Yuexi Huang¹, Ying Meng^2,3, Christopher B. Pople³, Allison Bethune³, Ryan M. Jones¹, Agessandro Abrahao^3,4, Clement Hamani^2,3, Suneil K. Kalia^5,6, Lorraine V. Kalia^5,7, Nir Lipsman^2,3, and Kullervo Hynynen^1,8,9
1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ³Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada, ⁴Department of Medicine, University of Toronto, Toronto, ON, Canada, ⁵Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁶Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada, ⁷Division of Neurology, Toronto Western Hospital, Toronto, ON, Canada, ⁸Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁹Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada

The phase I clinical trial demonstrated the successful application of microbubble-assisted MR-guided Focused Ultrasound for blood-brain barrier (BBB) opening in the putamen to facilitate biweekly therapeutic drug delivery in patients with Parkinson's disease.