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| 5085. | Efficacy of gadopiclenol in contrast-enhanced MRI of the breast: a post-hoc analysis. Christiane Kuhl1 and Alex Merkulov2
1Department of Diagnostic and Interventional Radiology, Aachen University Hospital, Aachen, Germany, 2University of Connecticut Health Center, Farmington, CT, United States Keywords: Breast, Breast, gadopiclenol; MRI; breast Motivation: Gadolinium dose reduction while maintaining MRI diagnostic efficacy is crucial. Goal(s): Compare gadopiclenol (0.05 mmol/kg) and gadobutrol (0.1 mmol/kg) in breast MRI. Approach: Post-hoc analysis on 70 patients with breast lesions from the PROMISE phase III study.
Lesion visualization was qualitatively (border delineation, internal morphology, contrast enhancement) and quantitatively (enhancement percentage [E%], lesion-to-background ratio [LBR]) evaluated by three blinded readers. Three additional readers assessed diagnostic preference. Results: Gadopiclenol was non-inferior to gadobutrol for all qualitative visualization parameters.
E% was higher with gadopiclenol, while LBR was similar between the two GBCAs.
Readers had in most cases no preference between images with the two GBCAs. Impact: Gadopiclenol at half the gadolinium dose compared
to current GBCAs can be particularly beneficial in patients receiving multiple
lifetime doses, such as high-risk women undergoing breast cancer screening. |
| 5086.
 | Comparative Quantitative Analysis in Ultrafast DCE Breast MRI: Population-Based Versus Individual Arterial Input Functions Tianwen Xie1,2, Qiufeng Zhao3, Caixia Fu4, Grimm Robert5, Marcel Dominik Nickel5, Weijun Peng1,2, and Yajia Gu1,2
1Radiology, Fudan University Shanghai Cancer Center, Shanghai, China, 2Oncology, Shanghai Medical College, Fudan University, Shanghai, China, 3Radiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, 4MR Applications Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, 5MR Application Predevelopment, Siemens Healthineers AG, Erlangen, Germany Keywords: Breast, Breast, Cancer Motivation: CAIPIRINHA-Dixon-TWIST-VIBE (CDTV) ultrafast dynamic contrast-enhanced MRI helps in characterizing breast cancer. Goal(s): However, no study has compared the accuracies of quantitative analysis using population-based arterial input function (P-AIF) and individual AIF (I-AIF) for diagnosing breast cancer. Approach: This study aimed to evaluate and compare the diagnostic accuracies of the inline quantitative analysis with P-AIF and I-AIF in diagnosing breast cancer. Results: It demonstrated a similarity in the quantitative analysis using P-AIF from CDTV and I-AIF in characterizing breast lesions. Impact: This study
transforms breast cancer diagnosis by validating P-AIF's efficiency in CDTV
MRI, offering prospects for streamlined, faster clinical application. It
encourages exploration into broader adaptations, aiming to provide
the accurate diagnosis and prognosis through expedited, accessible
testing methodologies. |
| 5087.
 | Lymphatic congestion in Fontan circulation demostrated by Gd-EOB-DTPA magnetic resonance lymphangiography Akihiro Inoue1, Michinobu Nagao1, Atsushi Yamamoto1, Reiko Sakai1, Satoru Morita1, Masami Yoneyama2, and Shuji Sakai1
1Tokyo Women's Medical University Hospital, Tokyo, Japan, 2Philips health care, Tokyo, Japan Keywords: Liver, Contrast Agent, Fontan circulation Motivation: In the Fontan circulation, congestive liver and lymphatic congestion caused by elevated central venous pressure become permanent. These complications (called as FALD) are considered poor prognostic factors as Fontan-associated liver disease, and hyperplasia of abnormal lymphatic pathway have often been seen. Goal(s): We attempt to depict abnormal lymphatic pathway using Gd-EOB-DTPA MRI and propose a classification of their severity. Approach: MR lymphangiography was scanned using three-dimensional heavily T2-weighted imaging with a 3-tesla scanner 10 minutes after Gd-EOB-DTPA administration. Patients were classified into the three grades. Results: MR lymphangiography with Gd-EOB-DTPA, demonstrates the localization and extent of the abnormal lymphatic pathways in Fontan circulation. Impact: In the Fontan circulation, the higer the lymphangiographic grade using MR lymphangiography with Gd-EOB-DTPA was, the more the adverse events was seen. The lymphangiographic grade is associated with the adverse events in Fontan-associated liver disease. |
| 5088.
 | Quantitative MRI of the Prostate with Age: T1 Relaxation, T2 Relaxation, Mean Diffusivity, and Volume Xiao Ma1, Peter Seres2, Adam Kinnaird3, Chris Fung2, Alan Wilman1,2, and Christian Beaulieu1,2
1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, 3Urology, University of Alberta, Edmonton, AB, Canada Keywords: Prostate, Aging Motivation: T1 relaxation, T2 relaxation, mean diffusivity (MD) and volume can offer valuable information about prostate tissue remodeling that may occur with cancer and aging. Goal(s): These age relationships are relevant for identification of cancer thresholds, but also provide insight on unique prostate zone changes with age. Approach: 74 normal volunteers aged 19-69 years were scanned. Results: T1, T2, MD and volume in the peripheral zone showed a positive quadratic association with age being mainly flat and then increasing after 45 years. In contrast, there were no such T1/T2/MD versus age correlations in the transition zone, despite a marked increase of volume with aging. Impact: Quantitative T1/T2 relaxation
and mean diffusivity demonstrate microstructural
changes of the prostate, particularly in the peripheral zone and not the
transition zone, with typical aging (19-69 years) which may provide a
‘normative’ benchmark for tumor identification. |
| 5089.
 | Unsupervised Super Resolution of Diffusion Weighted Imaging Guided by High-Resolution Cross-Modality Prior Zengtian Deng1,2, Haoran Sun1,2, Lixia Wang1, Timothy J. Daskivich3, Hyung Kim3, Yibin Xie1, and Debiao Li1,2
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, 3Minimal Invasive Urology, Cedars-Sinai Medical Center, Los Angeles, CA, United States Keywords: Prostate, Prostate, Super Resolution, Deep Learning, Unsupervised Motivation: Existing supervised super-resolution is challenging for Diffusion Weighted Imaging(DWI) due to acquisition. However, the feature of T2 weighted imaging(T2w) could be utilized as a prior for unsupervised training. Goal(s): To develop unsupervised super-resolution on DWI with the aid of high-resolution T2w images. Approach: A UNet architecture is designed to perform same-resolution domain adaptation. During inference, the high frequency feature of the T2w images are used to fuse with the low frequency feature of original DWI in k-space to reconstruct high-resolution DWI. Results: Our result shows improved SSIM score verified by paired student t-test. Our direct inference on HR DWI also exhibits improved sharpness. Impact: This pilot work demonstrated that HR images
(T2w) can be domain-adapted to provide high frequency prior to unsupervised super-resolution
tasks using computationally efficient DL models. |
| 5090.
 | Virtual gadolinium contrast enhancement MRI using deep learning GAN in rectal cancer: a proof-of-concept two-center study Xinyi Gao1 and Dening Ma2
1Department of Radiology, Zhejiang Cancer Hospital, Hangzhou, China, 2Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou, China Keywords: Pelvis, Safety, rectal cancer, GBCAs, deep learning Motivation: It would be clinically beneficial if GBCAs enhancement could be accurately synthesized without any GBCAs administration though AI. Goal(s): To evaluate the feasibility of deep learning in synthesizing VTE based on noncontrast rectal cancer MRIs obtained without the use of gadolinium. Approach: Deep learning networks were trained and validated on nonenhanced conventional pelvic MRI (T1WI, T2WI, DWI-ADC) using GAN. MRI scans included 697 rectal cancer patients from two hospitals. Results: Quantitative and qualitative evaluation of three-channel VTE was significantly better than that of two-channel and one-channel (P＜0.001). The T staging accuracy of VTE was comparable with that of RTE. Impact: VTE synthesized
by deep learning based on noncontrast MRI can overcome the limitations of RTE and aid in the clinical diagnosis and
management of rectal cancer as a noninvasive, save, affordable and time-saving method
that does not require GBCAs. |
| 5091.
 | Restoration of Bi-contrast Whole Body MRI for Discontinuous Intensity Nonuniformities Ismini Papageorgiou1,2, Ansgar Malich1, Lorenz Damian Rossknecht1, and Stathis Hadjidemetriou3
1Institute for Radiology, South Harz Hospital Nordhausen, Nordhausen, Germany, 2Institute for Diagnostic and Interventional Radiology, University Medicine of Jena, Jena, Germany, 3Department of Information Technologies, University of Limassol, Limassol, Cyprus Keywords: Screening, Artifacts, bone metastases, signal restoration, cancer screening Motivation: Whole-body MRI, a screening tool for bone metastatic disease, uses parallel coil imaging to cover a large Field of View. Signal inhomogeneities at the coil junction points create jump discontinuities in the signal intensity with a negative effect on serial image stitching. Goal(s): To correct for signal jump discontinuities between coils using computer vision. Approach: We engaged piecewise smooth intensity nonuniformities fields using anisotropic diffusion and quantified for improvement in image entropy (H). Results: Our algorithm smoothens the signal intensity between parallel coils by 8% based on entropy metrics. Impact: We
implement a novel non-parametric methodology with piecewise
smoothness to improve intensity non-uniformities between parallel
coil images in whole-body MRI (WB-MRI). Optimized whole-body stitched
images render WB-MRI into a one-stop-shop staging method. |
| 5092.
 | Multiparametric MRI for Tumor Restaging of Locally Advanced Gastric Cancer Following Neoadjuvant Therapy Ya-jun Hou1, Zi-tong Sang1, Qiong Li1, Wei-yue Xu1, Dominik Nickel2, Yi-Cheng Hsu3, and Xi-sheng Liu1
1Department of Radiology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China, 2MR Application Predevelopment, Siemens Healthineers AG, Erlangen, Germany, 3MR Research Collaboration Team, Siemens Healthineers Ltd., Shanghai, China Keywords: Digestive, Diffusion/other diffusion imaging techniques, DCE Motivation: Accurate presurgical restaging of tumor invasion depth (ycT stage) is critical to determining appropriate therapies and evaluating outcomes for locally advanced gastric cancer after neoadjuvant therapy. Despite the reported advantages of computed tomography, its accuracy is low, with often heterogeneous results. Goal(s): We tested the performance of multiparametric MRI for gastric cancer tumor restaging. Approach: Three radiologists evaluated ycT stage based on T2WI, DWI, ZOOMit DWI, and XD-VIBE DCE sequences. Results: Multiparametric MRI provides accurate differentiation of restaging after neoadjuvant therapy. ZOOMit DWI and XD-VIBE achieved higher accuracy than did conventional T2WI and DWI in assessing ycT stage. Impact: Multiparametric MRI is expected to improve the accuracy of restaging gastric cancer after neoadjuvant therapy and guide decision making for clinical treatment. |
| 5093.
 | Multiparametric MRI as a Diagnostic Tool for Metabolic Dysfunction-Associated Steatotic Liver Disease Nienke P.M. Wassenaar1,2, Koen C. van Son3,4,5, Marian A. Troelstra1, Stan Driessen3,4, Anne Linde Mak3,4, Elizabeth Shumbayawonda6, Max Nieuwdorp3,4, Joanne Verheij4,7, Aart J. Nederveen1, Adriaan G. Holleboom3,4, and Oliver J. Gurney-Champion1,2
1Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands, 2Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands, 3Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands, 4Amsterdam Gastroenterology Endocrinology Metabolism (AGEM) Institute, Amsterdam, Netherlands, 5Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, Netherlands, 6Perspectum Ltd., Oxford, United Kingdom, 7Pathology, Amsterdam University Medical Centers, Amsterdam, Netherlands Keywords: Liver, Quantitative Imaging, Biomarkers, Diagnosis, Elastography, IVIM, Liver Motivation: The reference standard for diagnosing Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD) is invasive liver biopsy. There is a need for non-invasive diagnostic methods to assess MASLD. Goal(s): The goal was to determine if multiparametric MRI, including cT1-mapping, MR elastography, intravoxel incoherent motion diffusion-weighted MRI and proton-density fat fraction, can effectively diagnose metabolic-dysfunction-associated steatohepatitis (MASH). Approach: The diagnostic potential of multiparametric MRI parameters was assessed in 75 MASLD patients from the ongoing Amsterdam MASLD cohort study ANCHOR. Results: Results demonstrated that multiparametric MRI can play a role in diagnosing MASLD stages, providing an alternative non-invasive diagnostic method to liver biopsies. Impact: This research enables non-invasive diagnosis of Metabolic-Dysfunction-Associated Steatotic Liver Disease by combining cT1, MRE stiffness, and blood marker AST. This provides an alternative to liver biopsy, allowing assessment of the entire liver, which could significantly impact clinical practice and trials. |
| 5094.
 | Cervical Cancer and Paracancerous Tissue ATPw combined with DWI to predict Parametrial infiltration: An Preliminary Study Lianze Du1, Qinghe Han1, Qinghai Yuan1, and Mengdi Zhang1
1The Second Hospital of Jilin University, Changchun, China Keywords: fMRI Analysis, fMRI Motivation: Cervical cancer(CC) is one of the most common gynecological malignancies. Parametrial infiltration (PMI) is considered a decisive factor in the treatment of patients with CC. Goal(s): This study aimed to investigate the potential of Amide proton transfer-weighted (APTw) in predicting PMI of CC, and to further evaluate whether the APTw parameters of paracancerous tissue can add diagnostic value to diffusion-weighted MRI of CC. Approach: 81 participants underwent pelvic MRI , including APTw MRI ,and takes measurements. Results: The results showed that the APTw values ,especially in paracancerous tissues, could be used to efficiently distinguish PMI of cervical cancer. Impact: APTw values ,especially in paracancerous tissues, could be used to efficiently distinguish PMI of cervical cancer. which can provide additional information to improve the results of diffusion-weighted MRI, thereby assisting further clinical decision-making and improving patient prognosis. |
| 5095.
 | Evaluation of kidney injury using ASL and BOLD MRI: an experimental study in rats with CCl4-induced liver cirrhosis Jiaming Qin1, Shuangshuang Xie2, Yongquan Yu3, Yumeng Zhao4, Jiaqi Yang5, Caixin Qiu6, Xiaotian Li7, Cheng Zhang5, Zhandong Hu6, Jinxia Zhu8, Bernd Kuehn9, and Wen Shen6
1The School of Medicine, Nankai Univeisity, Tianjin, China, 2Department of Radiology, Tianjin First Central Hospital, Tianjin, China, 3Weihai Central Hospital, Weihai, China, 4Department of Radiology, Nankai Univeisity, Tianjin, China, 5Tianjin Medical University, Tianjin, China, 6Tianjin First Central Hospital, Tianjin, China, 7Nankai Univeisity, Tianjin, China, 8Siemens Healthineers, Beijing, China, 9Siemens Healthineers AG, Erlangen, Germany Keywords: fMRI Analysis, Animals Motivation: Noninvasive and sensitive methods for assessing chronic liver disease-associated kidney injury are needed in clinics. Goal(s): We investigated the potential of arterial spin labeling (ASL) and blood oxygenation level-dependent (BOLD) MRI for diagnosing and evaluating chronic liver disease-associated kidney injury progression. Approach: We observed the renal blood flow (RBF) and T2* changes in rats with CCl4-induced chronic liver disease and compared imaging, pathological, and biochemical indicators at different time points. Results: During chronic liver disease development in rats, RBF and T2* gradually decreased, and ASL and BOLD MRI were more sensitive than serum creatinine in diagnosing renal injury. Impact: Compared with serum creatinine, ASL and BOLD MRI exhibited more sensitive diagnostic value for liver cirrhosis-associated renal injury, providing a noninvasive and reliable method for monitoring kidney injury in patients with chronic liver disease. |