Digital Poster Session - Epilepsy
Neuro
Exhibition Halls D/E
Thursday, 08 June 2023 14:45 - 15:45
Focused Ultrasound Neuromodulation combined with rs-fMRI and EEG as a preclinical tool to investigate and intervene Drug-Induced Epilepsy
Yi-Jing Juan1, Xiao Zhen1, Po‑Chun Chu2, You-Yin Chen3, Hao-Li Liu2, and Jyh-Horng Chen2
1Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei City, Taiwan, 2Department of Electrical Engineering, National Taiwan University, Taipei City, Taiwan, 3Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan
We showed that rs-fMRI monitoring and neural recording in the
same epilepsy animal model have been successfully integrated to evaluate the
drug-induced epileptic signal after PTZ injection. FUS
induced neuromodulation induced region-to-region brain functional connectivity
change.
Figure 3. longitudinal BOLD changes in (A)
normal animal, (B) animal with PTZ injection, and (C) animal with FUS
pulsations.
Figure 2. Comparison of brain wave patterns
between before and after FUS pulsations. (A) Animal with PTZ injection; (B)
animal with PTZ injection but was interfered by FUS pulsations [4]