ISSN# 1545-4428 | Published date: 19 April, 2024
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At-A-Glance Session Detail
   
Dementia & Neurodegenerative Diseases
Oral
Neuro
Tuesday, 07 May 2024
Room 325-326
15:45 -  17:45
Moderators: Shannon Kolind & Yuhei Takado
Session Number: O-45
CME Credit

15:450660.
Relationships between Brain Microstructures and Visual Field Loss Patterns in Glaucoma using Diffusion MRI and Archetypal Analysis
Yueyin Pang1, Carlos Parra1, Ji Won Bang1, Els Fieremans2, Gadi Wollstein1, Joel S Schuman3,4,5, Mengyu Wang6, and Kevin C Chan1,2
1Department of Ophthalmology, New York University Grossman School of Medicine, New York, NY, United States, 2Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 3Wills Eye Hospital, Philadelphia, PA, United States, 4Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, United States, 5Department of Biomedical Engineering, Drexel University, Philadelphia, PA, United States, 6Schepens Eye Research Institute, Harvard Medical School, Boston, MA, United States

Keywords: Other Neurodegeneration, Neurodegeneration

Motivation: In bilateral glaucoma, visual field loss often spares complementary regions between eyes to optimize residual vision, but the underlying mechanisms are unknown.

Goal(s): Investigate how brain microstructural environment relates to regional visual field loss patterns in glaucoma.

Approach: Advanced diffusion MRI parameters of optic radiation integrity were correlated with glaucomatous visual field loss patterns using partial correlation and archetypal analyses.

Results: Diffusion MRI metrics generally correlated with overall visual field loss. Complementary archetypal loss patterns were also found between eyes when associating pointwise visual field to certain MRI metrics sensitive to axonal/glial integrity and neuroinflammation, suggesting their involvement in influencing residual binocular vision. 

Impact: Advanced neuroimaging combined with computational analysis can provide insights into the brain’s role in influencing preferential damage to maximize retained binocular vision in glaucoma. Diffusion MRI holds promise for assessing glaucoma progression and brain plasticity for guiding vision preservation.

15:570661.
In vivo mapping of sodium homeostasis disturbances in individual ALS patients: a brain 23Na MRI study
Aude-Marie Grapperon1,2, Mohamed Mounir El Mendili2, Adil Maarouf2, Jean-Philippe Ranjeva2, Maxime Guye2, Annie Verschueren1, Shahram Attarian1, and Wafaa Zaaraoui2
1APHM, Hôpital de la Timone, Referral Centre for Neuromuscular Diseases and ALS, Marseille, France, 2Aix Marseille Univ, CNRS, CRMBM-CEMEREM, Marseille, France

Keywords: Other Neurodegeneration, Neurodegeneration, non-proton; sodium; ALS

Motivation: ALS is a neurodegenerative disease leading to progressive motor deficit and death within few years. There is an unmet need to identify non-invasive biomarkers at the individual level to predict disease progression.

Goal(s): To study disease severity at the individual level in ALS by mapping abnormal sodium homeostasis using brain 23Na-MRI.

Approach: 27 ALS patients were explored by brain 23Na-MRI. Individual map of abnormal total sodium concentration (TSC) was computed for each patient compared to a local database of 62 controls.

Results: This study mapping sodium homeostasis disturbances at the individual level in ALS patients evidenced association between TSC increase and disease severity.

Impact: This pilot study mapping sodium homeostasis disturbances at the individual level in ALS patients through 23Na-MRI evidenced association between TSC increase and disease severity and may be a future biomarker to help stratifying patients and evaluating new therapeutics.

16:090662.
Longitudinal MRA Tortuosity Metric Measurements in a Population-based Study
Ziyang Xu1, Melissa Caughey2, Sile Wang1, Xinwei Zhou3, and Ye Qiao1
1Department of Radiology, Johns Hopkins Hospital, Baltimore, MD, United States, 2Joint Department of Biomedical Engineering, University of North Carolina & North Carolina State University, Chapel Hill, NC, United States, 3Johns Hopkins Hospital, Baltimore, MD, United States

Keywords: Dementia, Blood vessels, MRA

Motivation: Current understanding of dolichoectasia has largely been drawn from patients with clinical need for brain imaging in the cross-sectional settings.

Goal(s): To characterize the longitudinal changes in brain MRA geometry vessel metrics and their associations with demographic variables, imaging biomarkers and cognitive performance.

Approach: Basic demographic and clinical information were compared between two groups w/wo MRI metric measurement change using two-sample t-tests. The associations between MRI metrics and cognitive decline or incidence dementia were tested using logistic regression.

Results: MRA geometry vessel metric change was not associated with the cognitive decline over time (3.6-8 years). Baseline cognitive score can predict future cognitive performance. 

Impact: Clinical predictors of worsening dolichoectasia are unknown. Although MRA geometry vessel metric changes are not significant with cognitive decline, demographic variables show significance on some metric difference. Baseline cognitive score can also predict cognitive change.

16:210663.
Deformation-based morphometry reveals lower brain tissue volume in autopsy confirmed limbic age-related TDP-43 encephalopathy (LATE)
Mahir Tazwar1, Arnold M Evia2, Abdur Raquib Ridwan2, David A Bennett2, Julie A Schneider2, and Konstantinos Arfanakis1,2
1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, United States

Keywords: Other Neurodegeneration, Aging, LATE-NC, TDP-43, Neuropathology, Aging, Postmortem MRI

Motivation: The association of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) with brain morphometry has not been thoroughly investigated.

Goal(s): To investigate gray and white matter morphometric abnormalities in LATE-NC in a large number of community-based older adults.

Approach: This study combined deformation-based morphometry (DBM) in ex-vivo brain MRI and detailed neuropathological data on the same community-based older adults (N=897), and investigated the association of LATE-NC with brain morphometric characteristics using voxel-wise linear regression models.

Results: LATE-NC was associated with lower volume in gray and white matter areas of temporal and frontal lobes and basal ganglia, consistent with the known pathological distribution of LATE-NC.

Impact: The pattern of morphometric abnormality in LATE-NC that was generated in the present work may potentially be used in combination with other imaging and clinical information towards the development of a marker of this devastating neuropathology.

16:330664.
Difference in the spatial pattern of brain atrophy associated with Alzheimer’s and LATE neuropathology
Khalid Saifullah1, Abdur Raquib Ridwan2, David A. Bennett2, Julie A. Schneider2, and Konstantinos Arfanakis1,2
1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, United States

Keywords: Other Neurodegeneration, Aging, LATE, Alzheimer’s, Neuropathology, Aging, Postmortem MRI

Motivation: Alzheimer’s disease neuropathologic change (AD-NC) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) are common age-related pathologies and are associated with brain atrophy, especially in the medial temporal lobe. However, the difference in atrophy patterns associated with the two pathologies is not well known.

Goal(s): To investigate the difference in brain atrophy patterns associated with AD-NC and LATE-NC.

Approach: Ex-vivo MRI and detailed neuropathology were combined in a large number of community-based older adults that came to autopsy.

Results: LATE-NC stages 2 or 3 are associated with more atrophy in the anterior portion of the hippocampus compared to moderate or severe AD-NC.

Impact: Atrophy in the anterior portion of the hippocampus is more severe with LATE-NC stages 2 or 3 than with moderate or severe AD-NC.

16:450665.
Hyperintense globus pallidus rim sign on 7T MRI is a novel biomarker of neurological Wilson’s disease
Dongning Su1, Zhijin Zhang1, Zhe Zhang2, Sujun Zheng3, Tingyan Yao4, Yi Dong5, Wanlin Zhu2, Ning Wei2, Yue Suo2, Xinyao Liu2, Huiqing Zhao1, Zhan Wang1, Huizi Ma1, Wei Li1, Junhong Zhou6, Joyce S. T. Lam7, Tao Wu1, Yuan Li8, Petr Dusek9, A. Jon Stoessl7, Xiaoping Wang10, Jing Jing2, and Tao Feng1
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 2Tiantan Neuroimaging Center of Excellence, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 3Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China, 4Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, China, 5Senior Department of Hepatology, the Fifth Medical Center of PLA General Hospital, Beijing, China, 6Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Roslindale, MA, United States, 7Pacific Parkinson’s Research Centre, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada, 8MR Research Collaboration Team, Siemens Healthineers, Beijing, China, 9Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic, 10Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Keywords: Other Neurodegeneration, Neurodegeneration, Wilson's disease; 7T MRI; biomarker; metal deposition pattern

Motivation: Excessive subcortical metal deposition seen on susceptibility imaging has suggested a characteristic pattern in neurological Wilson’s disease (NWD).

Goal(s): To develop a novel imaging biomarker of NWD using 7T SWI.

Approach: WD patients, monoallelic ATP7B variant carriers, health controls, and patients with comparable clinical or imaging manifestations were recruited for development of a novel biomarker of NWD and  exploratory comparative analysis. All underwent 7T SWI with quantitative susceptibility mapping and principal component analysis performed.

Results: The novel biomarker of NWD termed "hyperintense globus pallidus rim sign" showed high diagnostic accuracy. It revealed a special metal deposition pattern in the lenticular nucleus in NWD.

Impact: A novel imaging biomarker of neurological Wilson’s disease (NWD) termed "hyperintense globus pallidus rim sign" could aid the diagnosis and monitoring of NWD.

16:570666.
Magnetic Resonance Elastography Based Measure of Compressibility in Normal Pressure Hydrocephalus and Alzheimer’s Disease
Pragalv Karki1, Matthew C Murphy1, Petrice M Cogswell1, Armando Manduca1,2, Richard L Ehman1, and John Huston III1
1Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, United States, 2Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, United States

Keywords: Dementia, Alzheimer's Disease, Biomarker's, Novel contrast mechanisms

Motivation: Magnetic resonance elastography (MRE) is typically used to assess shear mechanical properties of a tissue. A new measure related to the compressibility of a tissue could provide new insights into disease processes.

Goal(s): To test a new measure related to the tissue compressibility in application to neurological disorders.

Approach: A measure of compressibility was defined as the ratio of the magnitude of the divergence over the magnitude of the curl of displacements.

Results: Normal pressure hydrocephalus and Alzheimer’s disease displayed distinct patterns of compressibility measure compared to the control group.

Impact: An MRE-based compressibility measure demonstrates unique patterns in normal pressure hydrocephalus and Alzheimer’s disease. This may provide new insights into disease processes and guides future research.  

17:090667.
Myotonic Dystrophy type 1: susceptibility in Thalamus and Brainstem as biomarker of clinical impairment
Cristiana Fiscone1, Magali Jane Rochat2, Silvia De Pasqua3, Micaela Mitolo2,4, Claudio Bianchini1, Gianfranco Vornetti1,2, Fiorina Bartiromo2, David Neil Manners2,5, Patrizia Avoni1,3, Rocco Liguori1,3, Raffaele Lodi1,2, and Caterina Tonon1,2
1Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, 2Functional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, 3Clinica Neurologica Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, 4Department of Medicine and Surgery, University of Parma, Parma, Italy, 5Department for Life Quality Sciences, University of Bologna, Bologna, Italy

Keywords: Other Neurodegeneration, Quantitative Susceptibility mapping, Myotonic Dystrophy type 1

Motivation: QSM is a valuable tool for investigating neurodegenerative conditions, including DM1, a genetic multisystem disorder affecting the central nervous system. 

Goal(s): The objective of this research is to identify biomarkers of clinical impairment by exploring magnetic susceptibility in sub-cortical areas of DM1 brains. 

Approach: We developed an automated pipeline for segmenting various structures and their sub-units. DM1 susceptibility values were compared to healthy controls and correlated with clinical and laboratory data. 

Results: Thalamus and brainstem were identified as key structures, showing increased iron concentration and correlation with disability and polysomnography scores, contributing to a comprehensive understanding of DM1 and its symptomathology. 

Impact: Examining iron accumulation in sub-cortical structures through QSM contributes to a complete understanding of DM1 as a neurodegenerative disorder.  Thalamus and brainstem, crucial in autonomic functions, exhibit alterations and correlations with clinical measurements, suggesting central origins of DM1 symptomatology.

17:210668.
Brain arterial remodeling and incident dementia: the Atherosclerosis Risk in Communities (ARIC) Study
Sile Wang1, Melissa Caughey2, Ziyang Xu1, Xinwei Zhou1, and Ye Qiao1
1Deptartment of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Deptartment of Biomedical Engineering, University of North Carolina & North Carolina State University, Chapel Hill, NC, United States

Keywords: Dementia, Blood vessels, MRA

Motivation: We aimed to address the gap in understanding the neurovascular contributions to dementia risk in a US community-based study, recognizing the need to consider arterial geometry factors and cerebral small vessel disease (CSVD).

Goal(s): Our study sought to investigate the relationship between brain arterial remodeling and incident dementia risk, focusing on how arterial geometry and CSVD factor into this complex equation.

Approach: Our approaches involved analyzing data from a US community-based study to assess the impact of arterial remodeling, arterial geometry, and CSVD on dementia risk.

Results: Our study's core findings indicate an increased risk of incident dementia associated with brain arterial remodeling.

Impact: Our model is promising for the prediction of cognitive decline and dementia diagnosis based on the MRA measurements.

17:330669.
Brain CSF clearance measured by phase-contrast MRI and dynamic 18F-MK-6240 PET in Alzheimer's disease
Liangdong Zhou1, Gloria C Chiang1, Xiuyuan H Wang1, Pan Liu2, Ilhami Kovanlikaya1, Olivier Baledent2, Mony J de Leon1, and Yi Li1
1Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 2Amiens Picardy University Hospital, Amiens, France

Keywords: Neurofluids, Alzheimer's Disease

Motivation: Beta-amyloid (Aβ) in Alzheimer’s disease (AD) is caused by decreased glymphatic clearance function. As the main source of CSF in glymphatic system, the mechanism of CSF dynamic in ventricle system is of great importance.

Goal(s): Use dynamic 18F-MK-6240 PET and PC-MRI to study the relationship of CSF clearance in lateral ventricle (LV) and aqueduct.

Approach: CSF turnover rate in LV is derived from dynamic 18F-MK-6240 PET. Aqueduct parameters were calculated using PC-MRI data. Linear regression analysis was performed between PET and PC-MRI measurements.

Results: The CSF clearance measurements from both PET and MRI are consistent and show diagnostic group difference. 

Impact: 18F-MK-6240 PET derived CSF turnover rate and phase-contrast MRI produced aqueduct CSF measurements are highly correlated. The data reveals diagnostic group difference after controlling for age and sex, indicating that the decreased CSF clearance is associated with Alzheimer’s disease.