, Angiography Motivation: The carotid artery anatomy is routinely studied with MRI, whilst its relative diameter change is evaluated using ultrasound. An MRI technique to measure the carotid diameter change throughout the cardiac cycle could therefore be complementary to the existing toolset. Goal(s): To combine carotid MR angiography and diameter change quantification in one scan without contrast agent injection. Approach: A 4D (3D+time) free-running sequence was extended with slab-selective RF pulses to increase the inflow blood-to-muscle contrast. Carotid diameter changes and contrast ratios were quantified. Results: The contrast ratio significantly improved with the use of slab-selective pulses and the carotid relative diameter change was precisely measured. Impact: 4D free-running MR
angiography with slab-selective RF pulses allows for the dynamic visualization
of the carotid lumen and the quantification of the relative carotid diameter
change throughout the cardiac cycle without contrast agent injection. |
| 3384.
 | 152 | The Value of Multimodal Atherosclerotic Plaque Imaging Coordinated Analysis in the Assessment of Cardiovascular and Cerebrovascular Events Yonghong Zheng1,2, Shun Yu1,2, Xiaomin Dai1,2, Huangjing Chen1,2, Shengsheng Yang1,2, Mingping Ma1,2, Feng Huang2,3, Pengli Zhu2,3, and Yang Song4
1Radiology department, Fujian Provincial Hospital, Fuzhou, China, 2Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China, 3Department of Geriatric Medicine, Fujian Provincial Hospital, Fuzhou, China, 4MR Research Collaboration Team, Siemens Healthineers Ltd., Shanghai, China Keywords: Vessel Wall, Atherosclerosis, intracranial artery, stroke, coronary artery Motivation: The coexistence of atherosclerosis in coronary, and intracranial arteries has not been comprehensively assessed. Goal(s): This study was designed to investigate the co-existence of atherosclerosis in the intracranial and coronary arteries of patients with and without ASCVD using high-resolution magnetic resonance imaging and computed tomography angiography. Approach: The ASCVD group exhibited greater artery stenosis, as well as significant differences in lipid, calcium volumes, and lipid volume ratio compared to the non-event group. Additionally, different plaque types displayed significant variations in morphology and composition. Results: There is a consistent pattern of change in plaque characteristics between intracranial and coronary arteries. Impact: High-resolution magnetitic resonance imaging (hrMRI) and coronary computed tomography angiography (CCTA) to investigate the co-existence of high-risk atherosclerotic plaques in the intracranial and coronary arteries of patients with cardiovascular events. Results showed that such plaques were present in both locations. |
| 3385.
 | 153 | Fibrous cap status, plaque surface morphology, and intraplaque hemorrhage volume over two years in patients with carotid plaques: PARISK study Mohamed Kassem1,2, Tahnee Gorissen2, Mohammad Albenwan2, Dianne H.K. van Dam-Nolen3, Madieke I Liem4, Paul AM Hofman2, Joachim E E Wilberger1,2, Jeroen Hendrikse5, Werner Mess6, Paul J J Nederkoorn4, Daniel Bos3,7, Patty Nelemans8, Robert J. van Oostenbrugge1,9, and M Eline Kooi1,2
1Cardiovascular Research Institute Maastricht (CARIM), MAASTRICHT, Netherlands, 2Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, MAASTRICHT, Netherlands, 3Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, 4Department of Neurology, Amsterdam UMC, location AMC, Amsterdam, Netherlands, 5Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 6Department of Clinical Neurophysiology, Maastricht University Medical Center, maastricht, Netherlands, 7Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, 8Department of Epidemiology, Maastricht University, maastricht, Netherlands, 9Department of Neurology, Maastricht University Medical Center, MAASTRICHT, Netherlands Keywords: Atherosclerosis, Atherosclerosis, Carotid, Stroke Motivation: We explored the relationship between intraplaque hemorrhage (IPH) and thin/ruptured fibrous cap (TRFC) or disrupted plaque surface. Goal(s): We investigated the relationship between a TRFC/disrupted plaque surface and the change in carotid IPH volume Approach: Longitudinal carotid MR study in 110 symptomatic patients with mild-to-moderate carotid stenosis. Results: Baseline MR images revealed a larger IPH volume in patients with a TRFC/disrupted plaque surface and the IPH volume (tended to) decrease during follow-up. However, part of patients with a TRFC/disrupted plaque surface at baseline had a higher risk of IPH progression. Impact: Identifying patients at higher risk of IPH
progression allows for timely monitoring and intervention, potentially reducing
the incidence of stroke. This research contributes to improved quality of life
for individuals at risk of carotid IPH-related complications |
| 3386.
 | 154 | RAMI: Radiomics Predictive Model of Myocardial Infarction and Microvascular Obstruction Joao Santinha1 and Teresa M Correia2,3
1Champalimaud Foundation, Lisbon, Portugal, 2Center of Marine Sciences (CCMAR), Faro, Portugal, 3School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom Keywords: Myocardium, Radiomics, Late Gadolinium Enhancement; Myocardial Infarction; Microvascular Obstruction; Random Forest; Motivation: Late gadolinium Enhancement (LGE) is the method of choice for assessing myocardial infarction (MI) and viability, essential to guide revascularization decisions. LGE also shows no-reflow regions that occur when blood flow remains inadequate post-revascularization. Existing automatic segmentation methods identify regions of LGE uptake but ignore no-reflow regions. Goal(s): Our goal is to provide a robust and automated solution for the detection of MI and no-reflow. Approach: We propose two LGE-based radiomics models, RAMI and RAMI-NOR, to improve MI diagnosis and detect no-reflow, respectively. Results: RAMI distinguishes normal and pathological cases accurately. RAMI-NOR shows potential in assessing MI with no-reflow but needs further refinement. Impact: The proposed RAMI
and RAMI-NOR methods extract radiomics features from LGE images to
automatically detect infarcted and microvascular obstruction areas, essential
for the diagnosis and treatment
management of patients suffering from myocardial infarction. |
| 3387.
 | 155 | The combination of carotid plaques characteristics and white matter lesions burden may predict ischemic stroke severity in symptomatic patients Zhimeng Cui1 and Jun Zhang1
1Department of Radiology, Huashan Hospital, Fudan University, shanghai, China Keywords: Atherosclerosis, Atherosclerosis Motivation: Acute care decisions, such as the initiation of anticoagulant therapy, are affected by infarction degree. Goal(s): To assess the severity of ischemic stroke and prognosis in patients with symptomatic carotid artery stenosis, this study combined cerebral WMLs burden derived from FLAIR and carotid plaque characteristics based on HRVW-MRI to construct a noninvasive model. Approach: Logistic regression analysis and LASSO regression analysis were utilized to develop predictive nomogram model. Results: The AUC of predictive model was 0.92 in the training and 0.88 in the validation cohort, and showed good clinical utility. The hybrid model-derived score was an independent predictor of mRS score. Impact: The high discriminative ability indicates the potential of this model for classifying patients with nervous functional defect according to NIHSS score.The hybrid model-derived score is related to judge the neurological function recovery. |
| 3388.
 | 156 | Automatic Carotid Plaque Segmentation Using Deep Learning Model with Multi-Head Loss Integrating Anatomical Features Long Yang1, Jinhua Dong2, Xiong Yang2, Yufei Mao2, Guanxun Cheng3, Ye Li1,4,5, Dong Liang1,4,5, Xin Liu1,4,5, Hairong Zheng1,4,5, and Na Zhang1,4,5
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shen Zhen, China, 2Department of Image Advanced Analysis of HSW BU, Shanghai United Imaging Healthcare Co., Ltd., Shanghai, China, 3Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, China, 4Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, Shenzhen, China, 5United Imaging Research Institute of Innovative Medical Equipment, Shenzhen, China Keywords: Vessel Wall, Stroke Motivation: With the assistance of prior vessel wall mask, segmentation of atherosclerotic plaque can achieve satisfactory performance. However, manual sketching of vessel wall mask is still time-consuming. Goal(s): To propose a method for fast and accurate plaque segmentation without relying on prior knowledge of vessel walls. Approach: This study proposes a deep learning model based on a multi-head loss design for automatic segmentation of carotid artery plaques, with the aim of reducing dependence on prior information of vessel walls in plaque segmentation. Results: In the independent test, the model with the multi-head loss design achieving excellent results similar to using vessel wall prior. Impact: This study achieved fully automatic and accurate plaque segmentation without manual priors, which will greatly reduce burden of radiologist to segment and quantify plaque, and also contribute to more efficient stroke risk assessment, progress monitoring, and efficacy evaluation for patient. |
| 3389.
 | 157 | PCASL with a clinically practical ischemia-hyperemia protocol for use in critical limb threatening ischemia Conrad von Stempel 1, Timothy JP Bray2, Alex Kirkham3, Janice Tsui4, and Magdalena Sokolska5
1Imaging, University College London, London, United Kingdom, 2Centre for Medical Imaging, University College London, London, United Kingdom, 3Imaging, University College London Hospital, London, United Kingdom, 4Vascular Surgery, University College London, London, United Kingdom, 5Medical Physics and biomedical engineering, University College London Hospital, London, United Kingdom Keywords: Vascular, Arterial spin labelling Motivation: Lower-limb vascular imaging used in advanced peripheral arterial disease PAD) is limited to luminography with no functional tissue perfusion data. Goal(s): MRI ASL perfusion quantification is a contrast agent free technique that promises to be a novel imaging biomarker for tissue viability. However, current implementations have several limitations, including low signal-to-noise and the need for a substantial period of hyperemia to induce measurable perfusion in the muscle. Approach: We aimed to develop an abbreviated, clinically-practical ischemia-hyperemia paradigm to measure perfusion, and to evaluate this in volunteers. Results: A 2-minute period of ischemia produced hyperemia a doubling of baseline perfusion, sustained for 30 seconds. Impact: Quantitative perfusion imaging with pseudocontinuous arterial spin labelling can be achieved in the lower limb with an ischemia-hyperemia paradigm with 2 minutes of ischemia. This clinically applicable technique can be used in the assessment of peripheral arterial disease. |
| 3390.
 | 158 | Signal intensity and volume of carotid intraplaque hemorrhage on MRI and ipsilateral cerebrovascular events: the Plaque At RISK (PARISK) study Kelly P.H. Nies1,2, Mueez Aizaz1,2, Dianne H.K. van Dam-Nolen3,4, Timothy C.D. Goring5, Tobien A.H.C.M.L. Schreuder6, Narender P. van Orshoven7, Alida A. Postma1,8, Daniel Bos3,9, Jeroen Hendrikse10, Paul Nederkoorn5, Rob van der Geest11, Robert J. van Oostenbrugge2,12, Werner H. Mess2,13, and M. Eline Kooi1,2
1Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, Netherlands, 2Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands, 3Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, Netherlands, 4Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands, 5Department of Neurology, Amsterdam University Medical Center, Amsterdam, Netherlands, 6Department of Neurology, Zuyderland Medical Center, Heerlen, Netherlands, 7Department of Neurology, Zuyderland Medical Center, Sittard, Netherlands, 8School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, Netherlands, 9Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands, 10Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, Netherlands, 11Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 12Department of Neurology, Maastricht University Medical Centre, Maastricht, Netherlands, 13Department of Clinical Neurophysiology, Maastricht University Medical Centre, Maastricht, Netherlands Keywords: Atherosclerosis, Stroke Motivation: The presence of intraplaque hemorrhage (IPH) is a strong independent stroke predictor. Higher IPH signal intensity ratios (SIR) and volumes were found in symptomatic versus asymptomatic carotid arteries. Goal(s): To determine if IPH SIR and volume are associated with the risk for ipsilateral ischemic neurovascular events in symptomatic patients with <70% carotid stenosis. Approach: Cox proportional hazards and logistic regression were used to explore the association of IPH SIR and volume to ipsilateral ischemic neurovascular events in 87 IPH-positive patients. Results: IPH SIR and IPH volume were not associated with risk for ipsilateral ischemic events during 5.1(IQR:3.1-5.6) years. Impact: No association was found between IPH
SIR or volume and the risk for ipsilateral ischemic neurovascular events or new
infarcts on brain MRI. Therefore, identifying the presence of IPH is sufficient
for risk stratification. |
| 3391.
 | 159 | CMR-based estimation of mean pulmonary arterial pressure and pulmonary vascular resistance in CTD-PAH Kefan Ma1, Yidan Zhu1, Wangyan Liu1, Xiaomei Zhu1, Qiang Wang2, Xiaoxuan Sun2, Yinsu Zhu3, and Yi Xu1
1Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 2Department of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3Department of Radiology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China Keywords: Vascular, Cardiovascular Motivation: This research explores the potential of cardiac magnetic resonance (CMR) as a noninvasive tool for evaluating pulmonary arterial hypertension (PAH) in connective tissue disease-associated PAH (CTD-PAH) patients. Goal(s): The goal is to estimate mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR) accurately using CMR metrics, with right heart catheterization (RHC) as the gold standard. Approach: Correlations between CMR and RHC parameters were assessed, and predictive models for mPAP and PVR were developed. Results: Strong correlations were observed between RHC and CMR metrics. Predictive CMR models were established for both mPAP and PVR, offering potential clinical applications. Impact: CMR parameters can be used to estimate mPAP and PVR in patients with CTD-PAH, potentially providing a noninvasive method for assessing pulmonary arterial hemodynamics during CTD-PAH management. |