| 15:45 | | Introduction |
| 15:57 | 0632.
 | High-Resolution Oblique Coronal MRI with Optimal Flexed-Knee Angle for Anterior Cruciate Ligament Tear Diagnosis Yunjie Liao1, Can Chen1, Xiao Liu1, Qi Liang1, Song Peng1, Peng Wu2, Lu Han2, and Pengzhi Hu1
1Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, China, 2Clinical & Technical Support, Philips Healthcare, Shanghai, China Keywords: Whole Joint, MSK Motivation: Anterior cruciate ligament (ACL) injuries are prevalent in the realm of knee injuries. Conventional MRI methodologies employed for diagnosing ACL tears exhibit low accuracy. Goal(s): Evaluate the diagnostic efficacy of high-resolution coronal MRI performed at an optimal flexion angle specifically for ACL tears. Approach: Healthy volunteers and patients are scanned to find the optimal flexion angle and compare the image quality with traditional extended-knee positioning approach. Results: The implementation of high-resolution coronal imaging at the ideal flexion angle (30 degrees) has the potential to enhance ACL visualization and improve diagnostic accuracy when compared with conventional techniques. Impact: The utilization of high-resolution coronal imaging at the optimal flexion angle (30 degrees) demonstrated a substantial enhancement in the visualization of the anterior cruciate ligament (ACL), resulting in a notable improvement in diagnostic accuracy as compared to conventional techniques. |
| 16:09 | 0633.
 | Association of Patella Bone Shape and MR-Diagnosed Patellar Tendinopathy with Patellar Cartilage T2/T1ρ in Elite Basketball Players Andrew M. Schmidt1, Elka B Rubin1, Mackenzie Little1,2, Madison George3, Hayden Zheng4, Katherine Young1, Arjun D. Desai1,5,6, Feliks Kogan1, Sharmila Majumdar7, Hollis G Potter8, Garry E. Gold1,3, and Anthony A. Gatti1
1Radiology, Stanford University, Stanford, CA, United States, 2University of Sydney, Sydney, Australia, 3Bioengineering, Stanford University, Stanford, CA, United States, 4Human Biology, Stanford University, Stanford, CA, United States, 5Electrical Engineering, Stanford University, Stanford, CA, United States, 6Computer Science, Stanford University, Stanford, CA, United States, 7Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 8Hospital for Special Surgery, New York, NY, United States Keywords: Tendon/Ligament, Tendon/Ligament, Bone shape, T2 mapping, T1ρ mapping Motivation: Patellar tendinopathy (PT) is a common injury in basketball that can lead to early retirement. Basketball influences bone shape and cartilage composition, yet the association between these factors and PT is unknown. Goal(s): We examined the association between PT, bone shape, and patellar cartilage composition in collegiate basketball players. Approach: We developed a measure of bone shape indicative of PT and investigated whether PT-associated bone shape is associated with patellar cartilage T2/T1ρ. Results: We effectively separated grades of PT using bone shape and identified bone shape features associated with PT. We found patellar cartilage composition is independent of PT and bone shape.
Impact: We developed a measure to identify varying grades of PT based on bone shape in collegiate basketball players. Future work will determine the association of our PT-bone shape score with MR-identifiable measures to identify athlete specific PT risk factors. |
| 16:21 | 0634.
 | Quantitative analysis of induced tendon degeneration using magic angle insensitive ultra-short echo time magnetization transfer Georg C Feuerriegel1, Adrian A Marth1,2, Sophia S Goller1, Monika Hilbe3, Reto Sutter1, and Stefan Sommer4,5
1Department of Radiology, Balgrist University Hospital, Zurich, Switzerland, 2Swiss Center for Musculoskeletal Imaging, Balgrist Campus, Zurich, Switzerland, 3Institute of Veterinary Pathology, University of Zurich, Zurich, Switzerland, 4Swiss Center for Musculoskeletal Imaging (SCMI), Balgrist Campus, Zurich, Switzerland, 5Advanced Clinical Imaging Technology (ACIT), Siemens Healthineers International AG, Zurich, Switzerland Keywords: Tendon/Ligament, Tendon/Ligament Motivation: Ultra-short echo time (UTE) imaging combined with magnetization transfer (MT) allows for magic angle effects (MAE)-insensitive quantification of short T2 tissues, but clinically feasible applications are rare. Goal(s): The objectives of this study were to qualitatively and quantitatively assess changes in bovine flexor tendons before and after collagen degradation. Approach: 3D UTE MT imaging was compared to UTE T2* mapping at 0°, 27°, 55° and 90° relative to the B0 field within a clinically feasible acquisition time. Results: Compared to UTE T2* mapping, UTE MT imaging was significantly less affected by the MAE and demonstrated a better performance in differentiating partial tendon tears. Impact: UTE MT imaging is a reliable and reproducible method for quantifying tendon degeneration that is robust to the magic angel effect, acquired within a clinically feasible scan time, and could therefore be a useful tool in the diagnosis of tendinopathies. |
| 16:33 | 0635.
 | Importance of ACL substructure composition for quantitative analysis using UTE Maik Rothe1,2, Klaus Bohndorf1, Richard Brill1, Walter Alexander Wohlgemuth1,2, and Alexander Gussew1,2
1Medical Physics Group, University Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Halle (Saale), Germany, 2Halle MR Imaging Core Facility, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany Keywords: Tendon/Ligament, Quantitative Imaging Motivation: Quantitative MR-imaging of ligaments needs special approaches like ultra-short echo-time (UTE) imaging. Most quantitative studies of the anterior cruciate ligament (ACL) regard it as a uniform structure and do not consider differences in ligament composition at different anatomical positions. Goal(s): This study is aimed to use UTE to evaluate anatomical position specific T1 and T2* parameters of the ACL. Approach: The region specific ACL T1 and T2* values of 10 healthy volunteers were investigated by quantitative UTE mapping. Results: Quantitative mapping revealed that T1 and T2* values decrease from the distal to the proximal ACL endings, due to different fractions of free water. Impact: This study
reveals that the anterior cruciate ligament (ACL) shows severe differences in
quantitative values between its proximal and distal ends. The ACL region plays
an important role in quantitative analysis and should be considered for
assessments of pathologies. |
| 16:45 | 0636.
 | Articular Cartilage 3D T2* Mapping at 7 Tesla in Patients with Medial Meniscus Posterior Root Tears Karsten Knutsen1, Abdul Wahed Kajabi1, Stefan Zbyn 2, Collin Steinberger 3, Luke Tollefson 4, Jesse Smith 1,5, Takashi Takahashi 1, Gregor Metzger 1, Robert LaPrade4, and Jutta Ellermann1
1CMRR/Radiology, University of Minnesota, Minneapolis, MN, United States, 2Biomedical Engineering, Lemer Research Institute, Cleveland Clinic, Cleveland, OH, United States, 3Colby College, Waterville, ME, United States, 4Twin Cities Orthopedics, Edina, MN, United States, 5Radiology, Ohio State University, Columbus, OH, United States Keywords: Cartilage, Cartilage, Osteoarthritis Motivation: Meniscal root tears are increasingly recognised as the ‘root cause’ of osteoarthritis with articular cartilage loss as the hallmark of the disease. Goal(s): Utilising SNR gains at 7T UHF MRI to detect early changes in cartilage composition. Approach: Compare high resolution quantitative cartilage 3D T2* relaxation times at 7T in patients with arthroscopically confirmed medial meniscal posterior root tears (MMPRT’s) to matched controls. Results: Prolonged T2* relaxation times were found in the weight bearing medial and lateral cartilage of the femur in patients with meniscal tears, when compared with controls. No changes were seen in the tibial cartilage. Impact: Identifying early cartilage degeneration using high resolution T2* at 7 Tesla could inform timely treatments, such as prompt meniscal repair, potentially preventing the onset of osteoarthritis. |
| 16:57 | 0637.
 | Quantitative UTE Imaging of Zonal Difference in Meniscus Arya Suprana1,2, Melissa Lou Silva2, Marco Toto-Brocchi2, Bhavsimran Malhi2, Jiyo Athertya2, James Lo1,2, Soo Hyun Shin2, Nicole Le1,3, Eric Y Chang2,3, Jiang Du1,2,3, and Yajun Ma2
1Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, San Diego, CA, United States, 2Department of Radiology, University of California, San Diego, San Diego, CA, United States, 3Radiology Service, Veterans Affairs San Diego Health Care System, San Diego, CA, United States Keywords: Quantitative Imaging, Cartilage, Meniscus Motivation: Quantitative MR imaging techniques could reveal compositional differences between red and white zones in menisci. Unfortunately, this type of analysis may not be possible using conventional sequences due to the rapid signal decay of menisci. Goal(s): The study aimed to investigate whether quantitative UTE imaging techniques could detect the zonal difference between the red and white zones in menisci. Approach: UTE imaging techniques, including UTE-T1, UTE-MT modeling, UTE-AdiabT1ρ, and UTE-T2*, were used to assess menisci in vivo quantitatively. Results: T1, MMF, and T2* values in the red zone are significantly lower than those in the white zone. Impact: Our qUTE MRI techniques
enable a quantitative, zonal, and compositional analysis of menisci in vivo,
which is valuable in helping understand the role of menisci in the pathogenesis
of complex diseases such as osteoarthritis. |
| 17:09 | 0638.
 | Clinical evaluation of spine disorders using high contrast cartilaginous endplate imaging Jiyo S Athertya1, Sheronda Statum 1, Xiaojun Chen1, Saeed Jerban1, Christine B Chung1,2, Jiang Du1,2,3, Eric Y Chang1,2, and Yajun Ma1
1UCSD, San Diego, CA, United States, 2Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States, 3Dept of Bioengineering, UCSD, San Diego, CA, United States Keywords: Other Musculoskeletal, MSK Motivation: Lower back pain is a common cause of ailment driven by disc degeneration and endplate defects. Imaging the CEP region would increase the diagnostic accuracy of early detection. Goal(s): To develop an optimized sequence to image the CEP that is readily translatable to clinical settings. Approach: The clinically available 3D FS-SPGR sequence was optimized and applied to image the CEP with high contrast for both asymptomatic and symptomatic subjects. Results: The optimized 3D FS-SPGR sequence with T1-weighting can delineate the CEP regions with high contrast and reveal irregularities that are not visible on routinely used protocols. Impact: The fast T1-weighted 3D FS-SPGR sequence can be readily implemented on clinical scanners, used to highlight the CEP, and shows promise for the detection of intervertebral disc abnormalities. |
| 17:21 | 0639.
 | Can MR only IR-UTE based BoneView imaging, along with routine MRI, be used to exclude sacroiliac joint (SIJ) pathologies without the need for X-Ray? Sharmila David1, Monica Gunasingh2, Chirath Sulalith1, Aruna Pallewatte1, Narayana Krishna Rolla2, Indrajit Saha3, and Tejas Shah2
1National Hospitals of Sri Lanka, Colombo, Sri Lanka, 2Philips, Bangalore, India, 3Philips, Gurugram, India Keywords: Bone, Bone, UTE, MSK Motivation: For a comprehensive diagnostic imaging investigation of SIJ, neither plain radiographs alone nor MRI alone provide sufficient specificity and sensitivity for accurate diagnosis of traumatic and/or non-traumatic sources of SIJ dysfunction. Goal(s): Our goal is to show that using UTE based BoneView imaging technique, we can sufficiently detect enough structural radiological features of SIJ in non-pathological cases. Approach: 24 patients with non-pathological SIJ were recruited for this study and inter-reader as well as inter modality agreement was computed based on a likert scale by two radiologists. Results: There was high inter reader agreement as well as inter modality agreement. Impact: MR only (IR-UTE based BoneView + routine MR) can be used to exclude patients
with pathological SIJs and further investigation is necessary to extend the findings
further to pathological cases as well. |
| 17:33 | 0640.
 | Quantitative 3D T2* Mapping of Meniscus Before and After Meniscal Root Repair at 7 Tesla Abdul Wahed Kajabi1,2, Stefan Zbyn3, Collin Steinberger1, Jesse Smith4, Karsten Knutsen1, Luke Tollefson5, Gregor Metzger1, Rob LaPrade5, and Jutta Ellermann1,2
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 3Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States, 4Diagnostic Radiology, Oregon Health & Science University, Portland, OR, United States, 5Twin Cities Orthopedics, Minneapolis, MN, United States Keywords: Other Musculoskeletal, MSK, Meniscus Motivation: Meniscal tears are a significant cause of osteoarthritis, and failure rate of meniscal repair remains high. MRI assessment of meniscus at 7T provides high signal-to-noise ratio and allows 3D evaluation of the tissue. Goal(s): Investigate and follow-up meniscal tissue integrity in pre- and post-repair patients. Approach: Quantitative 3D T2* mapping of the lateral and medial menisci in patients with posterior horn root tears in the medial meniscus and compare against matched controls. Results: Significantly increased T2* values were identified beyond the tear in both lateral and medial menisci of pre-repair patients and the values remained significantly elevated six months post-repair. Impact: Utilizing high-resolution 7 Tesla 3D T2* mapping, this study
quantitatively and longitudinally assesses meniscal tissue integrity of
patients who underwent medial meniscal posterior root tear repair, which has
significant impact on management and standard of care for the patients. |