Quantifying Spins from Head to Toe
Weekend Course
ORGANIZERS: Diego Hernando, Dan Ma, Khin Tha
Saturday, 03 June 2023
716A/B
08:00 -
11:30
Moderators: Dimitrios Karampinos & Rita Nunes
Skill Level: Basic to Intermediate
Session Number: WE-04
CME Credit
Session Number: WE-04
Overview
MRI has been shifted from being completely qualitative to providing quantifiable parameters. Several quantitative parameters have been developed so far, some showing success in research and clinical implementation whilst a few other parameters facing challenges. This education session aims to discuss the value of quantitative MR in bench and clinic, opportunities and challenges posed, and the steps required for widespread dissemination.
Target Audience
Scientists interested in quantitative imaging using MRI.
Educational Objectives
As a result of attending this course, participants should be able to:
- Discuss the value of quantitative MR in the clinic and in clinical research;
- Recognize the major challenges and opportunities for quantitative MR research;
- Describe several major areas for quantitative MR, and distinguish the different development status, opportunities, and challenges in different body regions; and
- Describe the steps required for widespread dissemination of quantitative MR methods.
08:00 | | Clinical Needs & Challenges for Neuro & Body Imaging Won-Jin Moon Keywords: Image acquisition: Quantification, Image acquisition: Sequences, Image acquisition: Multiparametric This lecture highlights the clinical needs and challenges of neuro and body MRI, with a focus on Alzheimer's, Parkinson's, epilepsy, cancer, and liver disease. Although MR imaging is a powerful tool, standard techniques may not provide the necessary information for accurate diagnosis and treatment monitoring. Advanced MRI and quantitative approaches offer promising results but have yet to fully penetrate clinical practice due to their limitations. The lecture emphasizes the need for interdisciplinary collaboration to advance the field and meet clinical demands. The potential of emerging technologies such as AI-driven image reconstruction and quantitative MRI is discussed as future directions. |
08:30 | | Diffusion Daniel Ennis Keywords: Contrast mechanisms: Diffusion Diffusion weighted MRI (DWI) and diffusion-tensor MRI (DTI) are MRI techniques that enable measuring the self-diffusion of water molecules in soft tissues. DWI and DTI methods enable quantitative estimates of the apparent diffusion coefficient (ADC) or mean diffusivity (MD), fractional anisotropy (FA), fastest direction of diffusion (eigenvectors and tracts), and more. DWI and DTI measures are uniquely sensitive to tissue orientation and organization and provide insight to tissue changes that accord with edema, anisotropy, cellularity, and more. DWI and DTI are powerful research and diagnostic clinical tools with applications in the brain, body (abdominal), chest, muscles, prostate, breasts, and beyond. |
09:00 | | Metabolites by MRS/MRSI Esin Ozturk-Isik Keywords: Contrast mechanisms: Spectroscopy Magnetic resonance spectroscopic imaging (MRS/I) provides metabolic markers that could be employed for improved patient management. This talk will summarize the challenges of MRS/I, recent advances for a more standardized approach, machine learning studies for improved MRS/I, and the importance of quantitative metabolic markers of the brain and other body parts in the clinics. |
09:30 | | Break & Meet the Teachers |
10:00 | | Electromagnetic Tissue Properties Sina Straub Keywords: Contrast mechanisms: Electromagnetic tissue properties It will be explained on which
tissue properties magnetic susceptibility, electric permittivity and electric
conductivity depend, what data needs to be acquired to map these properties,
influence these properties depend on field strength.
Learn that:
- QSM can be
used to quantify tissue magnetic susceptibility and visualized iron rich
structures
Magnetic
susceptibility depends on tissue (micro)structure and geometry
- Water/fat chemical
shift needs to be considered for body QSM
- Conductivity
(σ) and permittivity (ε) depend on frequency, temperature
- Associated
with ion concentrations and mobility, tissue type and density, pathology
- Can be
used for local SAR estimation and planning of electromagnetic related therapies
|
10:30 | | Mechanical Tissue Properties Meng Yin Keywords: Contrast mechanisms: Elastography Many
disease processes cause marked changes in tissue mechanical properties.
Mechanical properties are therefore promising biomarkers for monitoring and
characterizing various pathophysiologic conditions of soft tissues. MR-based
elastography is a phase-contrast technique for estimating multiple mechanical
properties and boundary conditions by imaging propagating shear waves generated
from a standardized extrinsic vibrating source. In practice, the innovative
stiffness biomarker is beginning to see widespread clinical use for assessing
hepatic fibrosis as an alternative to biopsy. There is significant potential to
further develop elastography techniques to implement three-dimensional
multiparametric methods that have promise for distinguishing varying pathophysiologic
states of many other organs. |
11:00 | | Promoting Standardization and Dissemination of Quantitative MRI Technology Richard Ehman Keywords: Image acquisition: Quantification, Transferable skills: Commercialisation, Transferable skills: Intellectual Property This presentation focuses on strategies for promoting
standardization and dissemination of quantitative MRI technology, spanning the pathway
from invention to eventual adoption in patient care. The presentation draws on lessons that were
learned in the development and dissemination of MR elastography, which is now a
standard of clinical practice, deployed on thousands of MRI systems around the
world. This presentation reviews
strategies for addressing hurdles and opportunities, technical and regulatory
challenges, and approaches for obtaining clinical buy-in for new quantitative MRI-based
techniques. |