Computer Number: 145

C. Ni, X. Hou, K. Hashemizadeh, S-E Kim, Q. Wen, C. Yuan, X. Ma
University of Utah, Salt Lake City, United States

Impact:

Our diffusion-prepared 3D black-blood cine MRI visualizes artery and CSF pulsation simultaneously, reduces scan time, and circumvents image registration. It allows for comprehensive evaluation of vascular function and CSF dynamics, potentially facilitating the early detection and monitoring of cerebrovascular diseases.

Computer Number: 146

E. Jeong, Y. Choi
Asan Medical Center, Seoul, Korea, Republic of

Impact: Our findings demonstrate that 3D-CE-T1WI significantly improves the accuracy of CP segmentation. This multimodal approach would facilitate more reliable volumetric analysis in both research and clinical settings.

Computer Number: 147

T. Vikner, L. Rivera-Rivera, Z. Yardim, B. Jolicoeur, K. Johnson
University of Wisconsin, Madison, United States

Impact: The current approach shows that 4D flow imaging of very slow CSF motion is feasible using high-performance head-only systems. The proposed method and our preliminary data could benefit our current understanding of human blood-CSF flow relationships and neurofluid flow dynamics. 

Computer Number: 148

C. Doctor, L. Rivera-Rivera, L. Eisenmenger, S. Johnson, K. Johnson
University of Wisconsin, Madison, United States

Impact: DENSE scans with and without induced motion were acquired, to evaluate and correct the effects of patient bulk motion. Our motion correction methods were effective in correcting for both rotational and translational bulk motion and demonstrated repeatability in test-retest analysis.

Computer Number: 149

M. van der Thiel, E. van Heese, B. van den Heuvel, V. Molina, M. Jaramillo, J. Jansen, J. Bernal
Maastricht University Medical Center, Maastricht, Netherlands

Impact: The efforts of the PVS repository team will establish an open-source platform for software code related to PVS quantification, minimizing duplicate development, enhancing reproducibility, and providing a benchmark for future development and comparison of segmentation methods.

Computer Number: 150

C-H Liao, Y-Y Cheng, C-W Chen, C-H Hsieh, S-L Peng, H-C Chang, S-C Lin, Y- Lee, C-C Lin, C-W Lin, Y-J Liu
Feng Chia University, Taichung, Taiwan

Impact: Given that DWI can be utilized to assess the circulatory condition of the parasagittal dura, our study investigates the influence of CSF on the diffusion of the parasagittal dura using both FLAIR-DWI and conventional DWI across low and high b-values.

Computer Number: 151

D. Chen, F. Wang, J. Polimeni, Z. Dong, L. Lewis
Massachusetts Institute of Technology, Cambridge, United States

Impact: Using a novel technique obtaining simultaneous CSF flow and BOLD signals, we observed significant CSF flow changes in subarachnoid space and ventricles during spontaneous BOLD fluctuations, establishing the role of low-frequency hemodynamics in driving whole-brain directional CSF flow.

Computer Number: 152

Y. Kobayashi, K. Murayama, S. Yatsushiro, K. Watanabe, K. Kuroda
Tokai University, Kanagawa, Japan

Impact: The results implies that the QSI-based quantitative visualization of neurofluid velocity is feasible even under pulsatile tissue motion occurring in the brain. Such quantitative technique will make one step further to elucidate the mechanism of neurowaste clearance system.

Computer Number: 153

K. Mortensen, T. Lilius, M. Rosenholm, B. Sigurðsson, D. Kelley, M. Nedergaard
Hvidovre Hospital, Hvidovre, Denmark

Impact: Our novel CSF inflow measurement method underscores a probable connection between brain waste clearance and cerebrospinal fluid inflow. It provides a quantitative platform for future biomarkers in both preclinical and clinical investigations of brain waste clearance and CSF circulation.

Computer Number: 154

E. Karasan, M. Lustig
UC Berkeley, Berkeley, United States

Impact: This study demonstrates the potential of DENSE and DiSpect MRI to capture slow CSF flow dynamics, offering a valuable tool for detailed studies of CSF clearance mechanisms. This approach could enhance understanding of neurological conditions linked to brain clearance.

Computer Number: 155

K. Murayama, Y. Kobayashi, K. Watanabe, S. Yatsushiro, K. Kuroda
Tokai university, Kanagawa, Japan

Impact: The regular movements of water molecules of a 1-10 μm/s were observed in the corpus callosum and fimbria in the brain parenchyma, indicating that it may be associated with cerebrospinal fluid, which is thought to move along white matter tracts.

Computer Number: 156

T. Rafiq, T. Choi, H. Lee, R. E. Yoo, S. H. Choi, J. Park, J. Park
Sungkyunkwan University, Suwon, Korea, Republic of

Impact: This study highlights enhanced CSF dynamics over the whole brain in rats with the LIFU-induced stimulation, potentially facilitating waste clearance in glymphatic system.

Computer Number: 157

Y. Wu, F. Xu, D. Zhu, A. Li, K. Wang, Q. Qin, J. Xu
Johns Hopkins University, Baltimore, United States

Impact: This study underscores the potential of VSSL MRI as a non-invasive tool for investigating CSF dynamics in both PVSAS of arteries and ventricles, offering significant insights into CSF circulation in both healthy and pathological conditions.

Computer Number: 158

D. De, N. Bateman, A. Nazeri, S. Pan, J. Quirk, J. Strahle
Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, United States

Impact: Deuterium displacement MRI enables precise, non-invasive mapping of cerebrospinal fluid (CSF) production, advancing neurofluid disorder research. It enhances understanding of CSF dynamics and neurotoxin clearance, especially in brain regions associated with neurodegenerative diseases.

Computer Number: 159

S-H Oh, K. Sakaie, G. Lee, S. Jones, M. Lowe
The Cleveland Clinic Foundation, Cleveland, United States

Impact: We present a new approach to image the glymphatic system. With further development, early detection and evaluation of intervention strategies for a broad range of neurodegenerative diseases may become possible.

Computer Number: 160

M. Debiasi, M. J. van Osch, Y. Dong, L. Hirschler
C.J. Gorter MRI Center, Radiology, Leiden UMC, Leiden, Netherlands

Impact: The improvement in acquisition speed makes CSF-STREAM more suitable to fit into scanning protocols including patients. Together with the improvement in the reconstruction, we made CSF-STREAM a powerful, contrast-free sequence to study glymphatics in humans in-vivo.