Physical Chemistry Approaches for Contrast Mechanisms I
Sunrise Course
ORGANIZERS: Laura Bell, Shaihan Malik, Marco Palombo, Cristian Tejos
Monday, 12 May 2025
312
07:00 -
08:00
Moderators: Evren Ozarslan
Skill Level: Intermediate to Advanced
Session Number: S-M-07
No CME/CE Credit
Session Number: S-M-07
Overview
The rich history of MRI is marked by techniques evolving from physical chemistry, encompassing, for example, spectroscopy, diffusion, exchange, and quantum filters. This session delves into the contemporary landscape of NMR physical chemistry, exploring untapped methods for integration into MRI scanners. Addressing the shift from in vitro to in vivo applications, practical considerations will be explored. Furthermore, variations in hardware performance will be considered, shedding light on factors influencing the translation of innovative methods into successful MRI applications.
Target Audience
Scientists interested in pushing the boundaries of MR contrasts, aiming toward translating novel techniques from other fields (e.g. chemical-physics) to tissue microstructure imaging.
Educational Objectives
As a result of attending this course, participants should be able to:
• List advanced NMR methods and their Integration into medical applications of MRI;
• Describe how transitioning from in vitro to in vivo applications in NMR and MRI happens; and
• Evaluate hardware performance and its impact on NMR-MRI method translation.
| 07:00 |  | Massive Multi-Dimensional Encodings (Relaxation & Diffusion) Paddy Slator Keywords: Contrast mechanisms: Diffusion, Contrast mechanisms: Microstructure, Contrast mechanisms: Relaxometry This talk introduces the fundamentals of combined diffusion-relaxation MRI for microstructure imaging. Attendees will learn why it is useful, how it is acquired, and how it is analysed. This emerging paradigm simultaneously measures diffusion and relaxation properties, improving sensitivity to tissue microstructure. The talk covers key principles, data acquisition, preprocessing, and analysis, and highlights recent applications in the brain, prostate, and placenta. By the end, attendees will have an overview of how combined diffusion-relaxation MRI is used, why it is important, and how it is being applied to various tissues to enhance microstructural imaging and improve quantitative MRI assessments. |
| 07:30 | | Encoding Filters (Relaxation, Flow & Diffusion) TBD |