3721

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Digital Poster Session - Stretch, Rotate & Twist: New RF Coil Designs I

Physics & Engineering Exhibition Halls D/E

Wednesday, 07 June 2023 08:15 - 09:15

A tailored coil for sensitive detection of MRI signals in modulating the rat’s blood-brain barrier by focused ultrasound and microbubbles at 7T

Sheng-Kai Wu^1,2, Alessandro De Maio^1,2, Hsin-Ju Lee^1,2, Kullervo Hynynen^1,2, Meaghan O'Reilly^1,2, and Fa-Hsuan Lin^1,2
¹Sunnybrook Research Institute, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada

A 7T receiver coil for rat imaging was built for focused ultrasound experiments. The tailored geometry allows for a 30% SNR increase in a study modulating the blood-brain barrier with microbubbles.

Figure 1. Left: circular flat and curved coils. Middle: illustration of the placement of a circular curved coil for rat brain imaging. Right: S11 plots for circular flat and curved coils in loaded and unloaded conditions.

Figure 3: Left: T1-weighted coronal slice images using circular flat (top) and curved (bottom) coils. Blue arrows indicate the locations of FUS targets for BBB opening. Right: SNR profiles at the horizontal lines in slice 1 images.