ISSN# 1545-4428 | Published date: 19 April, 2024
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At-A-Glance Session Detail
   
Young Investigator Award Poster Session
Digital YIA Poster
YIA
Monday, 06 May 2024
Exhibition Hall (Hall 403)
13:45 -  15:45
Session Number: D-YIA
No CME/CE Credit

Screen #
13:450001.
1MRI Assessment of Cerebral White Matter Microvascular Hemodynamics Across the Adult Lifespan
Nikou L. Damestani1,2, John Jacoby1, Christa B. Michel1, Barnaly Rashid1,3, David H. Salat1,2,4, and Meher R. Juttukonda1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Department of Neurology, Harvard Medical School, Boston, MA, United States, 4Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, United States

Keywords: YIA, White Matter

Motivation: The mechanisms underlying age-related structural neurodegeneration are not well understood, limiting our knowledge of atypical versus typical aging. 

Goal(s): Our goal was to use data involving advanced hemodynamic and structural MRI techniques tailored to white matter to characterize the aging process.

Approach: We used data from a large cohort of the Human Connectome Project in Aging to investigate the relationship between brain blood flow and white matter tract microstructural integrity.

Results: We found strong relationships between white matter hemodynamics and tract integrity that were affected by both age and sex.

Impact: These findings could reveal potential underlying physiological mechanisms behind structural changes during typical aging. This could help us understand healthy brain aging and encourage future research to target hemodynamic biomarkers to understand neurodegeneration.

13:450002.
2Assessment of Complex Flow Patterns in Patients with Carotid Webs, Patients with Carotid Atherosclerosis, and Healthy Subjects Using 4D Flow MRI
Retta El Sayed1, Charlie C Park2, Zahraw Shah1, Fadi B Nahab3, Diogo C. Haussen3, Jason Allen3, and John N Oshinski1
1Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, United States, 2Department of Radiology & Imaging Sciences, Emory University, Atlanta, GA, United States, 3Department of Neurology, Emory University, Atlanta, GA, United States

Keywords: Flow, Blood vessels, 4D Flow MRI

Motivation: The motivation of this work is to understand the hemodynamics parameters in subjects with carotid web (CaW), atherosclerosis subjects with similar luminal narrowing, and normal subjects using 4D Flow MRI.

Goal(s): The main goal of this work is to quantify parameters related to vascular dysfunction including wall shear stress (WSS) and oscillatory shear index (OSI). 

Approach: 4D Flow MRI was utilized to prospectively scan subjects with CaW and hemodynamic parameters were compared to subjects with mild atherosclerosis and healthy volunteers.

Results: The results show that subjects with CaW have larger regions of complex blood flow represented by low WSS and high OSI. 

Impact: This study improves our understanding of disturbed hemodynamics caused by CaWs in comparison to atherosclerosis, which may explain the mechanism of thrombus formation and lay the groundwork for stroke risk assessment in patients with CaW.

14:150003.
1Cross-Vendor Multiparametric Mapping of the Human Brain Using 3D-QALAS: A Multicenter & Multivendor Study
Shohei Fujita1,2,3,4, Borjan Gagoski4,5, Ken-Pin Hwang6, Akifumi Hagiwara1, Marcel Warntjes7,8, Issei Fukunaga1, Wataru Uchida1, Yuya Saito1, Towa Sekine1, Rina Tachibana1, Tomoya Muroi1, Toshiya Akatsu1, Akihiro Kasahara2, Ryo Sato2, Tsuyoshi Ueyama2, Christina Andica1,9, Koji Kamagata1, Shiori Amemiya2, Hidemasa Takao2, Yasunobu Hoshino10, Yuji Tomizawa10, Kazumasa Yokoyama10, Berkin Bilgic3,4,11, Nobutaka Hattori10, Osamu Abe2, and Shigeki Aoki1
1Department of Radiology, Juntendo University, Tokyo, Japan, 2Department of Radiology, The University of Tokyo, Tokyo, Japan, 3Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 4Department of Radiology, Harvard Medical School, Boston, MA, United States, 5Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 6Department of Imaging Physics,, MD Anderson Cancer Center, Houston, TX, United States, 7SyntheticMR, Linköping, Sweden, 8Center for Medical Imaging Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 9Faculty of Health Data Science, Juntendo University, Chiba, Japan, 10Department of Neurology, Juntendo University, Tokyo, Japan, 11Harvard/MIT Health Sciences and Technology, Cambridge, MA, United States

Keywords: YIA, Neuro

Motivation: To address the unmet need for a cross-vendor, multiparametric technique to facilitate data pooling across sites.

Goal(s): To evaluate a vendor-standardized multiparametric mapping scheme based on 3D-QALAS for whole-brain T1, T2, and proton density (PD) mapping.

Approach: Intra-scanner repeatability and inter-vendor reproducibility were evaluated in vivo on five different 3T systems from four vendors (GE, Philips, Siemens, and Canon). Patients with multiple sclerosis were scanned on systems from different vendors to assess the feasibility of the scheme in real-world clinical settings.

Results: 3D-QALAS provided T1, T2, and PD with coefficient of variations <4.0% using 3T scanners from different manufacturers.

Impact: The four major vendors used in this study constitute a considerable portion of the global installation base, demonstrating the value of cross-vendor quantitative technique 3D-QALAS for imaging in clinical sites with multiple vendors, as well as in multicenter research settings.

14:150004.
2Any-nucleus Distributed Active Programmable Transmit Coil
Victor Han1, Charlie P. Reeder1, Miriam Hernández-Morales1, and Chunlei Liu1
1University of California, Berkeley, Berkeley, CA, United States

Keywords: Non-Array RF Coils, Antennas & Waveguides, Non-Proton, Multinuclear, RF coil, X-nuclei

Motivation: There are 118 elements. Nearly all elements have NMR active isotopes and 39 different nuclei have been shown to have biological relevance. Despite this, most of today’s MRI is based on only one nucleus – 1H.

Goal(s): To significantly reduce the cost and complexity of imaging all potential nuclei.

Approach: We present the Any-nucleus Distributed Active Programmable Transmit Coil (ADAPT Coil), with fast switches integrated into the coil itself which allows it to selectively excite any nucleus using digital controls.

Results: Using the ADAPT Coil, we acquired 1H, 23Na, 2H, and 13C phantom images and 1H and 23Na ex vivo images at 3T.

Impact: The ADAPT Coil enables arbitrary nucleus excitation in high field MRI, significantly reducing the cost and technological barriers of clinical translation of X-nuclei research. X-nuclei benefits include improved early diagnosis and treatment evaluation for cancer, osteoarthritis, Alzheimer’s, and many more.

14:450005.
1Diffusion-Weighted SPECIAL Improves the Detection of J-Coupled Metabolites at Ultrahigh Magnetic Field
Jessie Mosso1,2,3, Dunja Simicic2,3, Bernard Lanz2,3, Rolf Gruetter1, and Cristina Cudalbu2,3
1LIFMET, EPFL, Lausanne, Switzerland, 2CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 3Animal Imaging and Technology, EPFL, Lausanne, Switzerland

Keywords: YIA, Diffusion/other diffusion imaging techniques, Diffusion-weighted MR spectroscopy, rodent brain, high field, SPECIAL, glutamine, J-coupled metabolites

Motivation: Diffusion-weighted MR spectroscopy (dMRS) uniquely probes cell-specific tissue microstructure in vivo but most sequences suffer from long TE leading to signal loss by J-evolution and T2 relaxation.

Goal(s): To propose an alternative dMRS sequence (DW-SPECIAL) with a shorter TE while preserving the benefits of the current gold-standard rodent sequence at high field (STE-LASER).

Approach: DW-SPECIAL was tested in vivo in the rat brain and compared to STE-LASER.

Results: DW-SPECIAL halved the minimum TE while reducing specific absorption rate compared to STE-LASER, thereby 1) improving the J-coupled metabolites’ diffusion properties estimation and 2) offering a new candidate sequence for human dMRS.

Impact: With its shorter TE, our newly proposed DW-SPECIAL can serve as an alternative to STE-LASER when strongly J-coupled metabolites like glutamine are investigated, thereby extending the range of accessible metabolites in the context of diffusion-weighted MRS acquisitions at high field.

14:450006.
2Fetal MRI-based body and adiposity quantification for small for gestational age perinatal risk stratification
Aviad Rabinowich1,2,3, Netanell Avisdris1,4, Bossmat Yehuda1,5, Ayala Zilberman3,6, Tamir Graziani2,3, Bar Neeman2,3, Bella Specktor-Fadida4, Dafna Link-Sourani1, Yair Wexler7, Jacky Herzlich3,8, Karina Krajden Haratz3,6, Leo Joskowicz4,9, Liat Ben Sira2,3, Liran Hiersch3,6, and Dafna Ben Bashat1,3,5
1Sagol Brain Institute, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, 2Department of Radiology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, 3Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 4School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel, 5Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel, 6Department of Obstetrics and Gynecology, Lis Hospital for Women, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, 7School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel, 8Neonatal Intensive Care Unit, Dana Dwek Children's Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, 9Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

Keywords: YIA, Fetus

Motivation: Small for gestational age (SGA) fetuses are undernourished and at higher risk for adverse outcomes; however, conventional assessment methods exhibit limited sensitivity.

Goal(s): To stratify perinatal risk using MRI-based body composition metrics.

Approach: TruFISP and 2-points Dixon images were used to compute the total fetal volume (TFV), fat-to-body volume ratio (FBVR) and adipose tissue fat signal fraction (FSF) using deep-learning segmentation.

Results: SGA fetuses (N=40) with lower FBVR were more likely to require obstetric interventions because of non-reassuring status, while those with reduced TFV were prone to adverse neonatal outcomes. The model’s sensitivity/specificity rates are 85.7%/87.5% and 82.35%/86.4%, respectively.

Impact: Quantifying fetal body composition through MRI can offer additional insights into the severity of small for gestational age complicated pregnancies and may help in stratifying perinatal risk.

15:150007.
1Dynamic lung water magnetic resonance imaging during exercise stress
Felicia Seemann1, Ahsan Javed1, Jaffar M Khan1, Christopher G Bruce1, Rachel Chae1, Korel Yildirim1, Amanda Potersnak1, Haiyan Wang1, Scott Baute1, Rajiv Ramasawmy1, Robert J Lederman1, and Adrienne E Campbell-Washburn1
1Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States

Keywords: YIA, Data Acquisition, Acquisition & Analysis, Body, Lung, Lung water, Heart failure, Translational Studies

Motivation: Quantification of lung water during exercise is of interest for early diagnosis of heart failure.

Goal(s): To develop a time-resolved 3D MRI method to quantify lung water in transitions between rest and exercise.

Approach: We derive quantitative time-resolved lung water density (LWD) maps using a motion corrected sliding-window image reconstruction. We included 12 healthy controls and 2 patients with heart failure, and a porcine model of mitral regurgitation (n=5).

Results: We measured a peak exercise ΔLWD=16±6.8% in controls, but detected no changes during rest (ΔLWD=-1.4±3.5%, p=0.18). Accumulation rates were slower in patients (2.0±0.1%/min) vs controls (2.6±0.9%/min). Animals developed ΔLWD=3.3±1.5%.

Impact: Exercise-induced changes in lung water can be dynamically quantified using a continuous 3D MRI acquisition with a sliding-window and motion corrected image reconstruction, which may have clinical utility in unmasking latent heart failure at early stages of disease.

15:150008.
2Accelerated 2D Cartesian MRI with an 8-channel local B0 coil array combined with parallel imaging
Rui Tian1, Martin Uecker2,3,4,5, Mathias Davids6,7, Axel Thielscher8,9, Kai Buckenmaier1, Oliver Holder1, Theodor Steffen1, and Klaus Scheffler1,10
1High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2Institute of Biomedical Imaging, Graz University of Technology, Graz, Austria, 3Institute for Diagnostic and Interventional Radiology, University Medical Center Göttingen, Göttingen, Germany, 4German Centre for Cardiovascular Research (DZHK), Partner Site Göttingen, Göttingen, Germany, 5BioTechMed-Graz, Graz, Austria, 6A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 7Harvard Medical School, Boston, MA, United States, 8Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark, 9Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark, 10Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany

Keywords: YIA, Hybrid & Novel Systems Technology, Physics & Engineering, Acquisition & Reconstruction, New Trajectories & Spatial Encoding Methods, Acquisition Methods, nonlinear gradient

Motivation: The inherently slow MRI scans can be accelerated through rapid modulation of nonlinear gradient fields; however, its fundamental mechanisms and limits remain incompletely understood and validated.

Goal(s): We investigate accelerated MRI with flexible modulations of nonlinear B0 fields using a custom-built local B0 array.

Approach: The sampling theory is extended to rigorously compare nonlinear field modulation schemes in a quantitative k-space. A novel field calibration technique is proposed to enhance reconstruction. With safety evaluations, we perform in-vivo accelerated scans.

Results: Our in-vivo 2D FLASH scans make significant steps to speed up MRI with local B0 array, achieving eight-fold joint acceleration with parallel imaging.

Impact: For the first time, the sampling efficiency of nonlinear gradients in the entire k-space is quantitatively visualized, allowing rigorous comparison of distinct B0 modulations. Furthermore, the field estimation technique enables fast and robust in-vivo scans accelerated by flexible nonlinear fields.