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| 3060.
 | 145 | Brain consciousness affects HP lactate labeling from HP pyruvate Thanh Phong Lê1, Andrea Capozzi1,2, Jean-Noël Hyacinthe1, and Mor Mishkovsky1
1Laboratory of Functional and Metabolic Imaging, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Department of Health Technology, Center for Hyperpolarization in Magnetic Resonance, Technical University of Denmark, Kgs Lyngby, Denmark Keywords: Hyperpolarized MR (Non-Gas), Brain, Anesthesia, anaesthesia, cerebral, mouse, pyruvate, lactate, hyperpolarized, hyperpolarization, DNP, metabolism, metabolic Motivation: Brain metabolism and activity are closely related. General anesthesia, commonly used in preclinical studies, alters functional connectivity, hemodynamics and metabolism. In preclinical MR, metabolic studies frequently employ isoflurane, while a medetomidine-isoflurane combination is preferred for fMRI. Detection of HP substrate conversions is the sole MR technology capable to capture real-time metabolism. Goal(s): Towards rodent fMRSI studies, we aim to compare the cerebral metabolism of HP [1-13C] pyruvate between mice under isoflurane-only and combined medetomidine-isoflurane anesthesia. Approach: Dynamic MRSI at high spatiotemporal resolution characterized HP pyruvate metabolism. Results: Pyruvate-to-lactate turnover is lower and delayed under medetomidine-isoflurane compared to isoflurane-only anesthesia. Impact: Anesthesia can modulate brain consciousness. Significantly higher hyperpolarized pyruvate-to-lactate turnover is observed in mice under isoflurane-only compared to medetomidine-isoflurane anesthesia. Beyond this finding’s relevance for preclinical studies, this opens opportunities for probing brain biochemistry in patients under general anesthesia.
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| 3061.
 | 146 | Molecular Profiling Distinguishes HCC Metabotypes Identified on Hyperpolarized 1-13C Pyruvate Magnetic Resonance Spectroscopy Bukola Yetunde Adebesin1, David Tischfield2, Ariful Islam2, Molly Sheehan2, Alexander I Zavriyev3, Aayush Bendre4, Daniel Ackerman2, Stephen Kadlecek2, and Terence Gade5
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 4Department of Chemical Engineering, University of Pennsylvania, Philadelphia, PA, United States, 5Department of Radiology. Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA, United States Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), Hepatocellular Carcinoma, Kinetic Modeling Motivation: While hyperpolarized 1-13C Pyruvate Magnetic Resonance Spectroscopy holds great promise for in vivo profiling of cellular metabolism, the molecular alterations underlying the observed metabolic phenotypes (metabotypes) remain understudied. Goal(s): We sought to characterize the molecular features contributing to the metabotypes identified on Hyperpolarized 1-13C Pyruvate MRS in hepatocellular carcinoma (HCC). Approach: We integrated transcriptomic and proteomic profiling together with hyperpolarized 1-13C Pyruvate MRS of HCC patient-derived xenografts (PDX) that recapitulate the diversity of gene and protein expression observed in patients. Results: Our data suggest that hyperpolarized 1-13C Pyruvate MRS distinguishes HCC metabotypes based on MCT4 expression. Impact: By
applying clinically relevant PDX models of HCC harboring naturally occurring
variability in expression of metabolic enzymes and transporters, our data
provide critical insights into the interpretation of hyperpolarized 1-13C
Pyruvate MRS during clinical translation. |
| 3062.
 | 147 | A data-driven approach for improved quantification of in-vivo metabolic conversion rate of hyperpolarized [1-13C]pyruvate Yaewon Kim1, Tanner Nickles1, Philip M. Lee1, Robert A. Bok1, Jeremy W. Gordon1, Peder E. Z. Larson1, Daniel B. Vigneron1,2, and Michael A. Ohliger1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States, 2Department of Neurological Surgery, University of California, San Francisco, CA, United States Keywords: Data Processing, Hyperpolarized MR (Non-Gas) Motivation: Accurate quantification of metabolism in hyperpolarized (HP) 13C MRI is essential for clinical application. However, kinetic model parameters such as flip angle are often uncertain, leading to model mismatch. Goal(s): We aimed to develop a data-driven approach to quantify the HP pyruvate-to-lactate conversion rate (kPL) for with improved accuracy. Approach: To validate our method, we conducted numerical simulations and animal studies with HP 13C-pyruvate and applied this method to human abdominal data. Results: Our findings revealed that the data-driven kinetic fitting method can improve model-data fits by correcting flip angle and relaxation errors, resulting in more accurate kPL determination. Impact: Using the new data-driven kinetic fitting method to quantify HP 13C-pyruvate metabolism, accurate kPL can be obtained even in the presence of B1 inhomogeneity. This improvement may prove to be clinically valuable in improving tumor staging or assessing treatment-response. |
| 3063.
 | 148 | Spatially Constrained Estimation of Hyperpolarized 13C MRI Pharmacokinetic Rate Constant Maps using a U-Net Sule Sahin1,2, Zhen Jane Wang1, and Peder E.Z. Larson1,2
1Radiology, University of California, San Francisco, San Francisco, CA, United States, 2UC Berkeley - UCSF Graduate Program in Bioengineering, Berkeley, CA, United States Keywords: Hyperpolarized MR (Non-Gas), Simulations Motivation: Current kPL fitting methods for Hyperpolarized [1-13C]Pyruvate MRI data are focused on voxel-wise models that do not consider spatial relationships. Incorporating spatial constraints may improve kPL accuracy for noisy data. Goal(s): The goal of this study was to use a U-net to fit kPL, the pyruvate-to-lactate conversion rate, where the convolutional layers impose spatial constraints. Approach: Simulated data of Hyperpolarized 13C-Pyruvate including perfusion and 13C-lactate conversion with random spatial augmentation and noise was used to train a U-net. Results: The U-net kPL estimation showed advantage over voxel-wise methods in the low SNR regime and performance was heavily influenced by the training data. Impact: Using a U-Net to estimate kPL maps for Hyperpolarized 13C-Pyruvate MRI data will aid the field in optimizing quantitative methods for future clinical use and serve as a proof-of-concept of using deep learning to estimate kinetic rates. |
| 3064.
 | 149 | Implementing fully endogenous hyperpolarized molecular probes for imaging cerebral metabolism Fatemeh Anvarivind1, Thanh Phong Lê1, Andrea Capozzi1,2, and Mor Mishkovsky1
1LIFMET, EPFL, Lausanne, Switzerland, 2Health technology department, DTU, Kgs Lyngby, Denmark Keywords: Hyperpolarized MR (Non-Gas), Brain Motivation: Photo-induced non-persistent radicals for dissolution Dynamic Nuclear Polarization (dDNP) reduce the delay between the preparation and injection of hyperpolarized (HP) substrates by avoiding the need for filtering potentially toxic radicals. Goal(s): Our goal was the in vivo implementation of probes hyperpolarized with endogenous non-persistent polarizing agents. Approach: Brain metabolism of HP glucose was monitored in a group of 12h-fasted male mice. Results: The lactate-to-glucose ratio (LGR) was found similar to previously reported values, with a trend of higher LGR when glucose was hyperpolarized with alpha-ketoglutarate (aKG) than Trityl radicals.
Impact: Our investigation demonstrates the successful in-vivo application of
radical-free HP glucose, revealing metabolic responses comparable to those
achieved with stable persistent radicals and indicating the potential benefits
of hyperpolarizing glucose with aKG radicals. |
| 3065.
 | 150 | Fast repeated administrations of PHIP hyperpolarized [1-13C]pyruvate enables averaging of in vivo metabolism in a single MRI exam Christoph A. Müller1, Luca Nagel2, Martin Gierse 1, Wolfgang Gottwald2, Zumrud Ahmadova1, Martin Grashei2, Pascal Wolff1, Felix Josten1, Senay Karaali1, Sebastian Lucas1, Jochen Scheuer1, Christoph Müller1, John Blanchard1, Geoffrey J. Topping2, Andre Wendlinger2, Nadine Setzer2, Sandra Sühnel2, Jonas Handwerker1, Christopheros Vassiliou1, Frits H.A. van Heijster2, Stephan Knecht1, Michael Keim1, Franz Schilling2, and Ilai Schwartz1
1NVision Imaging Technologies GmbH, Ulm, Germany, 2Department of Nuclear Medicine, TUM School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas) Motivation: Parahydrogen Induced Polarization (PHIP) is a potential alternative to d-DNP for the polarization of [1-13C]pyruvate, but has so far been limited to low polarizations, low concentrations, and high impurities. Goal(s): We present, for the first time at a conference, recent advances in the polarization of [1-13C]pyruvate using PHIP via Side-Arm-Hydrogenation. Approach: Demonstration of an automated production of hyperpolarized [1-13C]pyruvate using PHIP-SAH. The PHIP system was benchmarked against a d-DNP system and hyperpolarized [1-13C]pyruvate from both systems was injected in animals for comparative in vivo metabolic MRI. Results: PHIP and d-DNP based hyperpolarization achieve comparable results, but PHIP is much faster. Impact: PHIP is demonstrated as a fast, effective, and cost-efficient polarization method for [1-13C]pyruvate. With very short dose production times, researchers are enabled to administer multiple (4) injections into the same animal within reasonable anesthesia time (<1h), allowing averaging of metabolism. |
| 3066.
 | 151 | Portable polarizer for clinical-scale metabolic MRI of hyperpolarized pyruvate Sergey Korchak1,2, Jan Felger1,2, Denis Moll1,2, Henning Schroeder1,2, and Stefan Glöggler1,2
1Max Planck Institute for Multidisciplinary Sciences, Goettingen, Germany, 2Center for Biostructural Imaging of Neurodegeneration, Goettingen, Germany Keywords: Hyperpolarized MR (Non-Gas), Cancer, clinical application Motivation: The limited availability and accessibility of cost-effective quantities of 13C-hyperpolarized metabolites, such as pyruvate, acts as a significant barrier to the advancement and practical clinical implementation of metabolic-driven molecular imaging, especially in early-stage cancer detection. Goal(s): Objective is to develop a portable device capable of delivering sufficient, clinically relevant doses of hyperpolarized pyruvate to support medical applications. Approach: We employ the Parahydrogen-Induced Polarization with Side Arm Hydrogenation approach, which offers a faster (~1min) and more cost-efficient alternative to the prevailing state-of-the-art technology, dissolution Dynamic Nuclear Polarization. Results: Our polarizer routinely produces a 40ml dose of hyperpolarized 13C-pyruvate-d3, containing a concentration exceeding 100mM. Impact: Enhancing accessibility to clinically relevant hyperpolarized pyruvate will empower more MR research groups to leverage its potential. This development also paves the way for easier translation to clinical settings, ultimately benefiting cancer patients by supporting early detection and diagnosis capabilities. |
| 3067.
 | 152 | Hyperpolarized 13C metabolic imaging of Alzheimer’s Disease: impact of sex, genotype and age in the hAPP-J20 mouse model Marina Radoul1,2, Lydia M. Le Page1,2, Caroline Guglielmetti1,2, Huihui Li3, Ken Nakamura3,4, and Myriam M. Chaumeil1,2
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, United States, 3Gladstone Institute of Neurological Disease. Gladstone Institutes, San Francisco, CA, United States, 4Department of Neurology, University of California San Francisco, San Francisco, CA, United States Keywords: Hyperpolarized MR (Non-Gas), Alzheimer's Disease, metabolism, hyperpolarized 13C Motivation: The accelerating prevalence of Alzheimer's disease (AD) around the world urges the need not only for more effective treatment but also for improved non-invasive monitoring of onset and progression. Goal(s): Our goal is to investigate if the clinically expanding HP 13C MR method could improve diagnosis and monitoring of AD. Approach: hAPP-J20 AD mice and age-/sex-matched wild-type were imaged using HP 13C MR at 2-months-old (presymptomatic) and 14-months-old (amyloid plaques accumulation). The impact of sex, genotype, age, and their interactions, on the derived HP metrics was investigated. Results: HP13C metabolic imaging can provide crucial information on sexual dimorphism and metabolic aging in AD. Impact: Hyperpolarized 13C imaging provides unique metabolic information specific to sex and APP mutational status in an AD model. Upon clinical translation, such method could improve early diagnosis and patient-centric monitoring of AD progression, and potentially assessment of therapeutic response. |
| 3068.
 | 153 | Comparison of Hyperpolarized 13C Pyruvate MRI and 1H MRI for Predicting Renal Tumor Aggressiveness Xiaoxi Liu1, Shuyu Tang2, Allison Sabb3, Di Cui1, Adam Olshen4, Jeremy W. Gordon1, Maxwell V. Meng5, Peder E.Z. Larson1,6, and Zhen J. Wang1
1Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Vista.ai Inc., Los Altos, CA, United States, 3Life Sciences Institute, University of Michigan, Ann Arbor, MI, United States, 4Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, United States, 5Department of Urology, University of California San Francisco, San Francisco, CA, United States, 6Graduate Program in Bioengineering, University of California, Berkeley and San Francisco, San Francisco, CA, United States Keywords: Hyperpolarized MR (Non-Gas), Cancer Motivation: Current imaging methods have limitations in predicting localized renal tumor aggressiveness. Goal(s): Comparing the performance of predicting high grade ccRCCs, typically considering as aggressive RCCs, by different MR imaging methods. Approach: We compared the performance of hyperpolarized 13C pyruvate MRI and 1H MRI for predicting high-grade ccRCCs in 22 localized renal tumors. Results: Hyperpolarized 13C-labelled lactate-to-pyruvate ratio was significantly higher in high-grade ccRCCs compared to other renal tumor group(benign renal tumors, chromophobe RCCs, and low grade ccRCCs, P=0.003). Neither the percentage signal intensity change from contrast-enhanced MRI nor the apparent diffusion coefficient from diffusion-weighted MRI was able to differentiate between the two groups. Impact: Compared to 1H MRI, HP 13C MRI enables improved prediction of high-grade clear cell renal cell carcinomas. |
| 3069.
 | 154 | Assessing Pre-Treatment Metabolic Profiles in High-Risk DLBCL via Hyperpolarized 13C-Pyruvate MR Spectroscopy Ying-Chieh Lai1,2, Ching-Yi Hsieh1,3, Kuan-Ying Lu2, Hsien-Ju Lee1, Wen-Yen Chai2, Gigin Lin1,2, and Yu-Hsiang Juan2
1Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, 2Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, 3Research Center for Radiation Medicine, Chang Gung University, Taoyuan, Taiwan Keywords: Hyperpolarized MR (Non-Gas), Metabolism Motivation: The study addresses the need for early detection of treatment response in high-risk diffuse large B cell lymphoma, where traditional methods based on tumor size are inadequate. Goal(s): The study aims to validate 13C-Pyruvate DNP MR spectroscopy as a sensitive technique for early evaluation of treatment efficacy in lymphoma patients. Approach: Utilizing 13C MRS, the research monitors the metabolic conversion of 13C-labeled pyruvate to lactate, reflecting the treatment's impact on the tumor's metabolic activity. Results: Preliminary data from three patients show different metabolic rates, indicating the potential of this method to discern early treatment responses, leading to more timely and effective clinical decisions. Impact: These results could revolutionize protocols for lymphoma
by enabling earlier assessment of therapy efficacy, thus informing more
timely adjustments to treatment strategies. This advancement may spur
further metabolic research and ultimately improving survival rates and quality of life for patients. |
| 3070.
 | 155 | Repeatability of Hyperpolarized [1-13C]pyruvate MRI Cardiac Metabolism Measurements in Humans Avantika Sinha1, Anna Bennett1, Xiaoxi Liu1, Robert Bok1, Jeremy W Gordon1, Roselle M Abraham2, and Peder Eric Zufall Larson1
1Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States, 2Medicine - Cardiology, University of California - San Francisco, San Francisco, CA, United States Keywords: Hyperpolarized MR (Non-Gas), Metabolism Motivation: Hyperpolarized (HP) 13C-pyruvate MRI is an emerging tool with the potential to provide unprecedented measurements of cardiac metabolism. Goal(s): The goal of this work was to measure the repeatability of HP 13C-pyruvate, which is important for designing clinical trials and identifying opportunities to improve the technique. Approach: Two HP 13C-pyruvate scans were performed in a single session approximately 15 minutes apart in healthy volunteers who were in the fed state. Results: We measured no statistically significant differences between scans and measured the coefficient of variance of metabolism quantifications using pharmacokinetic rate constants. Blood glucose changed between scans and can affect the metabolism measurements. Impact: These assessments of repeatability of Hyperpolarized 13C-pyruvate MRI in the human heart will support the design of clinical trials and also guide where potential improvements are required to improve measurements of metabolism. |
| 3071.
 | 156 | Task Activation of Human Occipital Lobe Results in Hyperpolarized 13C-Lactate Signal Increase Biranavan Uthayakumar1,2, Nicole I.C. Cappelletto1,2, Nadia D Bragagnolo2, Hany Soliman3, Albert P Chen4, Nathan Ma5, Fred Tam2, William J Perks5, Ruby Endre2, Simon J Graham1,2, Kayvan R Keshari6, and Charles H Cunningham1,2
1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4GE Healthcare, Toronto, ON, Canada, 5Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 6Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York City, NY, United States Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas) Motivation: Increases in lactate production are believed to occur in occipital lobe regions in response to visual stimuli. Goal(s): In this study, whole-brain hyperpolarized-13C MRI was used to investigate how a visual stimulus affects occipital lobe 13C-lactate signal in healthy human volunteers. Approach: A set of two hyperpolarized-13C MRI scans were done. Participants (n = 6) viewed a flashing checkerboard stimulus during one of the 13C scans, and had their eyes closed for the second 13C scan. Results: Increased 13C-lactate signal was observed in the visual stimulus scans when compared to the eyes-closed scans in occipital lobe regions relative to non-occipital lobe regions. Impact: We have shown that hyperpolarized-13C MRI is capable of measuring differences in 13C-lactate signal in response to a visual stimuli. These findings support the idea of increases in lactate production in response to stimulus. Future studies will explore other stimuli. |
| 3072.
 | 157 | Optimal, AUC-Derived Coil Combination Coefficients for Hyperpolarized 13C Imaging Qing Wang1, Christopher M. Walker1, Collin J. Harlan1,2, Ryan T. Boyce1,3, Cade P. Sony1,4, Stephen Y. Lai5, and James A. Bankson1
1Imaging Physics, The University of Texas MD Anderson Cancer Center, Houton, TX, United States, 2The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United States, 3Physics, University of Houston, Houston, TX, United States, 4Electrical Engineering, University of Houston, Houton, TX, United States, 5Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houton, TX, United States Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), Coil combination, 13C, Pyruvate, optimal combination coefficients Motivation: B1-maps that are used for optimal combination in array coils are generally unavailable for hyperpolarized (HP) MRI. Alternative methods for determining optimal combination coefficients are needed. Goal(s): To show that optimal combination coefficients can be derived from area-under-the-curve (AUC) and noise measurements to maximize SNR in HP MR imaging and spectroscopy. Approach: We derive combination coefficients from AUC and noise covariance measurements, simulate noisy HP 13C-pyruvate and 13C-lactate signals, and analyze the SNR of combined signals using this method compared to sum-of-squares (SoS) combination. Results: Simulated 13C HP signals that were combined using this approach demonstrated higher SNR compared to the SoS method. Impact: The optimal combination coefficients for HP 13C in MR imaging
and spectroscopy can be derived from AUC and noise covariance measurements.
This straightforward method can enhance SNR for HP 13C MRI. |
| 3073.
 | 158 | Hyperpolarized 13C Metabolic Imaging in Human Subjects with Advanced Coronary Artery Disease: Initial Experience and Thoughts Gaurav Sharma1,2, Sarah McNeil1, Sung-Han Lin2, Crystal Harrison2, Jae Mo Park2, Matthias Peltz1, Craig R. Malloy2,3,4, and Michael E. Jessen1
1Cardiovascular and Thoracic Surgery, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 4Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), Coronary Artery Disease, FDG PET-CT, Ischemic Heart Disease Motivation: Coronary Artery Disease (CAD) continues to be a significant health issue worldwide, necessitating enhanced diagnostic methods capable of imaging cardiac metabolism. Hyperpolarized Carbon-13 Magnetic Resonance Imaging (HP-13C MRI) offers a potential solution for the non-invasive evaluation of metabolism in the human heart. Goal(s): Our goal is to demonstrate the feasibility of HP-13C MRI in two human subjects with advanced CAD. Approach: By examining these subjects, we have successfully imaged metabolic abnormalities within the myocardium. Results: Our results indicate promising potential for using this technology to visualize dynamic changes in cardiac energetics associated with CAD. These findings can potentially influence the management of CAD. Impact: This study establishes HP 13C-MRI as a safe, non-invasive tool for visualizing metabolic abnormalities in CAD patients, paving the way for more precise management of ischemic heart disease and prompting further comparative research with traditional imaging methods. |
| 3074.
 | 159 | Coronary angiography and myocardial perfusion MRI using hyperpolarized water Yupeng Zhao1, Mathilde Hauge Lerche1, Magnus Karlsson1, Rie Beck Olin1, Esben Søvsø Szocska Hansen2, Christoffer Laustsen2, Lars G. Hanson1,3, and Jan Henrik Ardenkjær-Larsen1
1Technical University of Denmark, Kongens Lyngby, Denmark, 2MR Research Centre, Aarhus University, Aarhus, Denmark, 3Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), coronary MRA, myocardial perfusion Motivation: Conventional cardiac MRI plays an essential role in diagnosing coronary artery disease (CAD). However, the image quality is limited by low SNR. Goal(s): Hyperpolarized water can address this problem and be an alternative to Gd-based MR contrast agents for coronary MR angiography (MRA) and myocardial perfusion MRI with minimal safety concerns. Approach: In this work, we demonstrate a procedure to achieve high-resolution motion-free coronary MRA and 3D whole heart myocardial perfusion quantification using hyperpolarized water. Results: The work shows that hyperpolarized water is suited as a positive contrast agent for coronary MRA and myocardial perfusion MRI.
Impact: Compared to previous work on coronary MRA and myocardial perfusion MRI using hyperpolarized 13C/1H, we achieve higher spatial resolution and image quality. Despite invasive catheterisation procedures, the method can be applied in particular situations and has potential for broader use. |
| 3075.
 | 160 | Imaging Tumor Metabolism in Patients with Head & Neck Squamous Cell Carcinoma James A Bankson1,2, Christopher M Walker1,2, Dawid Schellingerhout3, Yunyun Chen4, Brandy Reed5, Keith A Michel1,6, Stephanie Carlon5, Michelle Underwood5, Stacy Hash5, Jerell Jones5, Jose A Gonzalez5, Sandra Schuster5, Ehab Hanna4, William Morrison7, Luana Sousa8, Moin Chariwala9, Andrew Day9, C David Fuller2,7, Vlad C Sandulache10, and Stephen Y Lai2,4,7
1Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 2The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United States, 3Department of Neuroradiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 4Department of Head & Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 5Clinical Research Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 6Imaging Physics Residency Program, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 7Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 8Department of Thoracic-Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 9Center for Advanced Biomedical Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 10Bobby R. Alford Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, Houston, TX, United States Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Gas), pyruvate, metabolism, head and neck, cancer Motivation: Changes in metabolic imaging biomarkers offer tremendous potential for assessing response
and optimizing treatment for patients with head and neck squamous cell
carcinoma (HNSCC). Goal(s): To assess the translational viability of metabolic MRI with hyperpolarized (HP) pyruvate in patients with HNSCC. Approach: Patients with HNSCC are recruited into a prospective imaging study and scanned with HP [1-13C]-pyruvate in a test-retest paradigm before start of therapy. Results: Preliminary data indicates that reproducibility of semi-quantitative measures of tumor metabolism are high, with correlation between test-retest measurements >80% in all voxels that exceed a minimum SNR threshold and correlation >96% in regions identified as tumor. Impact: These results demonstrate that metabolic MRI with hyperpolarized [1-13C]-pyruvate generates sufficient SNR and spatiotemporal resolution to permit reproducible measurement of tumor metabolism in patients with HNSCC. |