Tissue Oxygenation: MRI Measurement & Clinical Implications
Weekend Course
ORGANIZERS: Emmanuel Barbier, Christian Federau, Daniel Moses, Dan Wu
Saturday, 03 June 2023
715A/B
13:00 -
17:00
Moderators: Hongyu An & Christine Preibisch
Skill Level: Intermediate
Session Number: WE-10
CME Credit
Session Number: WE-10
Overview
Oxygenation is fundamental to tissue physiology, and its measurement allows insight into normal and pathological states. This session investigates MRI techniques to measure tissue oxygenation and how these are applied in various organs including the brain, kidneys, heart, and placenta. Tumor hypoxia, its measurement and implications, will also be discussed.
Target Audience
Scientists, trainees, and medical doctors with an interest in advanced medical imaging techniques.
Educational Objectives
As a result of attending this course, participants should be able to:
- Explain the technical aspects of oxygen measurement using MRI;
- Identify motivations and challenges of oxygen measurement using MRI in specific tissues: brain, heart, placenta, and kidney; and
- Recognize the role of tumor hypoxia in cancer therapy and how to measure it using MRI.
13:00 | | Technical Aspects of MRI Oxygenation Measurement Thoralf Niendorf |
13:35 | | Assessing tumor oxygenation as a predictive imaging biomarker Ralph Mason Keywords: Cross-organ: Cancer, Cross-organ: Oxygenation, Contrast mechanisms: Relaxometry Hypoxia
is associated with tumor growth and development, and strongly influences some treatment
response. Various MRI techniques have been developed to assess tumor hypoxia
and dynamic response to interventions non-invasively. 19F, 1H
or ESR provide quantitative estimates of pO 2 revealing intra tumoral
heterogeneity and differential response to interventions, but require exogenous
reporter agents. Recently, oxygen-sensitive approaches based on direct
interrogation of tissue water (R 2* and R 1) have been demonstrated
in both pre-clinical studies and translational trials in humans, as potential
predictive imaging biomarkers. The review will consider state of the art and
future opportunities for development and applications. |
14:10 | | MRI of Cerebral Oxygenation: a quest to quantify the BOLD effect Thomas Christen Keywords: Neuro: Brain, Image acquisition: Quantification, Image acquisition: MR Fingerprinting In this presentation, we will follow a line of research that aims to estimate
brain oxygen extraction fraction by quantifying the famous Blood Oxygen Level
Dependent (BOLD) effect. We will see how the models and data acquisitions patterns
have been refined over the years, and how these “quantitative BOLD” methods
have been eventually fused with other MR approaches such as quantitative susceptibility mapping (QSM) or MR fingerprinting (MRF). Clinical and preclinical results will be presented in
healthy brains as well as in pathologies such as stroke or neurodegenerative
diseases. |
14:45 | | Break & Meet the Teachers |
15:15 | | MRI of Placental Oxygenation Esra Abaci Turk Keywords: Cross-organ: Oxygenation The placenta is an important organ that serves as a critical interface between a mother and her fetus. Deterioration in placental function throughout pregnancy is a leading cause of perinatal morbidity and mortality. Monitoring placental function throughout pregnancy is therefore a critical component of antenatal care, but few tools currently exist for direct assessment of placental function. MRI provides a tremendous potential for monitoring placental function. Development of quantitative MRI measures of placental oxygen delivery and transport between the mother and the fetus would increase our ability to detect placental insufficiency and could motivate and evaluate potential therapeutic interventions. |
15:50 | | MRI of Renal Oxygen Availability Pottumarthi Prasad Keywords: Body: Kidney, Contrast mechanisms: fMRI, Cross-organ: Oxygenation Unlike most organs, in the kidneys, oxygen consumption
changes with blood flow and increase in blood flow doesn't necessary lead to
increased oxygen delivery. Further,
there is a regional variation in blood and oxygen supply within the kidneys
necessitating imaging based approach. BOLD MRI is the only non-invasive method to-date
to evaluate renal oxygen availability. It
is most useful for detecting acute changes following pharmacologic
maneuvers. Limitations in conventional ROI analysis have
been identified, creating an interest in alternative methods, including whole
kidney analysis such as twelve layer concentric objects (TLCO). |
16:25 | | MRI of Cardiac Oxygenation Lian-Ming Wu |