ISSN# 1545-4428 | Published date: 19 April, 2024
You must be logged in to view entire program, abstracts, and syllabi
At-A-Glance Session Detail
   
Cardiovascular Pathology in 3D, 4D & Beyond
Traditional Poster
Tuesday, 07 May 2024
Gather.town Space:   Room: Exhibition Hall (Hall 403)
09:15 -  10:15
Session Number: T-05
No CME/CE Credit

4910.
The effect of valve annulus tracking on mitral valve regurgitation: A comparative in vitro study between ultrasound and 4D flow MRI
Minseong Kwon1, Juyeon Lee2, Sungho Park3,4, and Hyungkyu Huh1
1Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea, Republic of, 2Ulsan university, Ulsan, Korea, Republic of, 3Department of Radiology, Children's Hospital Colorado, University-Campus, Aurora, CO, United States, 4Institute of Medical Devices, Kangwon National University, Chuncheon, Korea, Republic of

Keywords: Flow, Cardiovascular

Motivation: Mitral valve regurgitation (MVR) is the most common heart valve diseases, but accurate quantification of MVR has been limited due to the dynamic motion of valves. 

Goal(s): We hypothesize that volumetric flow information by 4D flow MRI with the compensation of MV motion could address this challenge.

Approach: MVR was measured using a simulated-in vitro model by comparing with actual flow from pump, ultrasound, and 4D flow MRI with/without a mitral registration algorithm.

Results: PISA method overestimated MVR. 4D flow MRI without algorithm seems to have similar the amount of actual MVR, while it decreased with employing algorithm.
 

Impact: Accurate quantification of regurgitation plays an important role for diagnosing patients with valvular diseases. This study would have a chance to measure accurate MVR quantification and quantify complex intracardiac blood flow using 4D flow MRI.

4911.
4D flow CMR-derived left ventricular hemodynamic indicators for evaluating heart failure with reduced ejection fraction patients
Rui Wang1, Xinyan Tao 1, Jianxiu Lian2, and Lei Xu1
1Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, 2Philips Healthcare, Beijing, China

Keywords: Heart Failure, Cardiovascular

Motivation: Heart failure is a clinical syndrome in which the heart is unable to pump blood efficiently, and Heart Failure with Reduced Ejection Fraction (HFrEF) with the left ventricular ejection fraction (LVEF) < 40% serve as high morbidity and mortality.

Goal(s): The aim of this study is to investigate the hemodynamic environment in left ventricle of different phases.

Approach: 4D flow technology could offer non-invasive method for quantifying the alternatives of intracardiac blood flow components in HFrEF with and without MACE.

Results: Results showed reduced DF-KEiESV, DEF-KEiESV, higher RVo and peak E-wave RVo-KEiEDV were confirmed in MACE+ group when compared with MACE- group.

Impact: The hemodynamic analysis in HFrEF when compared patients with and without MACE illustrated significant alternative of intracardiac blood flow components by using 4D flow technology, which could offer valuable insight for further assessment and treatment planning. 

4912.
Predictive value of left atrial and left ventricular strain for sudden cardiac death risk in hypertrophic cardiomyopathy by feature-tracking CMR
Xinyu Zhu1, Pengfei Liu1, Ying Shi1, Jianxiu Lian2, Lulu Li1, Honghu Shen1, and Haishan Wu1
1the First Affiliated Hospital of Harbin Medical University, Harbin, China, 2Philips Healthcare, Beijing, China

Keywords: Myocardium, Cardiomyopathy

Motivation: The risk stratification for implantable cardioverter-defibrillators (ICD) placement in high-risk patients with hypertrophic cardiomyopathy (HCM) has challenges.

Goal(s): The aim of this study is to investigate the connection between left atrial and left ventricular strain and sudden cardiac death (SCD) risk stratification by feature-tracking CMR.

Approach: All patients were satisfied by the 2020 AHA/ACC HCM Risk-SCD model with feature-tracking CMR for assessing left atrial and left ventricular strain.

Results: Results demonstrated that both left atrial and left ventricular strain show obvious attenuation in high-risk group than low-risk group. LVGRS+LARS combined model exhibited a superior diagnostic value for identifying high-risk SCD.
 

Impact: The LVGRS+LARS combined model could provide additional predictive value for improving SCD risk stratification in clinical practice, which may provide vital insights into the judicious clinical utilization of ICD to reduce SCD in HCM.

4913.
Prognostic Value of Right Ventricular 3D Trabecular Complexity in Arrhythmogenic right ventricular cardiomyopathy
Jin-Yu Zheng1, Bing-Hua chen1, Chong-Wen Wu1, Rui Wu1, Dong-Aolei An1, Ruo-Yang Shi1, Jingyu Xie2, Shan-shan Jiang3, Lian-Ming Wu1, and Lei Zhao4
1RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2Philips Healthcare, shanghai, China, 3Philips Healthcare, Xi'an, Shaanxi, China, 4Beijing Anzhen Hospital, Capital Medical University, Beijing, China

Keywords: Myocardium, Cardiovascular

Motivation: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by progressive myocardial fibro-fatty infiltration accompanied by trabecular disarray. The prognostic value of trabecular disorder assessed by three-dimensional (3D) fractal dimension (FD) measurement is unclear.

Goal(s): To investigate the prognostic value of 3D right ventricular trabecular complexity of ARVC.

Approach: Using cine images, trabecular complexity was measured with 3D fractal analysis to calculate 3D-FD in ARVC patients retrospectively. Cox regression analyses and Kaplan-Meier survival analysis were performed to identify the prognostic value of 3D-FD.

Results: RV 3D-FD was a significant risk predictor for MACE in ARVC and provided incremental prognostic value to conventional predictors.

Impact: Based on the results, we suggested  3D  RV trabecular complexity, derived from non-invasive imaging examination, as a new biomarker for early clinical therapy in medication and ICD implantation in order to moderate the onset of adverse endpoints in ARVC patients.

4914.
Good agreement of turbulent kinetic energy assessment by compressed sensing-accelerated 4D flow MRI in aortic stenosis patients
Sungho Park1,2,3, Ning Jin4, Dongyeop Han5, Bae Young Lee6, Minseong Kwon3, Jeong-Eun Yi7, and Hyungkyu Huh3
1Department of Radiology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 2Institute of Medical Devices, Kangwon National University, Chuncheon, Korea, Republic of, 3Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea, Republic of, 4Cardiovascular MR R&D, Siemens Medical Solutions, Cleveland, OH, United States, 5Siemens Healthineers Ltd., Seoul, Korea, Republic of, 6Department of Radiology, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, 7Division of Cardiology, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of

Keywords: Flow, Data Analysis, 4D flow MRI, Compressed sensing

Motivation: Compressed sensing (CS) acceleration has improved the clinical applicability of 4D flow MRI. However, but no studies have investigated turbulent kinetic energy (TKE) assessment using CS-accelerated 4D flow MRI.

Goal(s): This study aims to validate TKE assessment in CS 4D flow MRI compared to conventional 4D flow MRI.

Approach: The effect of CS acceleration on TKE assessment was evaluated by in vitro coarctation model. In addition, TKE assessment was further validated in healthy subjects and aortic stenosis (AS) patients.

Results: TKE parameters had good agreement in AS patients at the ascending aorta, while healthy subjects had significant differences.

Impact: TKE estimation has been limited due to asymmetric velocity encoding scheme, requiring additional MR scans. This study firstly validates the reliability of TKE using CS 4D flow with reduced scan time in AS patients.

4915.
Adiabatic T1rho-mapping of subacute myocardial ischemia with ultra-short echo time 3-D imaging in ex vivo mice
Iida Räty1, Antti Paajanen2, Mikko Nissi2, Sanna Kettunen1, Anna-Kaisa Ruotsalainen1, Svetlana Laidinen1, Seppo Ylä-Herttuala1, and Elias Ylä-Herttuala1
1A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 2Department of Technical Physics, University of Eastern Finland, Kuopio, Finland

Keywords: Myocardium, Quantitative Imaging, Ex vivo applications, High field MRI, Small animals, Ischemia, Preclinical imaging

Motivation: Conventional CMR techniques have many limitations, such as slowness and inability to provide contrast-agent free 3-D assessments of myocardium in the cardiac diseases.

Goal(s): The aim of this study is to develop a faster, high-resolution 3-D CMR imaging method for quantitative imaging of the myocardium after myocardial infarction (MI).

Approach: Mice hearts were imaged ex vivo 7 days after the factitious MI by using an ultra-short echo time 3-D T technique (MB-SWIFT-CS).

Results: The T relaxation times were elevated in the infarct area. The findings were validated by 2-D CMR maps and histopathology to confirm ischemia, edema, and fibrosis in the myocardium.

Impact: This study presents a quantitative ultra short echo time 3-D CMR method for ex vivo assessment of myocardium after factitious myocardial infarction in mice. The method allowed rapid comprehensive 3-D myocardial evaluation by utilizing compressed sensing and relaxation time mapping.  

4916.
Diffusion-weighted imaging of reperfused acute myocardial infarction: effect of intravenous gadolinium-based contrast agent administration
Shuguang Han1, Dan Wang1, Jiali Wang1, Lu Han2, Peng Wu2, Yongjun Cheng2, Chunfeng Hu1, and Kai Xu1
1Department of Radiology, The Afliated Hospital of Xuzhou Medical University, XUZHOU, China, 2Philips Healthcare, Shanghai, China, Shanghai, China

Keywords: Myocardium, Diffusion/other diffusion imaging techniques, acute myocardial infarction, reperfusion injury

Motivation: Cardiac diffusion-weighted(DW)imaging has proven to be an effective approach to explore ischemia reperfusion myocardium damage and inflammation induced by treatment after reperfusion.

Goal(s): The objective of this study was to investigate whether contrast agent (CA) administration significantly affects DWI in the evaluation of reperfused acute myocardial infarction.

Approach: The apparent diffusion coefficient (ADC) values,signal intensity(SI) and contrast-to-noise ratio(CNR) pre- and post-contrast were measured in the intramyocardial hemorrhage (IMH),edema area and remote regions, respectively. 

Results: The ADC values in IMH and edema area were not significantly changed between pre- and post-contrast (P>0.05), while the SI of remote myocardium was inhibited and CNRs were reduced.

Impact: To better assess ischemia reperfusion myocardium damage, DWI is recommended to perform as much as possible before the gadolinium-based contrast agent administration.

4917.
The clinical application of 5.0 T 3D TOF MRA in the imaging of AChA and related cerebrovascular diseases
Zhangzhu Li1, Mingyan Shang2, Min Fu3, Zhensong Wang3, Jianxian Liu3, Liang Yin3, Dan Yu4, and Jie Gan2
1Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, JINAN, China, 2Department of Radiology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China, 3Department of Radiology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, JINAN, China, 4United Imaging Research Institute of Intelligent Imaging, Beijing, People’s Republic of China, Beijing, China

Keywords: Vascular, Brain, magnetic resonance imaging; TOF MRA; Anterior choroidal artery AChA; 5.0 T

Motivation:  Improved cerebrovascular disease diagnosis requires enhanced imaging of the anterior choroidal artery (AChA).

Goal(s): To evaluate the effectiveness of a 5.0T ultra-high-field MR scanner for cerebrovascular imaging compared to traditional 3.0T scanners.

Approach: Retrospective analysis using 5.0T MR imaging to assess AChA visualization in patients with cerebrovascular complaints.

Results: The 5.0T scanner significantly outperformed the 3.0T in image quality and detail, providing superior AChA delineation, which is essential for diagnosing related cerebrovascular diseases.

Impact: The 5.0T MR imaging's superior visualization of AChA paves the way for better diagnosis and management of deep brain vascular diseases, potentially influencing treatment outcomes and advancing neurovascular research.  

4918.
Vulnerable plaques are associated with white matter hyperintensities: a finding on high-resolution vessel wall magnetic resonance imaging.
Jiayu Li1, Ying Shi1, Jianxiu Lian2, and Pengfei Liu1
1First Affiliated Hospital of Harbin Medical University, Harbin, China, 2Philips Healthcare, Beijing, China

Keywords: Atherosclerosis, Atherosclerosis

Motivation: Cerebral small vessel disease (CSVD) is a common disease in the elderly with uncertain causes. We wanted to explore whether intracerebral macrovascular disease is related to CSVD.

Goal(s): This study was to explore the relationship between atherosclerotic plaque characteristics and wall changes and white matter hyperintensities (WMH) associated with CSVD.

Approach: As a non-invasive technique, high-resolution vessel wall magnetic resonance imaging can display   vascular image and measure plaque parameters and vascular wall changes. Using the tools, the differences between WMH groups were analyzed.

Results: WMH was associated with unstable plaques. Age, wide distribution and significant enhancement were independent factors affecting WMH.

Impact: Unstable atherosclerotic plaque may cause CSVD, suggesting that clinicians should pay more attention to patients with ischemic stroke. The plaque vulnerability parameter may be a new index to evaluate the degree of WMH.