| Computer # |
| 1821.
 | 113 | Exploring age-related alterations in brain metabolite levels in healthy adult women using 1H MRS at 3T: Effects of exposure to early-life stress Ralf Mekle1, Lara Fleck2, Martin Bauer2, Dinesh K. Deelchand3, Claudia Buss2,4, Sonja Entringer2,4, Jochen B. Fiebach1, Matthias Endres1,5,6, and Christine Heim2,5
1Center for Stroke Researech Berlin (CSB), Charite Universitätsmedizin Berlin, Berlin, Germany, 2Institute of Medical Psychology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 3Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 4Development, Health, and Disease Research Program, University of California, Irvine, Orange, CA, United States, 5Neurocure Cluster of Excellence, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin, Berlin, Germany, 6Department of Neurology with Experimental Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany Keywords: Spectroscopy, Neuro, early-life stress, adverse childhood experiences, age-related, brain metabolites Motivation: Adversity experienced during early life termed early-life stress (ELS) might increase the risk for neuroinflammation and neurodegenerative disorders in the adult human brain. An enhanced understanding of these relationships will aid in diagnosis and intervention. Goal(s): Our goal was to investigate whether ELS is associated with changes in brain metabolism by using 1H MR spectroscopy. Approach: The interaction between metabolite concentrations obtained from MRS, acquired in adult women, age, and scores of ELS was modeled using non-linear statistics. Results: Higher concentrations with increasing age in individuals exposed to ELS were found for specific metabolites suggesting long-term effects of ELS on the human brain. Impact: Understanding the role of early-life
stress (ELS) in driving neuroinflammatory processes and identification of
specific biomarkers to assess the risk for accelerated cognitive decline and
neurodegenerative disorders in individuals exposed to ELS will aid in early
identification and targeted interventions. |
| 1822.
 | 114 | Rethinking Neurochemical Distributions in White Matter and Grey Matter: Considerations for Improved Magnetic Resonance Spectroscopy Measures Samantha A Leech1,2,3,4, Tiffany K Bell2,3,4, Sarah L Manske1,2, Paul G Mullins5, and Ashley D Harris2,3,4
1Department of Biomedical Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, 2Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 3Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 4Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada, 5School of Psychology, Bangor University, Bangor, United Kingdom Keywords: Spectroscopy, Data Analysis, Neurochemical Concentration Quantification Motivation: Current methods to quantify neurochemical concentrations in magnetic resonance spectroscopy (MRS) assume an equal distribution of neurochemicals between white matter (WM) and grey matter (GM), however, the implications of this assumption have not been explored. Goal(s): We aimed to improve the accuracy of MRS concentration measures by replacing assumptions with calculated values. Approach: We compared calculated concentration ratios of six neurochemicals in WM and GM with the assumed 1:1 ratio to determine the impact of assuming a 1:1 ratio on neurochemical concentrations. Results: The 1:1 ratio assumption yielded estimate errors of up to 55%. Impact: Implementation of our calculated white and grey matter neurochemical distributions will yield magnetic resonance spectroscopy concentration measures that are ~30-55% more accurate than conventional methods. |
| 1823.
 | 115 | Short-Term Neurochemical Effects of Transcutaneous Vagus Nerve Stimulation using 7T Magnetic Resonance Spectroscopy Jessica J. Chen1, Katelyn M. Conn2, Zhou Lan3, Caitlin Ridgewell2,4,5, Huijun Liao1, Wufan Zhao1, Kristin Jensen Heaton2, Bradley M. Ritland2, William H. Neumeier2, and Alexander P. Lin1
1Center for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, 2Military Performance Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, United States, 3Center for Clinical Investigation, Department of Radiology, Brigham and Women's Hospital, 02115, MA, United States, 4Psychiatry, McLean Hospital, Belmont, MA, United States, 5Oak Ridge Institute for Science and Education, Belcamp, MD, United States Keywords: Spectroscopy, Spectroscopy, High-field MRI, Peripheral nerve, Neuroscience, Brain Motivation: Transcutaneous auricular vagus nerve stimulation (taVNS) has shown therapeutic efficacy in treating conditions such as epilepsy and depression. Recently, its potential to improve cognitive performance in healthy adults has been explored. Goal(s): However, little is known about the neurochemical processes underlying performance enhancing outcomes. This study assessed immediate and residual effects of taVNS on neurochemical activity in brain regions associated with attention, vigilance, and stress. Approach: Magnetic resonance spectroscopy was used to non-invasively quantify neurochemical responses immediately after and 60 minutes post-stimulation compared with baseline. Results: Increased myo-inositol was observed in the posterior cingulate immediately after taVNS but not sustained for 60 minutes. Impact: Using magnetic resonance spectroscopy allowed for the evaluation of the short-term neurochemical response across multiple brain regions from transcutaneous auricular vagus nerve stimulation, which helps elucidate the mechanisms of the potential therapeutic and performance-improvement effects achieved from stimulation |
| 1824.
 | 116 | Correlations between 5-ALA fluorescence and 7T MRSI in gliomas: Preliminary observations Sara Huskić1,2, Philipp Lazen1, Cornelius Cadrien1,2, Sagar Acharya1,2, Thomas Roetzer-Pejrimovsky3, Barbara Kiesel2, Julia Furtner4, Lisa Wadiura2, Matthias Preusser5, Wolfgang Bogner1, Karl Roessler2, Siegfried Trattnig1, Georg Widhalm2, and Gilbert Hangel1,2,6
1High Field MR Centre, Medical University of Vienna, Vienna, Austria, 2Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, 3Division of Neuropathology and Neurochemistry, Medical University of Vienna, Vienna, Austria, 4Division of Neuroradiology and Musculoskeletal Radiology, Medical University of Vienna, Vienna, Austria, 5Division of Oncology, Medical University of Vienna, Vienna, Austria, 6Christian Doppler Laboratory for MR Imaging Biomarkers, Vienna, Austria Keywords: Spectroscopy, Tumor, Glioma, 5-ALA Motivation: Heterogeneity in gliomas represents a clinical and diagnostic issue. 5-ALA fluorescence used for intraoperative tumor delineation is different depending on the tumor type. Understanding the dysregulations in the heme pathway using 7T MRSI could help understanding metabolic heterogeneity in tumors. Goal(s): Identifying 7T MRSI metabolites useful for investigating mechanisms of 5-ALA fluorescence and preoperative tumor characterization. Approach: We retrospectively correlated 5-ALA fluorescence from clinical reports to metabolic ratios from 7T MRSI scans in a cohort of 23 patients. Results: 5-ALA correlated with the Gln/tCr ratio (r2=0.597), which also correlated with the tumor grade. Impact: Using 7T MRSI and 5-ALA, we improve guidance for neurosurgeons to resect aggressive tumor hotpots. Furthermore, 7T MRSI could be useful for in vivo studies of metabolic disturbances involved in 5-ALA activation. |
| 1825.
 | 117 | Investigating redox imbalance in first-episode schizophrenia using 7T functional MRS Peter Jeon1, Michael Mackinley1, Kara Dempster2, Sabrina Ford1, Lena Palaniyappan3, and Jean Theberge1
1Western University, London, ON, Canada, 2Dalhousie University, Halifax, NS, Canada, 3McGill University, Montreal, QC, Canada Keywords: Spectroscopy, Molecular Imaging, functional MRS, schizophrenia, redox, glutathione Motivation: Redox imbalance in schizophrenia may help to explain the full range of observable schizophrenia symptoms. Goal(s): Our goal was to use a more appropriate tool to measure dynamic changes in neurometabolites in schizophrenia compared to traditional MRS techniques. Approach: We used functional MRS with a cognitive Stroop task to investigate glutathione dynamics as well as associated glutamate and glutamine dynamics. Results: Glutathione levels increased during task and stayed elevated for healthy subjects, but not for patients. Impact: By demonstrating abnormal anterior cingulate cortex
glutathione response to short-term cognitive battery in first-episode
schizophrenia, we offer novel support and added framework behind potential
redox imbalances in schizophrenia and their utility in managing symptom
treatment. |
| 1826.
 | 118 | Metabolic imaging at 14.1T in the rat brain: preliminary results for PRESS-MRSI vs FID-MRSI Brayan Alves1, Guillaume Briand1,2, Jessie Mosso1,2, Dunja Simicic1,2, Bernard Lanz1,2, and Cristina Cudalbu1,2
1Centre d'Imagerie Biomedical - CIBM, Lausanne, Switzerland, 2Animal Imaging and Technology, EPFL, Lausanne, Switzerland Keywords: Spectroscopy, Spectroscopy, MRSI, UHF, PRESS, FID Motivation: Valuable in the preclinical realm, Magnetic Resonance Spectroscopic Imaging encounters issues with long acquisition time and low signal-to-noise ratio. Numerous excitation schemes allow for metabolic mapping. Goal(s): The current study aims at comparing, with relevant quality metrics, preclinical application of two 1H-MRSI localization schemes at 14.1T: FID-MRSI and PRESS-MRSI. Approach: Both FID and PRESS-MRSI datasets were acquired on the rodent brain in identical conditions (n=3) and processed using the same workflow for objective analysis. Results: An increased coverage and SNR per unit of time were observed for FID-MRSI. Both methods reached similar quantitative results for two different brain regions. Impact: Objective assessment of preclinical 1H-FID and 1H-PRESS-MRSI allows for exploration of their respective limitations and optimization of both localization schemes for different case studies found in preclinical research. |
| 1827.
 | 119 | Investigating Cortical Neurochemical Concentrations in Painful Knee Osteoarthritis using Magnetic Resonance Spectroscopy Samantha A Leech1,2,3,4,5, Marilena M DeMayo3,4,5, Tiffany K Bell3,4,5, Eldridge Batuyong2,6, Marcia Clark6, Geoff Schneider3, Neil White2,6, Kayla Millar5, Charley Hasselaar2, Richard Ng2,6, Sarah L Manske1,2,3, and Ashley D Harris3,4,5
1Department of Biomedical Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, 2McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 3Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 4Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 5Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada, 6Section of Orthopaedic Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada Keywords: Spectroscopy, Osteoarthritis, Chronic Pain Motivation: Alterations in the brain are suggested to contribute to chronic arthritis pain, however there is limited research on the specific neurochemicals and brain regions involved in this process. Goal(s): We aimed to identify neurochemicals and brain regions associated with chronic pain in knee osteoarthritis to understand the brain’s contribution to this condition. Approach: We used magnetic resonance spectroscopy to compare neurochemical levels in four pain-related brain regions between cohorts of patients with painful knee osteoarthritis and healthy controls. Results: Significantly lower levels of GABA and myoinositol in the anterior cingulate cortex in the knee osteoarthritis group suggests potential disrupted inhibitory processes and neuroinflammation. Impact: Patients with painful knee osteoarthritis exhibited significantly lower levels of GABA and myoinositol in the anterior cingulate cortex compared to healthy controls. These findings illuminate the anterior cingulate cortex as a potential therapeutic target for knee osteoarthritis pain management. |
| 1828.
 | 120 | Non-Water-Suppressed Semi-LASER Localization for MR Spectroscopy of the Human Skeletal Muscle at 3T Manoj K Sarma1,2, Mahrshi Jani1, Yeison Rodriguez1, Bei Zhang1,2, and Anke Henning1,2
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Radiology, UT Southwestern Medical Center, Dallas, TX, United States Keywords: Spectroscopy, Spectroscopy, Skeletal muscle, SVS, pulse sequence Motivation: Due to the dependence on the type and orientation of the skeletal muscle, it is a challenge to perform 1H MRS to characterize the muscle features in this highly organized structure. Goal(s): The aim of this work was to implement a non-water-suppressed semi-LASER (sLASER) sequence to characterize up- and downfield metabolites in human skeletal muscle in vivo at 3T. Approach: This was achieved through optimizing the crusher scheme and phase cycling schemes in sLASER and combining it with metabolite cycled. Results: High quality spectra were obtained from different muscle fibers of 8 healthy volunteers to characterize both up- and downfield metabolites. Impact: We
demonstrated the application of metabolite-cycled semi-LASER spectroscopy in
human skeletal muscles at 3T. Up- and downfield parts of the spectrum were
detected with high quality enabling the detection of important metabolites including
carnosine providing unique insight into human physiology. |
| 1829.
 | 121 | Mapping of cerebral metabolite concentrations in brain tumors using 1H-MRSI and quantitative MRI Dennis C. Thomas1,2,3,4, Seyma Alcicek1,2,3,4, Andrei Manzhurtsev1,2,3,4, Elke Hattingen1,2,3,4, Katharina J. Wenger*1,2,3,4, and Ulrich Pilatus*1,5
1Institute of Neuroradiology, Goethe University Frankfurt, University Hospital Frankfurt, Frankfurt, Germany, 2University Cancer Center Frankfurt (UCT), Frankfurt am Main, Germany, 3Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany, 4German Cancer Research Center (DKFZ) Heidelberg and German Cancer Consortium (DKTK), Heidelberg, Germany, 5Brain Imaging Center, Goethe University, Frankfurt, Germany Keywords: Spectroscopy, Spectroscopy, Water referencing Motivation: Absolute quantification of the 1H MRS metabolites remains a challenge for 2D MRSI, due to long acquisition times for the unsuppressed water reference and the multiple biases present due to relaxation and inhomogeneity.
Goal(s): To propose a water reference method combining single voxel STEAM and quantitative MRI (qMRI).
Approach: The method is demonstrated and tested against a standard water referencing method on one healthy subject. Its application is demonstrated in a brain tumor patient.
Results: Apart from obtaining absolute metabolite concentrations, corrected for all water relaxation times, 4 qMRI maps (PD, T1, T2* and QSM) maps are also generated. Impact: We propose a method for absolute quantification of cerebral metabolites in 2D MRSI by combining STEAM and quantitative MRI. The method is tested against a reference method in a healthy subject and its application demonstrated for a brain tumor patient. |
| 1830.
 | 122 | Evidence of impaired dACC glutamate modulation under task-specific motor control in obsessive compulsive disorder (OCD) using 1H fMRS Jeffrey A Stanley1,2, Jillian M Eichstaedt2,3, Dalal Khatib1,2, Phil Easter1, Rebecca Neill1, Usha Rajan1, Julia Bellamy1, David R Rosenberg1, and Vaibhav A Diwadkar1,2
1Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States, 2Brain Imaging Research Division, Wayne State University, Detroit, MI, United States, 3Translational Neuroscience Program, Wayne State University, Detroit, MI, United States Keywords: Spectroscopy, Spectroscopy, 1H MRS, fMRS, OCD Motivation: The neurobiological mechanisms of poor top-down motor control in OCD are not well understood. Goal(s): Our goal was to investigate neurobiological differences in glutamate modulation across different motor/inhibitory control responses in OCD compared to healthy controls. Approach: 1H fMRS was conducted in adolescents with OCD and healthy controls. Results: Task-specific impairments to the dACC glutamate modulation were observed in OCD compared to healthy controls. Impact: These results providing compelling evidence towards characterizing neurosignaling changes in OCD pathophysiology. |
| 1831.
 | 123 | Simultaneous Multi-Region Detection of GABA+ and Glx using 3D Spatially Resolved SLOW-editing and EPSI-readout at 7T Guodong Weng1,2, Johannes Slotboom1,2, and Piotr Radojewski1,2
1Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland, 2Translational Imaging Center, sitem-insel, Bern, Switzerland, Bern, Switzerland Keywords: Spectroscopy, Molecular Imaging, GABA, Spectral editing, MRSI Motivation: Robust B0 and B1+ detection of GABA+ and Glx in 3D or whole brain MRSI using spectral editing is challenging at 7T. Goal(s): To simultaneously detect GABA+ and Glx in multi-regions and generate 3D maps using SLOW-editing for human brain at 7T. Approach: SLOW-EPSI was performed on 5 healthy volunteers. Results: Our method is robust to [-0.3 ppm, +0.3 ppm] B0 and [40%, 250%] B1+ for GABA+/Glx editing. 9-minute acquisition is sufficient for any arbitrarily shaped volume quantification. 18-27 minutes acquisition is sufficient for 3D mapping of GABA+. 9-18 minutes acquisition is sufficient for 3D mapping of Glx. Impact: Our work presents a large 3D or whole-brain MRSI tool for GABA+ and Glx quantification and mapping at 7T, which allows clinicians to examine changes in GABA+ and Glx in the brain for any arbitrarily shaped volume. |
| 1832.
 | 124 | Weight loss predicts the modulation of dACC glutamate during inhibitory control that is specific to food-cues: Evidence from ¹H fMRS Jillian M Eichstaedt1,2, Rachel Sochocki3, Dalal Khatib2, Nicole Miller4, Vaibhav A Diwadkar2, Paul Burghardt1,3, Amy Rothberg4, and Jeffrey A Stanley1,2
1Translational Neuroscience Program, Wayne State University, Detroit, MI, United States, 2Brain Imaging Research Division, Psychiatry and Behavioral Neuroscience, Wayne State University, Detroit, MI, United States, 3Department of Nutrition and Food Science, Wayne State University, Detroit, MI, United States, 4Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States Keywords: Spectroscopy, Spectroscopy, fMRS, 1H MRS Motivation: The neurobiological mechanisms involved in poor weight loss maintenance are not understood. Goal(s): Our goal was to investigate neurobiological differences in glutamate modulation across different motor/inhibitory control responses after completion of a clinical weight loss program. Approach: 1H fMRS was conducted in a pilot sample who had completed a clinical weight loss program. Results: The presence of food cues as the stimuli influenced the glutamate modulation during inhibitory control responses. Impact: With further investigation, our preliminary evidence of a food-cue specific difference in glutamate modulation may fuel better treatment plans to support more successful maintenance of weight loss. |
| 1833.
 | 125 | Detection of Elevated Succinate in Brain During Circulatory Arrest: A 3T 1H MR Spectroscopy Study Daniel Spielman1, Meng Gu1, and Ralph Hurd1
1Radiology, Stanford University, Stanford, CA, United States Keywords: Spectroscopy, Spectroscopy, Succinate Motivation: To measure succinate in brain during circulatory arrest in a piglet model of cardiac bypass. Goal(s): Dynamic measurement of succinate using 3T MR spectroscopy Approach: Spectral fits of the archived data were used to create dynamic plots of succinate, to provide statistics, and to generate simulated spectra for validation. Results: Elevation of succinate during circulatory arrest was observed and validated. Fitting bias was evaluated over the linewidths and signal-to-noise S/Ns of the archived data. Succinate increase did not appear to be dependent on bypass temperature. Succinate elevation was not observed with antegrade cerebral perfusion. Impact: Elevated succinate during ischemia has been identified as a source of ischemic-reperfusion injury. The ability to measure increased succinate during ischemia plus the ability to intercede with succinate inhibitors may have important consequence prior to re-perfusion in bypass and stroke. |
| 1834.
 | 126 | Metabolic biomarkers of IDH status in gliomas by in vivo Magnetic Resonance Spectroscopy Capucine Cadin1, Thamila Chetouane1, Gerd Melkus2, François-Xavier Lejeune1,3, Dinesh Deelchand4, Stéphane Lehericy1, Malgorzata Marjanska4, Thanh Binh Nguyen2, and Francesca Branzoli1
1Paris Brain Institute - ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne University, UMR S 1127, Paris, France, 2The Ottawa Hospital, Ottawa, ON, Canada, 3Data Analysis Core, Paris Brain Institute, Paris, France, 4Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States Keywords: Spectroscopy, Spectroscopy, Glioma, IDH mutation, brain metabolites, ROC analysis, diagnosis Motivation: Reliable noninvasive quantification of D-2-hydroxyglutarate (2HG) for diagnosis of isocitrate dehydrogenase (IDH)-mutant gliomas is challenging.
Goal(s): To discriminate between IDH-mutant and wild-type gliomas based on their full metabolic profile. Approach: Partial Least Squares Discriminant Analysis (PLS-DA) was used to discriminate IDH-mutants from wild-types using in vivo 3T MRS data from 47 patients with a newly diagnosed glioma.
Results: Higher 2HG and lower glutamate + glutamine, glutamate, glycine, and glutathione were observed in IDH-mutants compared to wild-types. The PLS-DA model showed higher accuracy (AUC = 0.949) compared to 2HG alone (AUC = 0.753), underscoring the superiority of a comprehensive approach over single metabolite analysis.
Impact: Exploring in vivo metabolic alterations beyond D-2-hydroxyglutarate is crucial for enhancing diagnostic accuracy in detection of IDH mutations in patients with gliomas, as well as for a deeper understanding of the fundamental biological consequences of this mutation. |
| 1835.
 | 127 | Reliability and Reproducibility of Neurochemical Profiles Obtained with sLASER and STEAM at 3T and 7T in Lower and Upper Limb Regions Zeinab Eftekhari1,2, Thomas B Shaw1,3, Dinesh K Deelchand4, Małgorzata Marjańska4, Wolfgang Bogner5, and Markus Barth1,2,3
1Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, 2ARC Training Centre for Innovation in Biomedical Imaging Technology (CIBIT), The University of Queensland, Brisbane, Australia, 3School of Electrical Engineering and Computer Science, The University of Queensland, Brisbane, Australia, 4Centre for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 5High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria Keywords: Spectroscopy, Spectroscopy, sLASER, STEAM, 3T and 7T, Longitudinal Reproducibility, High-Field MRI, Ultrahigh-Field MRI, Magnetic Resonance Spectroscopy Motivation: The test-retest of STEAM and sLASER at both fields using the same subjects has not been investigated. Goal(s): The aim was to evaluate the reliability using Intraclass Correlation Coefficients(ICC) and reproducibility using Coefficient of Variations (CV%) of Glutamate, Glutamine, and N-acetyl-aspartate quantification at 3T and 7T in the human motor cortex using sLASER and STEAM sequences. Approach: Subjects were scanned a week apart using both sequences at both field strengths. Voxel locations were in Paracentral Lobule (PCL) and Precentral Gyrus (PrCG). Results: sLASER, particularly at 7T, demonstrated superior performance in both regions within a reasonable timeframe,making it the recommended sequence for longitudinal studies.
Impact: This study’s findings offer valuable insights for researchers conducting longitudinal studies using MRS. The improved reliability and reproducibility of the sLASER technique, particularly at 7T, enable more precise tracking of disease progression, potentially leading to improved disease tracking. |
| 1836.
 | 128 | The Impact of Myo-Inositol on Cognitive Performance: A 7T Magnetic Resonance Spectroscopy Study Maria Collee1,2, Ravichandran Rajkumar1,2, Ezequiel Farrher2, Jana Hagen1,2, Shukti Ramkiran1,2,3, Gereon Schnellbächer1,2, Tanja Veselinovic1,2,4, Nadim Jon Shah2,4,5,6, and Irene Neuner1,2,3,4
1Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, 2Institute of Neuroscience and Medicine, INM-4, Forschungszentrum Jülich GmbH, Jülich, Germany, 3Center for Computational Life Sciences, RWTH, Aachen, Germany, 4JARA – BRAIN – Translational Medicine, Aachen, Germany, 5Neurology, RWTH Aachen University, Aachen, Germany, 6Institute of Neuroscience and Medicine, INM-11, Forschungszentrum Jülich GmbH, Jülich, Germany Keywords: Spectroscopy, Spectroscopy, 7T ultra high field MRS, Cognition Motivation: This study aims to contribute novel insights into the potential cognitive role of myo-inositol and its implications for brain metabolism using 7 Tesla magnetic resonance spectroscopy (7T-MRS). Goal(s): Our primary goal was to determine if myo-inositol concentrations within the posterior cingulate cortex (PCC) influence cognitive performance. Approach: Ultra-high field 7T-MRS was used to measure myo-inositol concentrations in relation to cognitive performance, as assessed with the Trail-Making-Test (TMT-A/B). Data analysis involved multiple linear regressions with covariate control and bootstrapping for robustness. Results: Our study reveals a significant (p<0.05) positive association between higher myo-inositol levels in the PCC and enhanced cognitive performance in TMT-A/B. Impact: This study suggests the potential of myo-inositol as a biomarker for cognitive functioning. Furthermore, the findings contribute to our understanding of brain neurochemistry, supporting the advancement of personalised medicine for cognitive impairments. |