|
| 4830.
 | Comparison of Stiffness Measurement Variability in MRE Phantoms using Different Passive Drivers Raphael do Vale Souza1, Jeff Kammerman2, David Rutkowski2, Jitka Starekova1, Phillip J. Rossman3, Kay Pepin4, Diego Hernando5, Jean H. Brittain2, and Scott B. Reeder1
1Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Calimetrix, Madison, WI, United States, 3Mayo Clinic, Rochester, MN, United States, 4Resoundant, Rochester, MN, United States, 5University of Wisconsin-Madison, Madison, WI, United States Keywords: Phantoms, Phantoms, Elastography, Stiffness Motivation: Quantitative quality assurance (QA) methods for magnetic resonance elastography (MRE) are needed for clinical care but are currently unavailable.
Goal(s): Evaluate stiffness measurement variability from two phantoms of different stiffness using four types of passive drivers: two commercial drivers, a custom stand-style driver, and a novel driver integrated into the phantom housing.
Approach: Stiffness measurements were quantified in ten acquisitions in two phantoms of differing stiffness by four passive drivers. Measurement variability was compared by standard deviations and Whisker-and-Box plots.
Results: The integrated driver achieved the best performance with the highest repeatability, ie: lowest variability, compared to the other drivers.
Impact: An MRE phantom equipped with an integrated passive driver could improve repeatability in MRE quality assurance, potentially enhancing the reliability of QA processes in both clinical trials and patient care.
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| 4831.
 | An In-Depth Analysis of Liver Fat Quantification Using 5T MRI: A Comparative Study with 1.5T MRI MRS-PDFF Jianxian Liu1, Zhensong Wang1, Dan Yu2, Yanxing Yang3, Chao Zou4, Chuanli Cheng4, Xiangsen Jiang1, Peng Chen1, and Jie Gan1
1Shandong Provincial Third Hospital, Jinan, China, 2United Imaging Research Institute of Intelligent Imaging, Beijing, China, 3Shanghai United Imaging Healthcare Co., Shanghai, China, 4Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China Keywords: High-Field MRI, High-Field MRI, Fat & Fat/Water Separation Motivation: Nonalcoholic fatty liver disease (NAFLD) is an escalating health issue, necessitating precise noninvasive measurement of hepatic steatosis. Goal(s): To evaluate the feasibility and accuracy of 5T magnetic resonance spectroscopy (MRS) for in vivo liver fat quantification. Approach: The study utilized phantoms with controlled fat content and 20 volunteers, comparing proton density fat fraction (PDFF) values measured by 5T MRS against those from 1.5T MRS. Results: The 5T MRS demonstrated strong consistency with 1.5T measurements, validating its potential in clinical diagnostics despite technical challenges associated with ultra-high-field MRI applications. Impact: The study's validation of 5T MRS for liver fat
quantification could enhance diagnostic precision for liver conditions,
influencing clinical practices and guiding future technological advancements in
MRI diagnostics. |
| 4832.
 | Computational Fluid Dynamics Of Bladder Voiding Using 3D Dynamic MRI Labib Shahid1, Juan Pablo Gonzalez-Pereira1, Cody Johnson1, Wade Bushman1, and Alejandro Roldan-Alzate1
1University of Wisconsin-Madison, Madison, WI, United States Keywords: In Silico, In Silico, MRI-based CFD, Urodynamics Motivation: Catheter-based urodynamic studies to assess bladder dysfunction are invasive and provide inadequate biomechanical information. MRI-based computational fluid dynamics (CFD) has demonstrated potential to uncover these features not evident from catheterization. Goal(s): Develop and implement a computational methodology to non-invasively assess urodynamics. Approach: Acquire 3D dynamic MRI of bladder voiding. Use the images to execute subject-specific CFD simulations of the bladder and urethra. Calculate existing urological nomograms and energy expended to quantify bladder function using the MRI and CFD results. Results: The healthy subject showed unobstructed bladder outlet and normal contractility. We calculated the energy expended to void bladder for the first time. Impact: A method using MRI-based computational fluid dynamics was developed to simulate bladder voiding. Results show successful quantification of urine flow dynamics. This method shows potential to overcome limitations of current invasive catheter-based urodynamic studies. |
| 4833.
 | Simultaneous R2* Relaxometry and Dixon Imaging of Liver and Kidney at 3T Using Bilateral Orthogonality Generative Acquisitions Method Çelik Boğa1 and Anke Henning1
1UT Southwestern Medical Center, Dallas, TX, United States Keywords: Whole Body, Body, liver, kidney, parallel transmission, Dixon imaging Motivation: Improving the quality of body R2*( T2* ) images by removing transmit field inhomogeneity while utilizing Dixon imaging in body at 3T. Goal(s): Implementation of Bilateral Orthogonality Generative Acquisitions method for simultaneously obtaining homogeneous R2*( T2* ) and Dixon imaging fro kidney and liver at 3T. Approach: Bilateral Orthogonality Generative Acquisitions method was improved to include phase effect that enables the use of Dixon Imaging. Multi-echo acquisitions are utilized for R2* estimation. Results: Implementation of Bilateral Orthogonality Generative Acquisitions method enables the simulataneous R2*( T2* ) and Dixon imaging and eliminates the central brightnening effect. Impact: Simultaneous homogeneous R2*( T2* ) and Dixon imaging is implemented within same scan time required for Dixon imaging while removing the central brightening effect in body imaging at 3T. |
| 4834.
 | Creating Digital Twins of Solid Tumors: Insights from Dynamic Contrast-Enhanced MRI Hooman Salavati1,2, Wim Ceelen1, Charlotte Debbaut2, and Pim Pullens3
1Department of Human Structure and Repair, Ghent University, Ghent, Belgium, 2IBiTech – BioMMeda, Ghent University, Ghent, Belgium, 3Department of Radiology, Ghent University Hospital, Ghent, Belgium Keywords: In Silico, Quantitative Imaging, Digital twin Motivation: Prediction of cancer therapy outcomes is a paramount objective in oncology, closely tied to the integration of novel biomarkers into clinical practice. Goal(s): The goal of creating digital twins of solid tumors is to equip oncologists with a comprehensive replica of the tumor, allowing them to make well-informed decisions. Approach: In the development of digital twins for solid tumors, we introduce a multidisciplinary approach that essentially combines quantitative MRI and computational modeling. Results: The image-based model yields a comprehensive representation of tumor perfusion, providing a map of elevated interstitial fluid pressure, which holds significant potential as a biomarker in oncology. Impact: Cancer therapy's success is not guaranteed, with potential serious
side effects. Our aim is to offer a robust digital tumor replica for evaluating
numerous treatment options, identifying the optimal plan while minimizing
adverse effects. |
| 4835.
 | Elastic modulus of acetabular labrum correlates with UTE apparent spin-spin (T2*) and spin-lattice (T1) magnetic resonance relaxation times Dina Moazamian1, Takehito Hananouchi2,3, Hamidreza Shaterian Mohammadi1, Arya Suprana1, Alireza Tayarani4, Erik W Dorthe3, Darryl W D’Lima3, Yajun Ma5, and Saeed Jerban5
1Radiology, University of California San Diego, San Diego, CA, United States, 2Academia-Government-Industry Collaboration, Office of Research and Academia-Government-Community Collaboration Hiroshima University, Hiroshima, Japan, 3Orthopedic, Shiley Center for Orthopedic Research and Education at Scripps Clinic, San Diego, CA, United States, 4Pathology, University of California San Diego, San Diego, CA, United States, 5Radiology, Radiology, University of California San Diego, San Diego, CA, United States, San Diego, CA, United States Keywords: High-Field MRI, Cartilage, Acetabular Labrum, UTE Motivation: The acetabulum labrum plays a critical role in the hip function. Medical imaging techniques for detecting labral degeneration may help improve our knowledge of its role in hip osteoarthritis (OA). Goal(s): This study aimed to explore the correlation between the mechanical properties of the acetabulum labrum and MRI properties. Approach: The correlations of UTE-T2* and -T1 sequences with the tensile elastic modulus of human acetabular labrum specimens have been investigated. Results: There was a significant correlation between quantitative UTE-T2*, and UTE-T1 techniques and the mechanical properties of the labrum. Impact: UTE-T2*
and -T1 sequences showed the potential to evaluate acetabulum labrum mechanical
assessment, which is needed to improve labrum degeneration detection and
monitoring, a primary unmet need in areas where hip osteoarthritis is common
and conventional MRI is being implemented. |
| 4836.
 | Multi-parametric Quantitative Magnetic Resonance Imaging Phantom Hannah E Alderson1,2, Scott D Swanson3, William Reichert1,2, Daniel F Gochberg2,4, and Mark D Does1,2,4
1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 3Radiology, University of Michigan, Ann Arbor, MI, United States, 4Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States Keywords: Phantoms, Phantoms, multiparametric Motivation: Currently there is no qMRI phantom that simultaneously reproduces the many contrasts that are present in white matter. Goal(s): The goal of this work is to characterize a single multiparametric qMRI phantom that exhibits diffusion, magnetization transfer and MET2 properties. Approach: Aqueous MTF and PVP were combined in varying concentrations and evaluated with both NMR and MRI. Results: A homogenous, multiparametric qMRI phantom was created with an array of tissue relevant parameters: T2L ranging from 71.9-183 ms, T2s ranging from 13.6-17.7 ms, fs ranging from 0.118-0.177, T1free ranging from 1479-1919 ms and fm ranging from 0.053-0.109. Impact: A multiparametric phantom allows for improved quality assurance analysis, as well as sequence development by allowing for multiple contrasts to be evaluated simultaneously. Ultimately providing a sample that is controlled, yet more akin to what occurs in biological samples. |
| 4837.
 | Does the stability assessment of an MRI scanner depend on the phantom used? Negar Amirafshari1, Anestis Passalis2, Frank Bolton3, Tom Hampshire3, Antonio Ricciardi2, Aaron Oliver-Taylor3, Xavier Golay1,3, and Marios C Yiannakas2
1Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom, 2NMR Research Unit, UCL Queen Square Institute of Neurology, London, United Kingdom, 3Gold Standard Phantoms, Sheffield, United Kingdom Keywords: Phantoms, Phantoms, Reproducibility, Test-Retest Motivation: The demonstration of the independence of fBIRN QA metrics on the phantom used would enable an easy cross-scanner comparison of scanner stability, thus improving such QA for clinical use (e.g., presurgical mapping). Goal(s): The goal of this study was to assess the variance measured using such metrics across phantoms. Approach: Nine identical phantoms were scanned on a single 3T scanner. Relaxometry and fBIRN scanning was performed on all phantoms and compared to those measured on a single phantom scanned 15 times. Results: No significant difference was found between phantoms on either their relaxivities, or their QA fBIRN parameters. Impact: The independence of fBIRN QA metrics on the phantom used found
in this work enables the use of generalised QA across MRI
scanners to assess their capacity at providing high quality fMRI for presurgical mapping, thereby ensuring optimal patient
outcomes. |
| 4838.
 | Enabling reproducible measurements of Fat Fraction and Iron content using an SI traceable reference phantom Matt Cashmore1, Cailean Clarkson2, Ben P Tatman1, Katie Obee1, Jack Clarke1, Nadia Smith1, Frederic Brochu1, Elizabeth Cooke1, Asha Ford-Scille1, Jessica Goldring1, Robert Hanson1, Asante Ntata1, Susan Rhodes1, Simone Busoni3, Aaron McCann4, Cormac McGrath4, Riccardo Ferrero5, Alessandra Manzin5, Adriano Troia5, Sarah Hill2, Sumiksha Rai6, Stanislav Strepokytov2, Christian Ward-Deitrich6, Alen Bosnjakovic7, Paul Tofts8, Tugba Dispinar9, Ilker Un10, Amy McDowell11, Stephen Wastling11, John Thornton11, Nick Zafeiropoulos11, Sian Curtis12, Richard Scott12, Holly Elbert12, Jonathon Delve12, Cameron Ingham12, Amar Deumić13, Lejla Gurbeta Pokvić13, Merima Smajlhodžić-Deljo13, and Matt Hall1
1National Physical Laboratory, Teddington, United Kingdom, 2National Measurement Laboratory, LGC, Teddington, United Kingdom, 3AOU Careggi, Firenze, Italy, 4Belfast Health and Social Care Trust, Belfast, United Kingdom, 5Istituto Nazionale di Ricerca Metrologica, Torino, Italy, 6National Measurement Laboratory, Teddington, United Kingdom, 7Institute of Metrology of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina, 8Brighton and Sussex Medical School, Brighton, United Kingdom, 9TÜBİTAK, Ankara, Turkey, 10TÜBİTAK, Ankara, United Kingdom, 11University College London, London, United Kingdom, 12University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom, 13VERLAB, Sarajevo, Bosnia and Herzegovina Keywords: Phantoms, Phantoms, Metrology, Traceability Motivation: Quantitative MRI is a powerful tool for measuring a variety of biological parameters, with two common biomarkers of interest being fat fraction and Iron content. Goal(s): We present here a test object for these parameters which is supported by fundamental metrology and traceable to the SI system. Approach: Initial scan data taken at 1.5T is compared with traceable measurements of phantom properties Results: We see significant variation seen in clinical results of the same phantom even with standardised protocols, outside the range of phantom validation. Impact: We demonstrate a new gold standard and verified phantom for fat and iron measurement, traceable to primary standards. We present results using standardised MRI protocols which is vital for understanding and improving standards and best practice guidelines in the future. |
| 4839.
 | A Generalized Real-time Frequency Adjustment Approach for MRSI Marcus J. Couch1, Lumeng Cui1, and Sinyeob Ahn2
1Siemens Healthcare Limited, Oakville, ON, Canada, 2Siemens Medical Solutions, Malvern, PA, United States Keywords: System Imperfections, Spectroscopy Motivation: Spectroscopy is sensitive to frequency drift. After running sequences that have a high gradient duty-cycle, frequency continues to drift due to gradient cooling. Goal(s): To propose a generalized prospective real-time frequency correction that can be applied to imaging and spectroscopic sequences, where TR-variant and -invariant events are separable in time. Approach: Real-time frequency adjustment was implemented for CSI, using a navigator placed where the spin phase is consistent across TR cycles prior to the CSI readout. Results: Phantom measurements with the generalized navigator provide accurate estimates of the frequency drift, thereby minimizing spectral distortion and providing an improved baseline in the final spectra. Impact: Prospective real-time frequency adjustment using a generalized
navigator approach, where the spin phase is consistent across TR cycles, can be
applied to spectroscopic imaging to correct for frequency drift caused by
gradient heating and cooling. |
| 4840.
 | Measuring CSF net velocity using DENSE at 7T with improved correction for involuntary motion and eddy currents. Elisabeth van der Voort1, Merlijn van der Plas1, and Jacobus Zwanenburg1
1Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands Keywords: Neurofluids, Neurofluids, CSF, Velocity & Flow, Clearance, Brain, Neuro Motivation: Clearance is important for healthy brain functioning. The ability to measure CSF net velocity would be valuable to gain insight into the underlying mechanisms and pathways of clearance. Goal(s): To measure CSF net velocities in FH and RL direction whilst accounting for periodic motions, involuntary head motion and eddy currents. Approach: A multi-slice single shot DENSE acquisition is used to measure CSF displacements over time. Results: The measured net velocity does not fit the classical view on CSF excretion and absorption locations. Further validation is needed using a moving flow phantom. Impact: The measured
net velocities are about 10 percent of what would be expected. If confirmed in
a larger cohort, the results challenge the classical view of main CSF excretion
at the choroid plexus and absorption at the sagittal sinus. |
| 4841.
 | Acoustic Noise Optimization of Trapezoid Oscillating Diffusion Encoding Gradient Xingzhou Chen1, Liyi Kang1,2, Qinfeng Zhu1, Yi-Cheng Hsu3, Xu Yan3, and Dan Wu1
1Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2Center for Intelligent Biomedical Instrumentation, Zhejiang University Binjiang Research Institute, Hangzhou, China, 3MR Collaboration, Siemens Healthcare China, Shanghai, China Keywords: Gradients, Safety, Gradients Optimization, Acoustic Noise, OGSE Motivation: Oscillating gradient spin-echo (OGSE) diffusion MRI sequence involves diffusion preparation and EPI readout, both having rapidly switching trapezoid gradient. Consequently, OGSE sequence generates strong acoustic noise that may introduce comfortless patient experience. Goal(s): Our study aims to develop an optimization framework to suppress the acoustic noise by softening the trapezoid gradient. Approach: We measured the acoustic noise frequency response function of scanner. Based on linear model of MRI acoustic noise generation, we designed a convex optimization framework to reduce the predicted A-weighting sound pressure level(SPL) Results: Optimized gradient achieved 14.09dBA SPL reduction according to our FRF based prediction. Impact: We
developed an effective optimization method to reduce the acoustic noise of
oscillating trapezoid gradient waveform, and potentially facilitate the clinical
applications of OGSE. This optimization framework also has potential to reduce acoustic
noise of EPI readout waveform |
| 4842.
 | Initial experience of proton short echo MR spectroscopy of human brain at 5T Hongxia Lei1,2, Linfei Wen1, Bin Deng3, Aiguo Xue1, and Chaohong Wang1
1United-Imaging Healthcare, Shanghai, China, 2Wuhan United-Imaging Life Science Instrument Ltd Co., Wuhan, China, 3United-Imaging Healthcare, Shenzhen, China Keywords: High-Field MRI, Metabolism, spectroscopy Motivation: Proton short echo (TE≤10ms) MR spectroscopy of human brain at high magnetic fields (≥3T) provides abundant metabolic information beyond MR images, but remains challenging for routine clinical usages beyond 3T. Goal(s): To evaluate feasibility and assess quality of proton ultrashort echo (i.e.10ms) MR spectroscopy of human brain on a clinical, whole-body 5T MRI system. Approach: Stimulated echo acquisition mode (STEAM) spectra with TE=10ms were obtained in human brain at 3T and 5T. Results: The feasibility of short echo MR spectroscopy of human brain at 5T was first demonstrated. The spectral quality is substantially improved when compared to 3T. Impact: The quality of short echo MR spectra at 5T could be reached without exceeding the SAR and thus may offer additional metabolite information for large amount of clinical diagnostic applications. |