Oral Session - Advances in RF Coil Arrays
Physics & Engineering
718B
Wednesday, 07 June 2023 15:45 - 17:45
A modular sparse hemispherical transmit/receive phased array for microbubble-mediated MR-guided focused ultrasound brain therapy
Ryan M Jones1, Dallan McMahon1, Dallas Leavitt1, Rohan Ramdoyal1, Kang U Lee1, Wai M Kan1, Steven D Yang1, Yi-Shiuan Chen1, Chris Adams1, and Kullervo Hynynen1,2
1Sunnybrook Research Institute, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada
A modular sparse hemispherical transmit/receive phased array brain system was developed and evaluated via MR-guided focused ultrasound treatments in rabbits. 3D microbubble imaging predicted MRI-inferred tissue damage volume distributions resulting from high target level sonications.
Fig.4: (Left) Post-treatment MRI scans (axial and coronal planes) from three different sequence types (T2*w, CE-T1w, and T2w) of the rabbit associated with the data presented in Fig.2 and Fig.3. (Right) Axial H&E stained tissue section corresponding to the axial MRI plane.
Fig.5: (Left) Linear regression between the segmented T2*w MRI hypointense volume and the normalized sonication-aggregate PCI intensity. (Right) Linear regression between the H&E segmented RBC area and the T2*w MRI hypointense volume. The lines of best fit and coefficient of determination (R2) values are listed as insets, and the shaded regions represent the 95% confidence bands.