|
| 5032.
| Evaluation of bone marrow fat content and fatty acid composition using quantitative MRI combined with metabonomics in diabetic rabbits Tian Zhang1, Lei Hu1, Ziyan Fei1, Yufan Gao1, Yan Wang1, Yuchen Yan1, Weiyin Vivian Liu2, and Yunfei Zha1 1Renmin Hospital of Wuhan University, Wuhan, China, 2GE Healthcare, Beijing, China Keywords: Bone, Diabetes Motivation: Bone marrow is a key target for diabetes mellitus. Goal(s): Quantitative assessment of fat content in lumbar bone marrow and trabecular microstructural changes in alloxan-induced diabetics rabbits. Approach: Iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation sequence (IDEAL-IQ), micro computed tomography (Micro-CT), and gas chromatography-mass spectrometry (GC-MS) were employed. Results: IDEAL-IQ and GC-MS techniques are capable of detecting changes in fat content and variations in fatty acid composition during the early stages of diabetic bone marrow. Impact: The fat content and fatty acid composition in the bone marrow plays an important role in bone metabolism in diabetic patients. |
| 5033.
| T2 relaxometry of foot muscles in young patients with Charcot-Marie-Tooth disease: comparison between centres and scanner vendors Nick Zafeiropoulos1, Carolynne M Doherty1, Howard Paige2, Stephen Wastling1, Riccardo Zuccarino2,3, Evelin Milev4, Tina Banks4, Sachit Shah5, Katherine Stephens2, Tiffany Grider2, Shawna M Feely2, Peggy Nopoulos2, Mariola Skorupinska1, Menelaos Pipis1, Emma J Nicolaisen2, Amy McDowell1, Luke O'Donnell1, Alex M Rossor1, Laura Matilde1, Francesco Muntoni1, Tarek Yousry1, Daniel Thedens2, Jasper M Morrow1, Michael E Shy2, Mary M Reilly1, David Thomas1, and John Thornton1 1University College London, London, United Kingdom, 2University of Iowa, Iowa, IA, United States, 3Centro Clinico NeMO Trento, Trento, Italy, 4Great Ormond Street Hospital, London, United Kingdom, 5National Hospital for Neurology and Neurosurgery, London, United Kingdom Keywords: Muscle, Relaxometry, T2 mapping Motivation: Current clinical use of quantitative MRI biomarkers for the assessment of neuromuscular disease is limited by accuracy and reliability Goal(s): To develop a robust processing strategy for multi-vendor muscle-water T2 mapping (T2m) in foot muscle Approach: A multi-component CPMG extended phase graph signal model was used to determine T2m and apparent fat fraction (ffa) in fat-infiltrated foot muscle using maximum likelihood estimation Results: Stable estimates of foot muscle T2m and ffa were obtained in patients with Charcot-Marie-Tooth disease and healthy controls, at baseline and 1 year follow up. In patients, T2m and ffa were both elevated at each time point Impact: T2m and ffa obtained from
CPMG images using extended phase graph modelling and maximum likelihood
estimation may be sensitive measures of neuromuscular pathology |
| 5034.
| How temperature and immersion liquid affect the relaxation properties in articular cartilage samples? Olli Nykänen1,2, Iida Räty3, Henri Leskinen1, Nina Hänninen1,4, and Mikko J Nissi1 1Department of Technical Physics, University of Eastern Finland, Kuopio, Finland, 2Oulu University Hospital, Oulu, Finland, 3A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 4Imaging Center, Kuopio University Hospital, Kuopio, Finland Keywords: Cartilage, Cartilage Motivation: Preclinical measurement series of articular cartilage samples are often time-consuming. Thus, knowledge about changes in relaxation properties of cartilage during measurements and depending on the sample handling is important. Goal(s): To study the effect of storage temperature and immersion liquid on the relaxation properties of articular cartilage. Approach: T1, T2, and adiabatic T1rho relaxation times were measured for 28 cartilage-bone samples at five timepoints and analyzed by linear regression. Results: T1 and adiabatic T1rho relaxation times increased over time, while T2 varied. Immersion in phosphate-buffered saline instead of signal-free perfluoropolyether increased the relaxation times in superficial cartilage. Impact: The study increases understanding on how the relaxation properties within ex vivo cartilage samples change over time. The results obtained here should be considered when planning future studies utilizing such samples. |
| 5035.
| Per-voxel classification of Modic changes in conventional MRI Christian Waldenberg1,2, Harald Foss1, Hanna Hebelka3, Helena Brisby4, and Kerstin Lagerstrand1,2 1Department of Medical Radiation Sciences, University of Gothenburg, Gothenburg, Sweden, 2Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden, 3Department of Radiology, University of Gothenburg, Gothenburg, Sweden, 4Department of Orthopaedics, University of Gothenburg, Gothenburg, Sweden Keywords: Bone, Data Analysis, Spine Motivation: Modic Changes (MCs) are often heterogeneous and difficult to classify objectively. Hence, new diagnostic tools are required to improve MC classification. Goal(s): This study aims to develop a data-driven model for the classification of MC lesions on a per-lesion and per-voxel level from conventional MR images. Approach: Conventional MR images from 12 patients were used to create an MC classification model by fitting three multivariate normal distribution functions to the MRI MC data which was subsequently used for MC classification. Results: The model reached high accuracy (74-100%), enabling a detailed classification on a per-voxel level and longitudinal tracking of MC transitions. Impact: This study introduces a data-driven model for classifying Modic changes in vertebral bone marrow using MR images. The model achieves high accuracy, enabling detailed classification and tracking of Modic change transitions, potentially improving patient diagnosis and care. |
| 5036.
| The MOTION study – First quantitative muscle MRI results in a large cross-sectional cohort of healthy subjects Linda Heskamp1, Roosmarijn Brenninkmeijer2, Lara Schlaffke3, Bart Bartels2, and Martijn Froeling1 1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Child Development and Exercise Center, UMC Utrecht, Utrecht, Netherlands, 3Department of Neurology, BG-University Hospital Bergmannsheil gGmbH, Bochum, Germany Keywords: Muscle, Muscle, Quantitative Imaging Motivation: The overall aim of our ongoing study MOTION is to connect whole leg quantitative MRI (qMRI) and muscle structure to function and lifestyle in 162 healthy volunteers. Goal(s): Preliminary analysis of 31 subjects to identify potential covariates that may impact qMRI measurements. Approach: Muscle fat fraction (FF), mean diffusivity (MD), fractional anisotropy (FA) and T2water were determined in 20 muscles from tendon to tendon bilaterally, and related to age, gender, and body composition. Results: Muscle FF is higher in heavier subjects with more body fat. FA is lower and MD and volume are higher in larger subjects. T2water depends on age and gender. Impact: Accounting for covariates describing body composition (BMI, lean body mass and body fat mass) on top of gender and age is crucial for proper interpretation of quantitative muscle MRI in clinical studies on neuromuscular disease patients and healthy controls. |
| 5037.
| Water T2 mapping from low to high fat fraction values in lower limb skeletal muscles of different neuromuscular disorders Harmen Reyngoudt1, Pierre-Yves Baudin1, Ericky Caldas de Almeida Araujo1, and Benjamin Marty1 1NMR Laboratory, Neuromuscular Investigation Center, Institute of Myology, Paris, France Keywords: Muscle, Modelling, biomarkers, neuromuscular, water T2, fat fraction Motivation: Muscle water T2 is an interesting quantitative MRI biomarker in neuromuscular disorders but its interpretation is influenced by the presence of fat. Goal(s): We investigated how this water T2-fat relationship differed between nine different neuromuscular disorders. Approach: We looked at linear and 2nd degree polynomial fits, all obtained with the same 3-T system, sequence and post-processing pipeline. Results: Polynomial fitting describes the data better and the water T2-fat relationship needs to be interpreted in a disease-specific context, especially when there is a known inflammatory component and/or if water T2 is increased before the occurrence of any muscle fat replacement. Impact: The relationship between MRI biomarkers water T2,
reflecting active muscle damage, and fat fraction, reflecting disease
progression, should be interpreted in the context of the disease, whether or
not there is inflammation or extensive active muscle damage. |
| 5038.
| Feasibility of echo asymmetry and least squares estimation (IDEAL-IQ) in differentiation of atypical spinal hemangiomas from metastases Qizheng Wang1, Ke Xu1, Xiaoxi Ji1, and Ning Lang1 1Peking University Third Hospital, Beijing, China Keywords: Skeletal, Skeletal Motivation: It is common for patients with primary tumors to find abnormal signals in the spine, which may be initially reported as “metastases cannot be rule out”. For these cases, differential diagnosis has a significant impact on patient staging and management, which may result in misdiagnosis or additional imaging, ultimately biopsy, and unnecessary costs. Goal(s): To investigate chemical shift-encoded sequence (IDEAL-IQ) for differential diagnosis of spinal tumors. Approach: Single-center prospective study. Results: This work highlights the benefits of adding proton density fat fraction (PDFF) maps yield from IDEAL-IQ to improve diagnostic accuracy of spinal metastases and hemangiomas without contrast agents. Impact: IDEAL-IQ provides reliable
quantification of spinal tumor bone marrow infiltration pattern in clinical
settings, which is comparable to the quantitative parameters of DCE-MRI. It may
be a valuable tool for providing information for early differential diagnosis in
a non-invasive way. |
| 5039.
| Bone Imaging of the Knee Using delta UTE (𝛅UTE) and Field Echo Imaging Won C Bae1,2, Vadim Malis1, Yuichi Yamashita3, Anya Mesa1, Diana Vucevic1, and Mitsue Miyazaki1 1University of California, San Diego, La Jolla, CA, United States, 2VA San Diego Healthcare System, San Diego, CA, United States, 3Canon Medical Systems Corporation, Tochigi, Japan Keywords: Bone, Bone, UTE, Knee, Osteoarthritis Motivation: Bony structures of the human knee play import roles in the stability and normal function and show alterations in morphology with diseases such as osteoarthritis. Goal(s): Advance MR imaging of the bone. Approach: Three techniques utilizing delta ultrashort echo time (𝛅UTE), field echo (FE), and FE with deep learning reconstruction (DLR) with simple post-processing was developed to image knees of volunteers. SNR and CNR were determined. Results: We demonstrate that FE DLR, compared to 𝛅UTE, was advantageous for greater signal to noise ratio for the cortical bone, as well as higher resolution that depicted trabecular structures. Impact: This study advances MR imaging of the bone, for specific use cases such as morphologic evaluation. The FE technique in particular is immediately translatable using existing sequences to help evaluate knee bone in the clinical settings. |
| 5040.
| Efficient and Complete Fat Suppression in 2-point Dixon MRI for Improved Qualitative and Quantitative Assessment of Lumbar Plexus Sheng Qing Lin1, Durga Udayakumar1,2, Avneesh Chhabra1, and Ananth J Madhuranthakam1,2 1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States Keywords: Other Musculoskeletal, Fat, Fat Suppression, Dixon Motivation: The use of 2-point Dixon is prevalent for fat/water separation in MRI, but suffers from incomplete fat suppression, leading to residual fat signal in the water image. We have previously developed a “Darkfat” post-processing technique that can reduce this residual signal. Goal(s): This retrospective study aims to evaluate Darkfat processing in clinical lumbar plexus images. Approach: Retrospective 2-point T2-weighted lumbar images from 30 patients were processed using Darkfat and evaluated through qualitative and quantitative assessment. Results: Water-only images from Darkfat processing had significantly better fat suppression (P<0.0001), and subjectively better image quality (P<0.005) compared to original water images from 2-point T2-weighted Dixon acquisition. Impact: Darkfat image processing significantly improves fat suppression in clinical 2-point T2-weighted lumbar images enabling enhanced anatomical visualization. This could potentially improve pathological visualization. |
| 5041.
| Evaluation of the change in magnetic susceptibility values of knee joint cartilage in patients with osteoarthritis using UTE-QSM Jing Li1, Shaoxin Xiang2, Xianqi Wang3, Xiaohong Tian1, Bing Ji1, Shanshan Hu1, Ming Zhang4, Yu Xin Yang2, Hongjiang Wei4,5, and Wei Chen3 1Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China, Chongqing, China, 2MR Collaboration, United Imaging Research Institute of Intelligent Imaging, Beijing, China, Beijing, China, 37T Magnetic Resonance Imaging Translational Medical Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China, Chongqing, China, 4School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, Shanghai, China, 5The National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), Shanghai Jiao Tong University, Shanghai, China., Shanghai, China Keywords: Cartilage, Joints, UTE-QSM Motivation: Quantitative susceptibility mapping (QSM) may be a useful tool for studying the characteristics of collagen fibers in knee cartilage.The susceptibility quantification using GRE with fat saturation and relatively long TE may be further improved using UTE-QSM. Goal(s): To measure the change in susceptibility values of knee cartilage in patients with different grades of OA using UTE-QSM. Approach: A total of 13 knees from 10 patients who underwent both X-ray and MRI-UTE were enrolled. Results: Our results show that in the posterior regions of the medial femoral condyle and lateral femoral condyle, the magnetic susceptibility value significantly decreases with the increase of OA grade. Impact: UTE-QSM can promote osteoarthrologists and
radiologists to better understand knee OA from different dimensions, and can
provide more imaging evidence for monitoring the progress of OA, formulating
treatment plans, and evaluating treatment effects. |
| 5042.
| A systematic automated post-processing approach for quantitative analysis of 3D T1ρ knee MRI Junru Zhong1, Yongcheng Yao1,2, Fan Xiao3, Michael Tim-Yun Ong4, Kevin Ki-Wai Ho4, Queenie Chan5, James F Griffith1, and Weitian Chen1 1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Sha Tin, NT, Hong Kong, 2School of Informatics, University of Edinburgh, Edinburgh, United Kingdom, 3Department of Radiology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, 4Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Sha Tin, NT, Hong Kong, 5Philips Healthcare, Sha Tin, NT, Hong Kong Keywords: Cartilage, Software Tools Motivation: To address the global healthcare challenge of knee osteoarthritis. Goal(s): Develop and validate an automated post-processing method for quantitative 3D T1ρ knee imaging analysis. The proposed post-processing pipeline accelerates the process while preserving a user-friendly and clinical-related output. Approach: We proposed a post-processing pipeline that combines parcellation, ROIs selection, T1rho fitting, and regionally averaged outputs. We evaluated our approach on 30 OA patients and 10 healthy controls. Results: The proposed post-processing approach achieved satisfactory performance on automatic ROI selection compared to the manually labelled ROIs and provided quantitative T1ρ analysis with clinical promise. Impact: Our
proposed pipeline enables automated post-processing for T1ρ imaging with deep
learning, pushing this promising technique to the clinics to provide sensitive
and quantitative knee OA diagnostics. |
| 5043.
| Clinical value of a 10-minute deep-learning reconstruction fast spinecho knee magnetic resonance imaging protocol including T2 mapping Xiaxia Wu1, Weiyin Vivian Liu2, and Yunfei Zha1 1Renmin Hospital of Wuhan University, Wu Han, China, 2GE Healthcare China, Beijing, Beijing, China Keywords: Cartilage, Quantitative Imaging Motivation: T2 mapping is difficult to be implemented in clinics for long scan time. Goal(s): To propose a 10-minute fast spin echo knee MRI protocol including quantitative T2 map and morphologic images in identifying cartilage injury or grading cartilage degeneration. Approach: To subjectively and objectively assess the clinical value of knee imaging with different acceleration factor of 2 and 3 as well as using conventional and deep learning reconstruction algorithms (CR, DLR). Results: Both FSEDLR and DL-based quantitative T2 map with either an acceleration factor of 2 or 3 elevated diagnostic accuracy using a senior rater as a final diagnosis. Impact: A knee protocol including deep-learning based FSE structure imaging and quantitative T2 map could be facilitated in clinical application further elevating the diagnostic accuracy and performance. |
| 5044.
| MRI metrics can help explain the loss of functional strength in aging Mary Elizabeth Hall1, Yael Vainberg1, Jessica Asay1, Jennifer Hicks2, Julie Muccini1, Garry Gold1, and Valentina Mazzoli3 1Radiology, Stanford University, Stanford, CA, United States, 2Bioengineering, Stanford University, Stanford, CA, United States, 3Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University, New York, NY, United States Keywords: Muscle, Aging Motivation: There is a need to investigate the relationship between age-related muscle atrophy and functional strength. Goal(s): To explore the relationship between volumes of individual knee extensor muscles relative to total volume of the quadriceps as measured by MRI and sit to stand performance. Approach: Participants performed a sit to stand test while being recorded by a markerless motion capture system and underwent an MRI exam that included a Dixon scan, which was used to calculate muscle volumes in the quadriceps. Results: There were correlations between age and vastus intermedius and vastus lateralis volume. Rectus femoris volume was correlated with sit to stand performance. Impact: We utilized a novel experimental design using smartphone-based markerless motion capture and MRI metrics to study the relationship between functional strength and age-related muscle atrophy. This work could inform design of physical therapy programs for the elderly. |
| 5045.
| Use An Automated Pipeline to Quantify Erector Spinae Muscle Asymmetry and Correlate It with Quality of Life in Adult Degenerative Scoliosis Qi Zhang1, Chenglong Wang1, Chengxiu Zhang1, Haijie Wang2, Yang Song3, Jun Zhao4, and Guang Yang1 1Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, ShangHai, China, 2Institute of Research and Clinical Innovations, Neusoft Medical Systems Co., Ltd., Beijing, China, 3MR Research Collaboration Team, Siemens Healthineers Ltd., ShangHai, China, 4Department of Radiology, The First Affiliated Hospital, Army Medical University, Chongqing, China Keywords: Muscle, Data Analysis Motivation: To explore the influence of erector spinae muscle asymmetry to adult degenerative scoliosis (ADS) on patients' quality of life. Goal(s): To develop a pipeline for automated quantification of the normalized FCSA difference index (CDI) and left-right fat Infiltration asymmetry ratio (LFIAR) from MRI images for assessment of ADS. Approach: We used nnU-Net for precise anatomical segmentation on T2 images. Then, CDI and LFIAR were calculated and correlated to ADS scales. Results: The automated model adeptly delineated paravertebral muscle groups, which were used to calculate CDI and LFIAR. Noteworthy correlations between CDI, LFIAR, and ADS scales were found among male subjects. Impact: This research streamlines clinical workflows, imparts valuable insights into the severity of ADS, and equips clinicians with crucial data for informed clinical decision-making. |
| 5046.
| A multipurpose Adolescent Idiopathic Scoliosis specific short MRI protocol: feasibility study in volunteers. Yulia M Shcherbakova1, Peter P.G. Lafranca2, Wouter M Foppen3, Tijl A van der Velden1,4, Rene M. Castelein2, Keita Ito2,5, Tom P.C. Schlosser2, and Peter R Seevinck1,4 1Department of Radiology, Image Sciences Institute, UMC Utrecht, Utrecht, Netherlands, 2Department of Orthopaedics, UMC Utrecht, Utrecht, Netherlands, 3Department of Radiology, Division Image and oncology, UMC Utrecht, Utrecht, Netherlands, 4MRIguidance B.V., Utrecht, Netherlands, 5Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands Keywords: Skeletal, Skeletal, Scoliosis, MSK, Spine, sCT, synthetic CT Motivation: To date, there is no description of an optimal MRI protocol for detection of early changes in the scoliotic spine. Goal(s): The goal is to assess the feasibility of the multi-purpose short MRI protocol based on the MR data of adult volunteers. Approach: Based on the checklist of relevant landmarks, assessment of the volunteer MR data and identification of the landmarks was performed by 3 readers. Results: We have demonstrated that the proposed MRI protocol, covering almost the entire spine in 14 min, is efficient for detection of relevant landmarks for: scoliosis assessment, screening for neural axis abnormalities, and surgical planning and navigation. Impact: A
short MRI protocol is developed for accurate assessment of spinal deformity in
AIS patients, facilitating the treatment management, monitoring and surgical
planning, and simplifying the clinical workflow. |
| 5047.
| DTI-MRI as a non-invasive assessment of extracellular matrix remodeling in lumbar paravertebral muscles of rats with sarcopenia Xinchen Huang1 and Bo He1 1The First Affiliated Hospital of Kunming Medical University, kunming, China Keywords: Muscle, Aging Motivation: The evaluation of extracellular matrix levels in skeletal muscle often requires tissue biopsy, which is difficult for patients to accept in clinical practice Goal(s): We evaluated the extracellular matrix level of skeletal muscle using non-invasive magnetic resonance imaging technology and conducted pathological verification using skeletal muscle samples from rats with sarcopenia Approach: We constructed a classic sarcopenic rat model , scanned the lumbar paravertebral muscles with a 3.0T MRI-based DTI sequence, and validated through histological experiments Results: FA and CSA of sarcopenic rats were significantly reduced compared to the normal control group, and there was a strong correlation between them and pathological related parameters Impact: Our study provides
a non-invasive tool for evaluating the extracellular matrix levels of skeletal
muscles in sarcopenia |
| 5048.
| Muscle Kinetics on Diffusion-weighted Imaging during Plantar Flexion for Assessing Sex Differences in Age-related Muscle Quality Xinyue Zhang1, Pei Xiang1, Kan Deng2, and Zhaohui Zhang1 1First affiliated hospital of SYSU, Guangzhou, China, 2Philips Healthcare, Guangzhou, China Keywords: Muscle, Aging Motivation: The exercise-tailored diffusion-weighted imaging (DWI) protocol has never been implemented to assess sex differences in age-related muscle quality in the healthy population. Goal(s): To investigate the feasibility of muscle kinetics on DWI during exercise for assessing sex differences in age-related muscle quality. Approach: This study recruited 87 healthy participants with 174 legs imaged and assessed muscle kinetics on DWI during exercise for assessing sex differences in age-related muscle quality. Results: Males and females showed different age-related pattern with muscle kinetics on DWI during plantar flexion. Impact: An exercise-tailored MR protocol can be implemented for assessing the muscle quality. |
| 5049.
| 3D high-resolution isotropic multi-contrast knee MRI using 3D mDixon TSE with deep learning constrained Compressed SENSE Yasuyuki Morita1, Michinobu Nagao1, Masami Yoneyama2, Mana Kato1, Takumi Ogawa1, Kazuo Kodaira1, Yutaka Hamatani1, Isao Shiina1, Yasuhiro Goto1, and Shuji Sakai1 1Tokyo Women's Medical University Hospital, Tokyo, Japan, 2Philips Japan, Tokyo, Japan Keywords: Cartilage, Artifacts Motivation: Knee joint MRI requires m sequences involving multiple planes and with- and without fat suppression, which is time-consuming. Goal(s): Provides detailed cartilage and ligament information in a short period of time and allows multiplanar reconstruction in any plane of any thickness from a single high-resolution isotropic imaging. Approach: CS-AI 3D mDixon TSE images were compared with conventional SENSE and CS images. Results: It indicated that 3D mDixon CS-AI can provide more accurate image information of cartilage and ligaments with high reproducibility and robustness. Impact: This technique may be helpful to further assess knee pathology. |
| 5050.
| 31P-MRS measured phosphocreatine recovery kinetics in human muscles during health and disease: a meta-analysis Maninder Singh1, Aditya Jhajharia2, Rajat Pruthi3, and Owen Carmichael4 1Biomedical Imaging, Pennington Biomedical Research Center, Baton Rouge, LA, United States, 2University of Maryland Baltimore, Baltimore, MD, United States, 3Louisiana State University, Baton Rouge, LA, United States, 4Pennington Biomedical Research Center, Baton Rouge, LA, United States Keywords: Muscle, Spectroscopy, Skeletal muscle metabolism Motivation: 31P-MRS methodology is notoriously laboratory-specific, leading to uncertainty about the normal range of PCr recovery kinetics among healthy individuals, as well correlations with disease and demographic factors. Goal(s): Our aim was to characterize the normal range of PCr recovery measurements from 31P-MRS in human skeletal muscles, as well as correlations with age and end-of-exercise pH. Approach: Included studies focused on exercise-induced skeletal muscle PCr recovery kinetics in healthy or diseased individuals, using 31P-MRS. Results: PCr recovery time is consistent across three skeletal muscle groups in healthy individuals from diverse MRI centers. Greater age and more acidic pH increase PCr recovery time. Impact: These results will set the indexes for PCr recovery kinetic measures across different human skeletal muscles. |
| 5051.
| The application of 3D-ZTE technique in ex vivo ankle cortical bone MRI of adolescent pigs: A comparison with CT examination Wanjing Bai1, Xian Xiong1, Yaqi Li1, Lingjun Jiang1, Xiyang Song1, Xiaoxuan Li1, and Huilou Liang2 1West China Second University Hospital, Sichuan University, Chengdu, China, 2GE HealthCare MR Research, Beijing, China Keywords: Bone, MSK, ZTE Motivation: Exploring non-ionizing radiation alternatives to CT examination for diagnosing bone diseases in children is clinically desirable. Goal(s): To compare the visualization of the bone cortex around ankle joints of adolescent pig between 3D-ZTE MRI and CT techniques. Approach: A total of 12 specimens were subjected to both 3D-ZTE MRI and CT examination. The thicknesses of bone cortex were measured and compared between MRI and CT images. Results: There was no significant difference in the thicknesses of bone cortex in the inner and outer sides of tibia, fibula, and talus between 3D-ZTE and CT. Impact: 3D-ZTE technique can obtain CT-like
images that accurately measure the thickness of bone cortex without ionizing
radiation. This technique holds the potential for clinical applications in
children with bone diseases, providing a safe alternative to traditional CT
imaging. |