ISSN# 1545-4428 | Published date: 19 April, 2024
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At-A-Glance Session Detail
   
Gender Imaging: Prostate & Female Pelvis
Weekend Course
ORGANIZERS: Nandita DeSouza, Durgesh Dwivedi, Mami Iima, Takeshi Yokoo
Saturday, 04 May 2024
Room 331-332
13:00 -  16:50
Moderators: Masoom Haider & Masako Kataoka
Skill Level: Intermediate to Advanced
Session Number: WE-16
CME Credit

Session Number: WE-16

Overview
This course covers male and female reproductive organs including aspects of fetal imaging. It will focus mainly on cancer imaging (from staging to recurrent disease) of the prostate, uterine body, cervix, and ovaries. In each case, newer techniques such as radiomics and the use of AI for enhancing diagnostic capability will be discussed.

Target Audience
Clinicians with an interest in oncological imaging of the male and female reproductive tracts. Scientists with an interest in radiomic techniques and in exploiting AI in the clinic.

Educational Objectives
As a result of attending this course, participants should be able to:
- Describe the classification systems and staging of prostate, endometrial, cervix and ovarian cancer;
- Describe what radiomics adds to diagnosis in reproductive organ malignancies; and
- Identify the advantages of AI in pelvic imaging, particularly its use in monitoring fetal growth.

13:00Uterine Cancer: T2W or Texture?
Yuki Himoto

Keywords: Body: Urogenital

Motivation: Conventional MRI is crucial for uterine cancer in clinical settings. Radiomics, utilizing quantitative imaging features, has rapidly evolved in research. A brief review provides insights for addressing current clinical challenges and guiding future developments.

Goal(s): The goals are to grasp the roles of conventional MRI, achievements in radiomic studies for uterine cancer (particularly endometrial cancer), and the limitations and improvements in imaging quality.

Approach: Reviewing the latest research on MRI and radiomics in uterine cancer, with a primary focus on endometrial cancer.

Results: Despite limitations, radiomics continues to advance. Improvements in conventional MRI quality for gynecologic imaging are clinically significant and enhance radiomics.

Impact: Grasping current improvements in MRI quality and radiomics, along with identifying challenges, offers insights for addressing clinically relevant issues in uterine cancer.

13:25 Cervical Cancer: T2W or Texture?
Luca Russo

Keywords: Body: Urogenital

  • The role of conventional MRI in cervical cancer imaging is well-established, with guidelines universally recognizing it as the modality of choice for staging, assessing treatment response, and selecting candidates for fertility-sparing treatments.
  • The cutting-edge applications of texture analysis will be explored, highlighting its potential to significantly expand the capabilities of MRI.
  • Particular attention should be paid to to currently unmet clinical needs, showcasing relevance and potential impact of texture analysis on patient management.
  • This analysis aims to bridge the gap between existing MRI techniques and the evolving demands of management, pointing towards innovative tailored approaches.
13:50 Ovarian Cancer: T2W or Texture?
Aki Kido

Keywords: Body: Pelvis

Motivation:T2WI, i.e. traditional morphological image diagnosis is good at ‘present’ histopathological diagnosis. On the other hand, recent texture, i.e. radiomics analysis can provide invisible information and make ‘future’ diagnosis including prognosis and treatment response.
Goal(s): Clinical radiologists need to know the pros and cons of both morphological diagnosis and texture analysis and know how to get the necessary information when we need it.
Approach: -
Results: -
Impact: -
14:15 Advanced Morphofunctional Sequences & AI in the Evaluation of Fetal Growth Anomalies
Lucia Manganaro

Keywords: Image acquisition: Image processing, Image acquisition: Sequences, Image acquisition: Motion Correction

Intrauterine growth restriction (IUGR) is the fetal failure to reach its biological growth potential and placental dysfunction is the main cause IUGR is distinguished into Small for Gestational Age (SGA) and Fetal Growth Restriction (FGR). Ultrasound represents the technique of choice for the diagnosis and the  Functional Doppler parameters improve this distinction as established by the Expert Consensus Statement. The differentiation is important: many SGAs are constitutionally small but healthy without risk of poor outcomes unlike FGRs. 
Magnetic Resonance Imaging (MRI) and Diffusion weighted imaging (DWI) can evaluate placenta and fetal growth supporting the diagnosis of developmental pathologies
14:40 Break & Meet the Teachers
15:10The Problem with PI-RADS
Yan Mee Law

Keywords: Body: Urogenital, Cross-organ: Cancer, Image acquisition: Multiparametric

PI-RADS v2.1 is widely adopted by the international radiology and urology communities in risk assessment of clinically significant prostate cancer (csPCa) at multi-parametric MRI (mpMRI) in treatment naïve men.  This consensus document, aimed at establishing uniformity in acquisition and interpretation of mpMRI, has been prone to performance variations.  A non-negligible number of csPCa are missed at mpMRI as these lesions resemble benign lesions or possess mpMRI features that do not fit a defined PIRADS category. We discuss the limitations and controversies of PIRADS and tips and tricks that may be useful to improve the conspicuity of “MRI occult” csPCa.
15:35 Radiomic & Radiogenomic Signatures in Prostate Cancer
Daniel Moses

Keywords: Body: Pelvis, Body: Urogenital, Education Committee: Clinical MRI

Radiomics and genomics have potential to add value in the diagnosis and risk stratification of cancer. Radiomics analyses quantitative imaging biomarkers of tumours in medical images, such as morphological, histogram and texture features, whereas genomics investigates genetic elements of cancer tissue. Combining these into radiogenomics enables the generation of combinations of features, known as signatures, that can predict cancer phenotypes which effect the biological properties and therefore the behaviour of tumours. This presentation examines MRI radiomics and radiogenomics and their use in aiding the screening, detection, classification, treatment, and prognosis of prostate cancer.
16:00 Two “B” or Not Two “B”: Probing Prostate Tissue Composition
Aritrick Chatterjee

Keywords: Body: Pelvis, Contrast mechanisms: Microstructure, Image acquisition: Quantification

Diffusion MRI is a key component of prostate MRI. A minimum of 2 b-values are needed to derive ADC map. PIRADS guidelines recommend a minimum of 3 b-values: low (0-100 sec/mm2), intermediate (800-1000 sec/m2) and high b-value (≥1400 sec/m2, either acquired or calculated). The talk will highlight how the choice of b-values can significantly affect ADC estimates.
Additionally, we will look at recent advancements in quantitative MRI techniques that probe prostate tissue microstructure. We will look at imaging parameters used and results from these techniques: VERDICT, Restriction spectrum imaging, Hybrid Multi-dimensional MRI, time-dependent diffusion imaging, diffusion-relaxation correlation spectrum imaging, etc.
16:25Exploiting AI in Prostate Cancer Assessment
Amit Mehndiratta

Keywords: Body: Pelvis, Cross-organ: Cancer, Image acquisition: Machine learning

Prostate cancer is sixth leading cause of cancer related death and is one of the most prevalent malignancies in men. Artificial intelligence (AI) methods are potentially useful in prostate cancer management for detection and characterization of prostate lesion. AI solutions are assisting in streamlining patient workflow and optimizing treatment plans for individual patient leading to precision medicine-based approach. Machine learning methods are being used for segmentation of prostate gland and its anatomical structures, image registration, detection of lesions, lesion characterization, automated PI-RADS scoring, and risk stratification, which ultimately leads to enhanced diagnosis, treatment planning, and patient outcomes in prostate-related conditions.