Traditional Poster Session - Neuro
Neuro
Exhibition Halls D/E
Tuesday, 06 June 2023 13:30 - 14:30
Differential lesion volume progression following MR-guided focused ultrasound thalamotomy for Essential Tremor
Conrad P Rockel1,2, Sarah Scott3, Erin L Mazerolle4, Samuel Pichardo1,2, Davide Martino1,2, Tejas Sankar5, Zelma Kiss1,2,6, and Bruce Pike1,2
1Radiology and Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 2Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 3University of Calgary, Calgary, AB, Canada, 4Dept of Psychology, St Francis Xavier University, Antigonish, NS, Canada, 5Dept of Surgery, University of Alberta, Edmonton, AB, Canada, 6Dept of Surgery, University of Calgary, Calgary, AB, Canada
MRgFUS lesions in some Essential Tremor patients re-enlarge with later MRI follow-up, however no significant relationships in corresponding or future measures of tremor were observed between patients grouped by NonEnlarging vs Enlarging lesions.
Figure 1: Examples of NonEnlarging (top) and Enlarging (bottom) lesions as visualized by T1-weighted MRI. The orange circles illustrate the lesion location in the VIM within the thalamus, while yellow rectangles indicate the 3M-1Yr lesion volume changes by which the NonEnlarger and Enlarger groups were classified.
Figure 3: Clinical measures between groups. (A) Baseline (PRE) CRST subscore for treated 'Hand with Writing'. The NonEnlarger group had significantly more severe hand tremor than Enlarger group prior to the MRgFUS thalamotomy (p=0.038). (B) Overall CRST score. The NonEnlarger group showed significantly greater overall tremor 3 months following MRgFUS thalamotomy in comparison to the Enlarger group (p=0.024).